Výsledky vyhledávání - "Martine Berreur"

Oncostatin M, an Inflammatory Cytokine Produced by Macrophages, Supports Intramembranous Bone Healing in a Mouse Model of Tibia Injury

Autor: Frédéric Blanchard, Dominique Heymann, Anne-Laure Gamblin, Pierre Layrolle, Bénédicte Brounais-Le Royer, Jérôme Amiaud, Pierre J. Guihard, Audrey Renaud, Marie-Astrid Boutet, Martine Berreur, Françoise Rédini

Publikováno v: The American Journal of Pathology. 185:765-775

Different macrophage depletion strategies have demonstrated a vital role of macrophages in bone healing, but the underlying molecular mechanisms are poorly understood. Here, with the use of a mouse model of tibia injury, we found that the cytokine on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5764749150fcf1d3998f3e0d48168e
https://doi.org/10.1016/j.ajpath.2014.11.008

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Inhibition of BET proteins and epigenetic signaling as a potential treatment for osteoporosis

Autor: Jérôme Amiaud, Lidia Rodriguez Calleja, Marc Baud'huin, Benjamin Ory, Francois Lamoureux, James E. Bradner, Robert Owen, Thibaut Quillard, Martine Berreur, Camille Jacques, Gwendolen C. Reilly, Céline Charrier, Dominique Heymann, Bénédicte Brounais-LeRoyer

Publikováno v: BONE
BONE, 2017, 94, pp.10-21. ⟨10.1016/j.bone.2016.09.020⟩
BONE, Elsevier, 2017, 94, pp.10-21. ⟨10.1016/j.bone.2016.09.020⟩

International audience; Histone modifications are important for maintaining the transcription program. BET proteins, an important class of " histone reading proteins " , have recently been described as essential in bone biology. This study presents t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f49ea65a2eadbc4565191de2500b899
https://pubmed.ncbi.nlm.nih.gov/27669656

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Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells

Autor: Emmanuelle David, Françoise Rédini, Céline Chipoy, Virginie Ferré, Dominique Heymann, Valérie Trichet, Frédéric Blanchard, Bénédicte Brounais, Martine Berreur, Céline Charrier, Laurence Duplomb

Publikováno v: Bone. 44:830-839

Previous in vitro studies on primary osteoblastic and osteosarcoma cells (normal and transformed osteoblasts) have shown that oncostatin M (OSM), a member of the interleukin-6 family, possesses cytostatic and pro-apoptotic effects in association with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc44f64382180e42171f33d9897c28d
https://doi.org/10.1016/j.bone.2008.12.021

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Human osteosarcoma cells express functional receptor activator of nuclear factor‐kappa B

Autor: Anne Moreau, François Gouin, Catherine Chevalier, Martial Masson, Jérôme Guicheux, Anne Riet, Dominique Heymann, I Guisle-Marsollier, B. Le Goff, Frédéric Blanchard, Jean J. Leger, Kanji Mori, Françoise Rédini, Martine Berreur

Publikováno v: The Journal of Pathology. 211:555-562

RANK, RANK ligand (RANKL) and osteoprotegerin (OPG) are the key regulators of bone metabolism, both in normal and pathological conditions. Previous data have demonstrated that human osteosarcoma biopsies express RANKL as well as OPG, and functional R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9dbff0a0364832d0037a67bc86f0c0
https://doi.org/10.1002/path.2140

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Inhibition of osteolysis and increase of bone formation after local administration of siRNA-targeting RANK in a polyethylene particle-induced osteolysis model

Autor: Pierre Layrolle, Régis Brion, Luis A. Córdova, Valérie Trichet, Virginie Escriou, Martine Berreur, Séverine Battaglia, Philippe Rosset, François Gouin, Jérôme Amiaud, Céline Charrier, N Passuti, Dominique Heymann

Publikováno v: Acta Biomaterialia
Acta Biomaterialia, Elsevier, 2015, 13, pp.150-158. ⟨10.1016/j.actbio.2014.10.042⟩
Europe PubMed Central

International audience; Receptor activator of nuclear factor kappa-B (RANK) and RANK-ligand are relevant targets for the treatment of polyethylene particle-induced osteolysis. This study assessed the local administration of siRNA, targeting both huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04507913ab22b2e271d3e29727cc3c0d
https://hal-cnrs.archives-ouvertes.fr/hal-03292707

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Downregulation of Osteoblast Markers and Induction of the Glial Fibrillary Acidic Protein by Oncostatin M in Osteosarcoma Cells Require PKCδ and STAT3

Autor: Frédéric Blanchard, Dominique Heymann, Françoise Rédini, Céline Chipoy, Gilbert Pradal, Séverine Couillaud, Caroline Colombeix, Martine Berreur, François M. Vallette

Publikováno v: Journal of Bone and Mineral Research. 19:1850-1861

The effects of OSM on proliferation and differentiation of osteosarcoma and nontransformed osteoblasts were analyzed. OSM downregulates osteoblast markers but induces the glial fibrillary acidic protein by the combined activation of PKCδ and STAT3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afbb0f6e76b66d3475a742e78ba02a2
https://doi.org/10.1359/jbmr.040817

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Electron microscopy study of intrahepatic ultrasmall superparamagnetic iron oxide kinetics in the rat. Relation with magnetic resonance imaging

Autor: Benoît Dupas, Martine Berreur, Ramin Rohanizadeh, Bruno Bonnemain, Gilbert Pradal, Khaled Meflah

Publikováno v: Biology of the Cell. 91:195-208

Ultrasmall superparamagnetic iron oxide (USPIO) contrast agents for use in magnetic resonance imaging (MRI) are currently undergoing clinical evaluation. However, the images observed and the kinetic profiles obtained differ from one agent to another.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c689c7c37f46f83d38abf2bc24bcb499
https://doi.org/10.1016/s0248-4900(99)80042-2

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Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

Autor: James E. Bradner, Camille Jacques, Fernando Lecanda, Françoise Rédini, Marc Baud'huin, Lidia Rodriguez Calleja, Benjamin Ory, Francois Lamoureux, Martine Berreur, Dominique Heymann

Publikováno v: Nature communications. 5

The vicious cycle established between bone-associated tumours and bone resorption is the central problem with therapeutic strategies against primary bone tumours and bone metastasis. Here we report data to support inhibition of BET bromodomain protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bb957b910ef818fa59aab861c6013a
https://pubmed.ncbi.nlm.nih.gov/24646477

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A functional, new short isoform of death receptor 4 in Ewing's sarcoma cell lines may be involved in TRAIL sensitivity/resistance mechanisms

Autor: Franck Tirode, Françoise Rédini, Dominique Heymann, Catherine Pellat-Deceunynck, Sylvanie Surget, Romain Guiho, Gaelle Picarda, Martine Berreur, Stéphane Téletchéa, Valérie Trichet

Publikováno v: Molecular Cancer Research
Molecular Cancer Research, American Association for Cancer Research, 2012, 10 (3), pp.336-346. ⟨10.1158/1541-7786.MCR-11-0390⟩
Molecular Cancer Research, 2012, 10 (3), pp.336-346. ⟨10.1158/1541-7786.MCR-11-0390⟩

Ewing's sarcoma (ES) is a high-grade neoplasm arising in bones of children and adolescents. Survival rate decreases from greater than 50% to only 20% after 5 years for patients not responding to treatment or presenting metastases at diagnosis. TRAIL,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332560d15294e75fc3c56036ad845ac9
https://pubmed.ncbi.nlm.nih.gov/22258765

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