Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Martine Gaillard-Kelly"'
Publikováno v:
British Journal of Cancer
Background: The type I insulin-like growth factor receptor (IGF1R) is a transmembrane tyrosine kinase involved in cancer proliferation, survival, and metastasis. Methods: In this study, we used two different fluorescent technologies (small-molecule f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd55e860f4141099c2ec6ebebe00c30
http://europepmc.org/articles/PMC2713715
http://europepmc.org/articles/PMC2713715
Publikováno v:
Clinical Cancer Research. 15:2840-2849
Purpose: The aim of this study was to determine the optimal sequence of combining anti-type I insulin-like growth factor receptor (IGF1R) antibodies with chemotherapeutic drugs in cancer cells in vitro and in vivo. Experimental Design: MCF-7 and LCC6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7678ace28af1dc75b0ae9160f42b0b3f
https://doi.org/10.1158/1078-0432.ccr-08-1401
https://doi.org/10.1158/1078-0432.ccr-08-1401
Autor:
Natalie A, Sims, Philippe, Clément-Lacroix, Dominique, Minet, Caroline, Fraslon-Vanhulle, Martine, Gaillard-Kelly, Michèle, Resche-Rigon, Roland, Baron
Publikováno v:
Journal of Clinical Investigation. 111:1319-1327
Although the role of estradiol in maintaining bone mass is well established, the relative contributions of the estradiol receptors ERalpha and ERbeta and of the androgen receptor (AR) remain controversial. To determine the role of ERalpha-mediated, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93924ec859ee2c22655ae1cd92542633
https://doi.org/10.1172/jci200317246
https://doi.org/10.1172/jci200317246
Autor:
Francesca Da Ponte, Yasmina Bouali, John J. Kopchick, Martine Gaillard-Kelly, Karen T. Coschigano, Nadine Binart, Natalie A. Sims, Philippe Clément-Lacroix, Vincent Goffin, Richard Moriggl, Roland Baron, Paul A. Kelly
Publikováno v:
Journal of Clinical Investigation. 106:1095-1103
Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by the GH receptor (GHR) and/or IGF-I signaling. The actions of GH are transduced by the Jak/Stat signaling pathway via Stat5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748e5322ac0bfde0fcab12b81f4a7747
https://doi.org/10.1172/jci10753
https://doi.org/10.1172/jci10753
Autor:
Paul A. Kelly, Nadine Binart, Michael Amling, Liên Lepescheux, Vincent Goffin, Philippe Clément-Lacroix, Roland Baron, Diane Damotte, Martine Gaillard-Kelly, Brigitte Bouchard, Christopher J. Ormandy, Patrick Ammann
Publikováno v:
Endocrinology. 140:96-105
Bone development is a multistep process that includes patterning of skeletal elements, commitment of hematopoietic and/or mesenchymental cells to chondrogenic and osteogenic lineages, and further differentiation into three specialized cell types: cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76d845abb819367f162e3303f24e550a
https://doi.org/10.1210/endo.140.1.6436
https://doi.org/10.1210/endo.140.1.6436
Autor:
D. Gofflo, Evelyne Cerede, T. Battmann, G. Teutsch, Martine Gaillard-Kelly, A. Bonfils, Daniel Philibert, Francoise Bouchoux, Francois Goubet
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 48:111-119
New N-substituted arylthiohydantoin antiandrogens were synthesized. These compounds presented exceptionally high relative binding affinities (RBAs) for the rat androgen receptor (AR): up to 3 times that of testosterone (T) and 100 times the RBAs of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b010fd3f3b732626498cf6d6f8415a3
https://doi.org/10.1016/0960-0760(94)90257-7
https://doi.org/10.1016/0960-0760(94)90257-7
Publikováno v:
Oncogene
The type I insulin-like growth factor receptor (IGF1R) regulates multiple aspects of malignancy and is the target of several drugs currently in clinical trials. Although the function of IGF1R in proliferation and survival is well studied, the regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b419145805cda7f3cbccebd055ec7a
https://pubmed.ncbi.nlm.nih.gov/19838209
https://pubmed.ncbi.nlm.nih.gov/19838209
Publikováno v:
Breast cancer research and treatment. 114(2)
The type I insulin-like growth factor (IGF) receptor (IGF1R) is a transmembrane tyrosine kinase involved in breast cancer proliferation, survival, and metastasis. Several monoclonal antibodies directed against the receptor are in clinical trials. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2259bb030a1cdb0ea285a3b54128b556
https://pubmed.ncbi.nlm.nih.gov/18418709
https://pubmed.ncbi.nlm.nih.gov/18418709
Autor:
Dominique Minet, Roland Baron, S Dupont, A Krust, P Clement-Lacroix, Martine Gaillard-Kelly, Michèle Resche-Rigon, Natalie A. Sims
Publikováno v:
Bone. 30(1)
To determine the contributions of estrogen receptor (ER)alpha and ERbeta in bone growth and remodeling in male and female mice, we generated and analyzed full knockouts for each receptor, and a double ER knockout. Although suppression of the ligand t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b076e3cc871b55a55aed37321ad29a4c
https://pubmed.ncbi.nlm.nih.gov/11792560
https://pubmed.ncbi.nlm.nih.gov/11792560
Autor:
G. Teutsch, Francoise Bouchoux, Martine Gaillard-Kelly, Francois Goubet, Daniel Philibert, C. Branche, Evelyne Cerede, T. Battmann
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 64(1-2)
The pharmacological profile of RU 58642, a new non-steroidal antiandrogen was investigated both in vitro and in vivo. In vitro, the compound displays a strong and specific affinity for androgen receptor. In vivo, its antiandrogenic activity was evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723916b80a51217c6b671092d6e11182
https://pubmed.ncbi.nlm.nih.gov/9569015
https://pubmed.ncbi.nlm.nih.gov/9569015