Dendritic cell-mediated-immunization with xenogenic PrP and adenoviral vectors breaks tolerance and prolongs mice survival against experimental scrapie.

Autor: Martine Bruley Rosset, Antoine Sacquin, Sylvie Lecollinet, Thomas Chaigneau, Micheline Adam, François Crespeau, Marc Eloit

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4917 (2009)

In prion diseases, PrP(c), a widely expressed protein, is transformed into a pathogenic form called PrP(Sc), which is in itself infectious. Antibodies directed against PrP(c) have been shown to inhibit PrP(c) to PrP(Sc) conversion in vitro and protec

Externí odkaz: https://doaj.org/article/97835024fb9049be8538e9f5355fb1c2

Polyreactive Autoantibodies Purified from Human Intravenous Immunoglobulins Prevent the Development of Experimental Autoimmune Diseases

Autor: Youri Chanseaud, Martine Bruley-Rosset, Frederic Dhainaut, Dominique Bourel, Jacky Lirochon, Luc Mouthon

Publikováno v: Laboratory Investigation. 83:1013-1023

Intravenous immunoglobulins (IVIg) are therapeutic preparations of normal human polyclonal Ig G (IgG) that exert immunomodulatory effects in patients with autoimmune or systemic inflammatory diseases. Two different IgG subfractions were evaluated for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086ef9c31a64042813d82970725277f8
https://doi.org/10.1097/01.lab.0000077982.70800.02

Graft-Versus-Host Disease and Graft-Versus-Leukemia Effect in Mice Grafted With Peripheral Newborn Blood

Autor: Véronique de La Selle, Martine Bruley-Rosset, Eliane Gluckman

Publikováno v: Blood. 92:3968-3975

We previously used peripheral newborn blood (NBB) as a possible in vivo experimental model for cord blood (CB) transplantation and showed that B10.D2 NBB cells successfully reconstituted adult (DBA/2 × B10.D2)F1 mice without causing graft-versus-hos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445179e3a6eff9f5bc9b5d7e89472e92
https://doi.org/10.1182/blood.v92.10.3968.422k32_3968_3975

Critical role of endogenousMtv in acute lethal graft-versus-host disease

Autor: Thierry Roger, Martine Bruley-Rosset, Isabelle Miconnet, Michel Seman

Publikováno v: European Journal of Immunology. 25:364-368

Little is known about the etiology of the graft-versus-host disease (GVHD) occuring after transplantation of lymphoid cells incompatible for minor histocompatibility antigens (mHAg). Here, the potential role of host endogenous mouse mammary tumor vir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4a72faf64adcf372c0ef40c7a2a79d
https://doi.org/10.1002/eji.1830250209

MHC-Independent Genetic Factors Control the Magnitude of CD4+ T Cell Responses to Amyloid- Peptide in Mice through Regulatory T Cell-Mediated Inhibition

Autor: Maria Manuel Nunes, Pierre Aucouturier, Cécile Toly-Ndour, Gabrielle Lui, Guillaume Dorothée, Martine Bruley-Rosset

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2011, 187 (9), pp.4492-4500. ⟨10.4049/jimmunol.1003953⟩
Journal of Immunology, 2011, 187 (9), pp.4492-4500. ⟨10.4049/jimmunol.1003953⟩

Accumulation of amyloid-β peptide (Aβ) is considered the triggering factor of pathogenic lesions in Alzheimer’s disease (AD), and vaccines targeting Aβ are promising therapeutic options. However, the occurrence of meningoencephalitides attribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9892515c8052c8b4c2ba51d4dbbdf2
https://www.hal.inserm.fr/inserm-01931330/document