RELSA—A multidimensional procedure for the comparative assessment of well-being and the quantitative determination of severity in experimental procedures

Autor: Steven R. Talbot, Birgitta Struve, Laura Wassermann, Miriam Heider, Nora Weegh, Tilo Knape, Martine C. J. Hofmann, Andreas von Knethen, Paulin Jirkof, Christine Häger, André Bleich

Publikováno v: Frontiers in Veterinary Science, Vol 9 (2022)

Good science in translational research requires good animal welfare according to the principles of 3Rs. In many countries, determining animal welfare is a mandatory legal requirement, implying a categorization of animal suffering, traditionally domin

Externí odkaz: https://doaj.org/article/a4fc9e7b330b43b6bb9893ea57bb909b

Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels—An Exploratory In Vivo Kinetic Study

Autor: Hendrik Nieraad, Natasja de Bruin, Olga Arne, Martine C. J. Hofmann, Robert Gurke, Dominik Schmidt, Marcel Ritter, Michael J. Parnham, Gerd Geisslinger

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2, p 927 (2021)

Hyperhomocysteinemia has been suggested potentially to contribute to a variety of pathologies, such as Alzheimer’s disease (AD). While the impact of hyperhomocysteinemia on AD has been investigated extensively, there are scarce data on the effect o

Externí odkaz: https://doaj.org/article/91a56078d56a43e3a7bddf02a857b5f4

Improving target assessment in biomedical research: the GOT-IT recommendations

Autor: Michael J. Parnham, Pascal Schendel, Marc Bonin-Andresen, Martine C J Hofmann, Anton Bespalov, Ulrich Dirnagl, Olga Arbach, Christoph H. Emmerich, Katja Hempel, Lorena Martinez Gamboa, Björn Gerlach

Publikováno v: Nature Reviews. Drug Discovery

Academic research plays a key role in identifying new drug targets, including understanding target biology and links between targets and disease states. To lead to new drugs, however, research must progress from purely academic exploration to the ini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda4f272f006331740c676d7e8c2797b
http://europepmc.org/articles/PMC7667479

Introduction to the EQIPD quality system

Autor: Lior Bikovski, Raafat Fares, Anton Bespalov, Claudia Kurreck, Leonardo Restivo, Paul Moser, Chantelle Ferland-Beckham, Claudia Stöger, Patricia Kabitzke, Ernesto Prado Montes de Oca, Bruce Altevogt, Valerie Gailus-Durner, Sabine M. Hölter, Piotr Popik, Martine C J Hofmann, Vootele Voikar, Lee Monk, Michael Schunn, Alexander Dityatev, Janko Samardzic, Gernot Riedel, Thomas Steckler, Natasja de Bruin, Merel Ritskes-Hoitinga, Kathleen Wuyts, Christoph H. Emmerich, Heidrun Potschka, Vincent Castagné, Christelle Froger-Colléaux, Fiona Ducrey, Anja Gilis, Björn Gerlach, Jan Vollert, Kimberley E. Wever, Sandrine Bongiovanni, Esmeralda Castaños-Vélez, Martien J H Kas, René Bernard, Malcolm R. Macleod, Isabel A Lefevre, Javier Guillén, Małgorzata Pietraszek, María Arroyo-Araujo, Ulrich Dirnagl

Publikováno v: Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-araujo, M, Bikovski, L, De Bruin, N, Castaños-vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-beckham, C, Froger-colléaux, C, Gailus-durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes De Oca, E, Restivo, L, Riedel, G, Ritskes-hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, Macleod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.63294
eLife, 10:e63294. ELIFE SCIENCES PUBLICATIONS LTD
eLife, Vol 10 (2021)
eLife 10, e63294 (2021). doi:10.7554/eLife.63294
eLife
Elife, 10
Bespalov, A, Bernard, R, Gilis, A, Gerlach, B, Guillén, J, Castagné, V, Lefevre, I A, Ducrey, F, Monk, L, Bongiovanni, S, Altevogt, B, Arroyo-Araujo, M, Bikovski, L, de Bruin, N, Castaños-Vélez, E, Dityatev, A, Emmerich, C H, Fares, R, Ferland-Beckham, C, Froger-Colléaux, C, Gailus-Durner, V, Hölter, S M, Hofmann, M C, Kabitzke, P, Kas, M J, Kurreck, C, Moser, P, Pietraszek, M, Popik, P, Potschka, H, Prado Montes de Oca, E, Restivo, L, Riedel, G, Ritskes-Hoitinga, M, Samardzic, J, Schunn, M, Stöger, C, Voikar, V, Vollert, J, Wever, K E, Wuyts, K, MacLeod, M R, Dirnagl, U & Steckler, T 2021, ' Introduction to the EQIPD quality system ', eLife, vol. 10, e63294 . https://doi.org/10.7554/eLife.63294
eLife, vol. 10, pp. e63294

While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted to date have clearly identified measures that need to be take

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aef7c0ead5b242adb59f95192215766
http://hdl.handle.net/10044/1/95909

Effects of Alzheimer-Like Pathology on Homocysteine and Homocysteic Acid Levels-an Exploratory In Vivo Kinetic Study

Autor: Olga Arne, Natasja de Bruin, Michael J. Parnham, Gerd Geisslinger, Hendrik Nieraad, Dominik Schmidt, Marcel Ritter, Robert Gurke, Martine C J Hofmann

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 927, p 927 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 2

Hyperhomocysteinemia has been suggested potentially to contribute to a variety of pathologies, such as Alzheimer&rsquo
s disease (AD). While the impact of hyperhomocysteinemia on AD has been investigated extensively, there are scarce data on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055566f33e593547082880085cc967e9
https://www.mdpi.com/1422-0067/22/2/927