Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Martine I. Abboud"'
Autor:
Raphael Reinbold, Ingvild C. Hvinden, Patrick Rabe, Ryan A. Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J. Clifton, Fraser A. Armstrong, James S. O. McCullagh, Jo Redmond, Chiara Bardella, Martine I. Abboud, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The development of IDH variant inhibitors is a breakthrough as it is the first time metabolism has been successfully targeted by small molecule drugs in cancer. Here the authors report studies on resistance to the pioneer drug ivosidenib leading to i
Externí odkaz:
https://doaj.org/article/e3e859d6d730417f8d6ec356de38fe1b
Autor:
Rasheduzzaman Chowdhury, Martine I. Abboud, James Wiley, Anthony Tumber, Suzana Markolovic, Christopher J. Schofield
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The JmjC family of 2-oxoglutarate dependent oxygenases catalyse a range of hydroxylation and demethylation reactions in humans and other animals. Jumonji domain-containing 7 (JMJD7) is a JmjC (3S)-lysyl-hydroxylase that catalyses the modific
Externí odkaz:
https://doaj.org/article/77195d9f25814b63ac7af57680c41a8a
Autor:
Shuang Liu, Martine I. Abboud, Tobias John, Victor Mikhailov, Ingvild Hvinden, John Walsby-Tickle, Xiao Liu, Ilaria Pettinati, Tom Cadoux-Hudson, James S. O. McCullagh, Christopher J. Schofield
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Liu et al investigate the effects of divalent metal ions on catalysis and inhibition of the enzyme isocitrate dehydrogenase (IDH) and its cancer-linked variant R132H. They further identify the substrates for IDH as complexes with Mg2+ and show that a
Externí odkaz:
https://doaj.org/article/87f044b46ee747dba26b0e27f7cc54e6
Autor:
Rasheduzzaman Chowdhury, Martine I. Abboud, Tom E. McAllister, Biswadip Banerji, Bhaskar Bhushan, John L. Sorensen, Akane Kawamura, Christopher J. Schofield
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Abstract Crystallization is the bottleneck in macromolecular crystallography; even when a protein crystallises, crystal packing often influences ligand-binding and protein–protein interaction interfaces, which are the key points of interest for fun
Externí odkaz:
https://doaj.org/article/7ffb0667b88f4bb4a12b5e6a229217a5
Autor:
Rasheduzzaman Chowdhury, Ivanhoe K. H. Leung, Ya-Min Tian, Martine I. Abboud, Wei Ge, Carmen Domene, François-Xavier Cantrelle, Isabelle Landrieu, Adam P. Hardy, Christopher W. Pugh, Peter J. Ratcliffe, Timothy D. W. Claridge, Christopher J. Schofield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
The response to hypoxia involves multiple genes regulated by the hypoxia inducible transcription factors (HIFs), whose stability is regulated by prolyl hydroxylation. Here the authors provide a molecular basis for the substrate selectivity of the HIF
Externí odkaz:
https://doaj.org/article/bcbb0397431d45b6a10192b43d152868
Autor:
Haotian Liu, Yong Xie, Xia Wang, Martine I. Abboud, Chao Ma, Wei Ge, Christopher J. Schofield
Publikováno v:
Alzheimer's & Dementia. 18:2637-2668
Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheimer's disease (AD). 2-Oxoglutarate and ferrous iron-dependent oxygenases (2OGDD) play a key role in the regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::846d910aab0d32884d9659ddc0ab394f
https://doi.org/10.1002/alz.12733
https://doi.org/10.1002/alz.12733
Autor:
Matthew E Cockman, Kerstin Lippl, Ya-Min Tian, Hamish B Pegg, William D Figg Jnr, Martine I Abboud, Raphael Heilig, Roman Fischer, Johanna Myllyharju, Christopher J Schofield, Peter J Ratcliffe
Publikováno v:
eLife, Vol 8 (2019)
Human and other animal cells deploy three closely related dioxygenases (PHD 1, 2 and 3) to signal oxygen levels by catalysing oxygen regulated prolyl hydroxylation of the transcription factor HIF. The discovery of the HIF prolyl-hydroxylase (PHD) enz
Externí odkaz:
https://doaj.org/article/70d88ea4f82c4443ab41453328102032
Autor:
Martine I. Abboud, Ryan A. Herold, Raphael Reinbold, Clare F. Megarity, Christopher J. Schofield, Fraser A. Armstrong
Publikováno v:
The Journal of Physical Chemistry Letters
Herold, R A, Reinbold, R, Megarity, C F, Abboud, M I, Schofield, C J & Armstrong, F A 2021, ' Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant ', Journal of Physical Chemistry Letters, vol. 12, pp. 6095-6101 . https://doi.org/10.1021/acs.jpclett.1c01517
Herold, R A, Reinbold, R, Megarity, C F, Abboud, M I, Schofield, C J & Armstrong, F A 2021, ' Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant ', Journal of Physical Chemistry Letters, vol. 12, pp. 6095-6101 . https://doi.org/10.1021/acs.jpclett.1c01517
Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H) are rendered electroactive through coconfinement with a rapid NADP(H) recycling enzyme (ferredoxin-NADP+ reductase) in nanopores formed within an indium tin oxide el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33cc3289dfc656e1f183b5fa39b0b1e
https://doi.org/10.1021/acs.jpclett.1c01517
https://doi.org/10.1021/acs.jpclett.1c01517
Autor:
MuiPhin Chong, Christopher J. Schofield, Anthony Tumber, LeeRoy Toh, Martine I. Abboud, YanYing Chan, Mun Chiang Chan, Kar Kheng Yeoh
Publikováno v:
Medicinal Chemistry Research. 30:977-986
There is current interest in developing human hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) inhibitors for the treatment of anemia and other hypoxia-related diseases. We describe the synthesis of 3-carbamoylpropanoic acid derivatives
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4e9aa43b1ac06eee26c2cad2f423597
https://doi.org/10.1007/s00044-020-02681-7
https://doi.org/10.1007/s00044-020-02681-7
Autor:
James Wickens, Adam P. Hardy, Anthony Tumber, Martine I. Abboud, Michael A. McDonough, Christopher T. Lohans, Rasheduzzaman Chowdhury, Christopher M. West, Kerstin Lippl, Christopher J. Schofield, Elisabete Pires, Tongri Liu
Publikováno v:
The Journal of Biological Chemistry
In animals, the response to chronic hypoxia is mediated by prolyl hydroxylases (PHDs) that regulate the levels of hypoxia-inducible transcription factor α (HIFα). PHD homologues exist in other types of eukaryotes and prokaryotes where they act on n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58832b590e90128d122e6f594a718649
https://doi.org/10.1074/jbc.ra120.013998
https://doi.org/10.1074/jbc.ra120.013998