Výsledky vyhledávání - "Martine Cuillel"

A liver-targeting Cu(l) chelator relocates Cu in hepatocytes and promotes Cu excretion in a murine model of Wilson's disease

Autor: Khémary Um, Elisabeth Mintz, Anaïs Pujol, Vincent Balter, Virginie Brun, Sylvain Bohic, Marie Monestier, Peggy Charbonnier, Doris Cassio, Amélie Harel, Martine Cuillel, Isabelle Pignot-Paintrand, Christelle Gateau, Aline Lamboux, Pascale Delangle

Publikováno v: Metallomics
Metallomics, 2020, 12 (6), pp.1000-1008. ⟨10.1039/d0mt00069h⟩
Metallomics, Royal Society of Chemistry, 2020, 12 (6), pp.1000-1008. ⟨10.1039/d0mt00069h⟩

Copper chelation is the most commonly used therapeutic strategy nowadays to treat Wilson’s disease, a genetic disorder primarily inducing a pathological accumulation of Cu in the liver. The mechanism of action of Chel2, a liver-targeting Cu(i) chel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76e699880bbaa7cf000013317d203fb
https://hal.science/hal-02911050/document

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ASGPR-Mediated Uptake of Multivalent Glycoconjugates for Drug Delivery in Hepatocytes

Autor: Pascale Delangle, Marie Monestier, Elisabeth Mintz, Martine Cuillel, Colette Lebrun, Christelle Gateau, Faustine Robert, Peggy Charbonnier, Olivier Renaudet

Publikováno v: ChemBioChem
ChemBioChem, Wiley-VCH Verlag, 2016, 17 (7), pp.590-594. ⟨10.1002/cbic.201600023⟩
ChemBioChem, 2016, 17 (7), pp.590-594. ⟨10.1002/cbic.201600023⟩

International audience; Liver cells are an essential target for drug delivery in many diseases. The hepatocytes express the asialoglycoprotein receptor (ASGPR), which promotes specific uptake by means of N-acetylgalactosamine (GalNAc) recognition. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6513beec2005f7e9bb1b1ea95a3f2b0
https://doi.org/10.1002/cbic.201600023

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Modulation of hepatic copper-ATPase activity by insulin and glucagon involves protein kinase A (PKA) signaling pathway

Autor: Jennifer Lowe, Doris Cassio, Elisabeth Mintz, Adalberto Vieyra, Peggy Charbonnier, Martine Cuillel, Elaine Hilário-Souza

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 2016, 1862 (11), pp.2086-2097. ⟨10.1016/j.bbadis.2016.08.008⟩
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2016, 1862 (11), pp.2086-2097. ⟨10.1016/j.bbadis.2016.08.008⟩

International audience; Different studies have revealed copper imbalance in individuals suffering from diabetes and obesity, suggesting that regulation of glucose and/or fat metabolism could modulate cellular copper homeostasis. To test this hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ec5a8bece6b06305a6659a948758b3
https://hal.science/hal-01358732

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Hepatocyte Targeting and Intracellular Copper Chelation by a Thiol-Containing Glycocyclopeptide

Autor: Martine Cuillel, Anaïs Pujol, Doris Cassio, Peggy Charbonnier, Olivier Renaudet, Christelle Gateau, Elisabeth Mintz, Pascal Dumy, Pascale Delangle, Colette Lebrun

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2011, 133 (2), pp.286-296. ⟨10.1021/ja106206z⟩
Journal of the American Chemical Society, American Chemical Society, 2011, 133 (2), pp.286-296. ⟨10.1021/ja106206z⟩

International audience; Metal overload plays an important role in several diseases or intoxications, like in Wilson’s disease, a major genetic disorder of copper metabolism in humans. To efficiently and selectively decrease copper concentration in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e5d6fc531a54719116ccbd231449991
https://doi.org/10.1021/ja106206z

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Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions

Autor: Isabelle Michaud-Soret, Isabelle Pignot-Paintrand, Josiane Arnaud, Mireille Chevallet, Doris Cassio, Peggy Charbonnier, Martine Cuillel, Caroline Fauquant, Elisabeth Mintz

Publikováno v: Nanoscale
Nanoscale, 2014, 6 (3), pp.1707-1715. ⟨10.1039/c3nr05041f⟩
Nanoscale, Royal Society of Chemistry, 2014, 6 (3), pp.1707-1715. ⟨10.1039/c3nr05041f⟩

International audience; Copper oxide nanoparticles (CuO-NP) were studied for their toxicity and mechanism of action on hepatocytes (HepG2), in relation to Cu homeostasis disruption. Indeed, hepatocytes, in the liver, are responsible for the whole bod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ed5a54f29ddb66a0a9b51f752cb66c2
https://hal.science/hal-00936382

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Peptide Mapping and Disulfide Bond Analysis of the Cytoplasmic Region of an Intrinsic Membrane Protein by Mass Spectrometry

Autor: Yves Dupont, Martine Cuillel, Andrew A. Mundt, Eric Forest

Publikováno v: Analytical Biochemistry. 299:147-157

Intrinsic membrane proteins pose substantial obstacles to analysis by common analytical techniques due to their hydrophobic nature and solubilization requirements. This is the case for studies involving HPLC coupled to mass spectrometry. We have deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e9a211e7f7f4b902274c5ecb0d20b0
https://doi.org/10.1006/abio.2001.5416

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Purification of Heterologous Sarcoplasmic Reticulum Ca2+-ATPase Serca1a Allowing Phosphoenzyme and Ca2+-Affinity Measurements

Autor: Roger Miras, Martine Cuillel, Patrice Catty, Elisabeth Mintz, Florent Guillain

Publikováno v: Protein Expression and Purification. 22:299-306

We describe here a protocol to prepare milligrams of active and stable heterologous sarcoplasmic reticulum Ca(2+)-ATPase (Serca1a). Serca1a was tagged with 6 histidines at its C-terminal end and overexpressed using the baculovirus-Sf9 system. In a fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b31e14d2bff78e20bea0f8d0b66ab7
https://doi.org/10.1006/prep.2001.1436

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Cartographic study: Breakpoints in 1574 families carrying human reciprocal translocations

Autor: Jean Louis Gilardi, Hubert Roth, Pierre Jalbert, Olivier Cohen, Marie-Ange Mermet, Christine Cans, Jacques Demongeot, Martine Cuillel

Publikováno v: Human Genetics. 97:659-667

Reciprocal translocations (rcp) are among the most common constitutional chromosomal aberrations in man. Using a European database of 1574 families carrying autosomal rcp, a cartographic study was done on the breakpoints involved. The breakpoints are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621fbd1cac0853951c5fe64bcdd1d090
https://doi.org/10.1007/bf02281879

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Evidence for direct involvement of the sarcoplasmic reticulum Ca2+-ATPase in a passive monovalent cation (K+/Na+) exchange

Autor: Martine Cuillel, Yves Dupont, Florence de Jesus

Publikováno v: FEBS Letters. 376:167-171

A specific inhibitor of SERCA-pumps, thapsigargin (TG) was used to demonstrate the direct involvement of the SR Ca(2+)-ATPase in passive K+/Na+ exchange. The K(+)-potential variations across vesicle membranes were measured in the absence of ATP with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a076bd5dfd00e86bdf8ce14c0470dece
https://doi.org/10.1016/0014-5793(95)01267-1

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A sulfur tripod glycoconjugate that releases a high-affinity copper chelator in hepatocytes

Autor: Anne-Solène Jullien, Anaïs M. Pujol, Doris Cassio, Martine Cuillel, Colette Lebrun, Christelle Gateau, Elisabeth Mintz, Pascale Delangle

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2012, 51 (30), pp.7445-7448. ⟨10.1002/anie.201203255⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51 (30), pp.7445-7448. ⟨10.1002/anie.201203255⟩

International audience; Released in the cell: Three N-acetylgalactosamine units, which recognize the asialoglycoprotein receptor, were tethered through disulfide bonds to the three coordinating thiol functions of a sulfur tripod ligand that has a hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a9499c7435cbf398a180ddd6385bd7
https://pubmed.ncbi.nlm.nih.gov/22730309

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