Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Martine Lapalus"'
1
Akademický článek
Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach
Autor: Mounia Lakli, Julie Dumont, Virginie Vauthier, Julie Charton, Veronica Crespi, Manon Banet, Yosra Riahi, Amel Ben Saad, Elodie Mareux, Martine Lapalus, Emmanuel Gonzales, Emmanuel Jacquemin, Florent Di Meo, Benoit Deprez, Florence Leroux, Thomas Falguières
Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract ABCB4 is located at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of this transporter are correlated with rare cholestatic liver diseases, the most severe be
Externí odkaz: https://doaj.org/article/15d3c2a95c39433cb086203c92b4dc08
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2
Akademický článek
Outcomes of 38 patients with PFIC3: Impact of genotype and of response to ursodeoxycholic acid therapy
Autor: Emmanuel Gonzales, Antoine Gardin, Marion Almes, Amaria Darmellah-Remil, Hanh Seguin, Charlotte Mussini, Stéphanie Franchi-Abella, Mathieu Duché, Oanez Ackermann, Alice Thébaut, Dalila Habes, Bogdan Hermeziu, Martine Lapalus, Thomas Falguières, Jean-Philippe Combal, Bernard Benichou, Sonia Valero, Anne Davit-Spraul, Emmanuel Jacquemin
Publikováno v: JHEP Reports, Vol 5, Iss 10, Pp 100844- (2023)
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long-t
Externí odkaz: https://doaj.org/article/5e41a2b0590743f2ae9ca730fde774d7
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3
Akademický článek
In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy
Autor: Elodie Mareux, Martine Lapalus, Amel Ben-Saad, Isabelle Callebaut, Thomas Falguières, Emmanuel Gonzales, Emmanuel Jacquemin
Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-4 (2021)
Abstract Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these co
Externí odkaz: https://doaj.org/article/2224e9e12283412f8afa4558224ab794
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5
Akademický článek
IFI35, mir-99a and HCV genotype to predict sustained virological response to pegylated-interferon plus ribavirin in chronic hepatitis C.
Autor: Emilie Estrabaud, Kevin Appourchaux, Ivan Bièche, Fabrice Carrat, Martine Lapalus, Olivier Lada, Michelle Martinot-Peignoux, Nathalie Boyer, Patrick Marcellin, Michel Vidaud, Tarik Asselah
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121395 (2015)
Although, the treatment of chronic hepatitis C (CHC) greatly improved with the use of direct antiviral agents, pegylated-interferon (PEG-IFN) plus ribavirin remains an option for many patients, worldwide. The intra-hepatic level of expression of inte
Externí odkaz: https://doaj.org/article/53a58c5073bc40cca8297d80aca14673
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6
In vitro functional rescue by ivacaftor of an ABCB11 variant involved in PFIC2 and intrahepatic cholestasis of pregnancy
Autor: Isabelle Callebaut, Martine Lapalus, Emmanuel Jacquemin, Emmanuel Gonzales, Elodie Mareux, Amel Ben-Saad, Thomas Falguières
Publikováno v: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-4 (2021)
Orphanet Journal of Rare Diseases, BioMed Central, 2021, 16 (1), ⟨10.1186/s13023-021-02125-4⟩
Orphanet Journal of Rare Diseases, 2021, 16 (1), ⟨10.1186/s13023-021-02125-4⟩
Background ABCB11 variations are responsible for a spectrum of rare liver diseases, including progressive familial intrahepatic cholestasis type 2 (PFIC2) and intrahepatic cholestasis of pregnancy (ICP). Current medical treatment of these conditions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614bdc2090d46fd5182ed9c95e581ced
https://pubmed.ncbi.nlm.nih.gov/34794484
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7
Effect of CFTR correctors on the traffic and the function of intracellularly retained ABCB4 variants
Autor: Ágota Tóth, Emmanuel Jacquemin, Isabelle Garcin, Jean-Louis Delaunay, Chantal Housset, Florent Di Meo, Angelika Janaszkiewicz, Alix Bruneau, Thomas Falguières, Martine Lapalus, Anne-Marie Durand-Schneider, Tounsia Aït-Slimane, Elodie Mareux, Emmanuel Gonzales, Virginie Vauthier, Amel Ben Saad
Publikováno v: Liver International
Liver International, Wiley-Blackwell, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
Liver International, 2021, 41 (6), pp.1344-1357. ⟨10.1111/liv.14839⟩
International audience; Background & aim: ABCB4 is expressed at the canalicular membrane of hepatocytes. This ATP-binding cassette (ABC) transporter is responsible for the secretion of phosphatidylcholine into bile canaliculi. Missense genetic variat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1d478a09ed70ab74550169e6e80f1e
https://hal.sorbonne-universite.fr/hal-03263358/document
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8
Molecular Regulation of Canalicular ABC Transporters
Autor: Amel, Ben Saad, Alix, Bruneau, Elodie, Mareux, Martine, Lapalus, Jean-Louis, Delaunay, Emmanuel, Gonzales, Emmanuel, Jacquemin, Tounsia, Aït-Slimane, Thomas, Falguières
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (4), pp.2113. ⟨10.3390/ijms22042113⟩
International Journal of Molecular Sciences, 2021, 22 (4), pp.2113. ⟨10.3390/ijms22042113⟩
International Journal of Molecular Sciences, Vol 22, Iss 2113, p 2113 (2021)
International audience; The ATP-binding cassette (ABC) transporters expressed at the canalicular membrane of hepatocytes mediate the secretion of several compounds into the bile canaliculi and therefore play a key role in bile secretion. Among these
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::80f29677e693bdb3225ad7ecc4a758a5
https://hal.sorbonne-universite.fr/hal-03163529
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