Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Martine Dehlinger Kremer"'
Autor:
Christina Bucci-Rechtweg, Angeliki Siapkara, Kristina An Haack Bonnet, Solange Corriol Rohou, Elin Haf Davies, Martine Dehlinger Kremer, Margaret Gamalo, Carmen Moreno, Robert M Nelson, Rhian Thomas Turner
Publikováno v:
Clinical Trials. 20:13-21
Background: Historically, pediatric medicines are developed after adult trials are completed, even when identical drug targets and disease similarities exist across the populations. This has resulted in significant delays in the authorization of medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269c4fe54475265e57b18d1fec0eb398
https://doi.org/10.1177/17407745221132302
https://doi.org/10.1177/17407745221132302
Autor:
Viviana Giannuzzi, Pirkko Lepola, Jean Conway, David Neubauer, Jo Dewhurst, Diane Hoffman, Geraldine B. Boylan, Martine Dehlinger-Kremer, Heidi Glosli, Harris Dalrymple, Maxine Kindred
Objective Clinical trial sponsors spend considerable resources preparing informed consent (IC) and assent documentation for multinational paediatric clinical trial applications in Europe due to the limited and dispersed patient populations, the varia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e17027ee60ca38313e745d47801659a
http://hdl.handle.net/10138/353130
http://hdl.handle.net/10138/353130
Autor:
Thomas, Severin, Solange, Corriol-Rohou, Christina, Bucci-Rechtweg, Kristina, An Haack, Sabine, Fuerst-Recktenwald, Pirkko, Lepola, Ensio, Norjavaara, Martine, Dehlinger-Kremer, Sebastian, Haertter, S Y Amy, Cheung
Publikováno v:
Ther Innov Regul Sci
Therapeutic Innovation & Regulatory Science
Therapeutic Innovation & Regulatory Science
Correction; Early Access: DOI: 10.1007/s43441-020-00152-0 Early Access: APR 2020 Background Pediatric regulations enacted in both Europe and the USA have disrupted the pharmaceutical industry, challenging business and drug development processes, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6fcac4e4891954d49aa2a4265d9e3d
https://pubmed.ncbi.nlm.nih.gov/32865808
https://pubmed.ncbi.nlm.nih.gov/32865808
Autor:
Sabine Fuerst-Recktenwald, Ensio Norjavaara, Kristina An Haack, Pirkko Lepola, Solange Corriol-Rohou, S.Y. Amy Cheung, Thomas Severin, Christina Bucci-Rechtweg, Sebastian Haertter, Martine Dehlinger-Kremer
Publikováno v:
Therapeutic Innovation & Regulatory Science. 54:1085-1085
The article How is the Pharmaceutical Industry Structured to Optimize Pediatric Drug Development? Existing Pediatric Structure Models and Proposed Recommendations for Structural Enhancement, written by Thomas Severin et al. was originally published e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4fb7745297d96dfd3b45b62a4f16688
https://doi.org/10.1007/s43441-020-00152-0
https://doi.org/10.1007/s43441-020-00152-0
Publikováno v:
Drug Information Journal. 45:89-105
This article summarizes the conclusions and discussion from a workshop in Brussels, jointly organized by the European Forum for Good Clinical Practice and the European CRO Federation, looking at how pediatric and geriatric clinical research might lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39331d84c97cb5d19c8ce8691f91392e
https://doi.org/10.1177/009286151104500110
https://doi.org/10.1177/009286151104500110
Publikováno v:
The Journal of Membrane Biology. 119:85-100
Previous studies have shown the existence of functionally distinguishable inositol 1,4,5-trisphosphate- (IP3) sensitive and IP3-insensitive nonmitochondrial intracellular Ca2+ pools in acinar cells of the exocrine pancreas. For further characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d70b81de4d50eca46a6eeae75e2e12
https://doi.org/10.1007/bf01868543
https://doi.org/10.1007/bf01868543
Autor:
Martina Nehls-Sahabandu, Georg W. Mayr, Irene Schulz, Beate Grabowsky, Martine Dehlinger-Kremer, Rainer Schäfer
We have synthesized two photolabile arylazido-analogues of Ins(1,4,5)P3 selectively substituted at the 1-phosphate group for determination of Ins(1,4,5)P3-binding proteins. These two photoaffinity derivatives, namely N-(4-azidobenzoyl)aminoethanol-1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1098d22fbf3d9a3417ac1c2e97912f4
https://europepmc.org/articles/PMC1149781/
https://europepmc.org/articles/PMC1149781/
Publikováno v:
Nature. 346(6282)
STIMULUS–SECRETION coupling in exocrine glands involves Ca2+ release from intracellular stores1,2. In endoplasmic reticulum vesicle preparations from rat exocrine pancreas, an inositol 1,4,5-trisphosphate(InsP3)-sensitive, as well as an InsP3-insen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196f77585352968db91826cb9e1d84ca
https://pubmed.ncbi.nlm.nih.gov/1695718
https://pubmed.ncbi.nlm.nih.gov/1695718
Publikováno v:
Cell Calcium. 10:325-336
Intracellular Ca2+ pools play an important role in the adjustment of cytosolic free Ca2+ concentrations. This review summarizes the recent knowledge on receptor-mediated Ca2+ release and Ca2+ uptake mechanisms in Ca2+ stores of exocrine cells taking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55675120a1529940a84447b5f2fda95c
https://doi.org/10.1016/0143-4160(89)90058-4
https://doi.org/10.1016/0143-4160(89)90058-4