Zobrazeno 1 - 10
of 228
pro vyhledávání: '"Martine J. Smit"'
Autor:
Roman R. Schlimgen, Francis C. Peterson, Raimond Heukers, Martine J. Smit, John D. McCorvy, Brian F. Volkman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract G protein-coupled receptors (GPCRs) are pivotal therapeutic targets, but their complex structure poses challenges for effective drug design. Nanobodies, or single-domain antibodies, have emerged as a promising therapeutic strategy to target
Externí odkaz:
https://doaj.org/article/52636f4e898c4c9caf197813d718a9df
Autor:
Sander W Tas, Dieneke Schonenberg-Meinema, J Merlijn van den Berg, Sylvia Kamphuis, Marjan A Versnel, Mohamed Javad Wahadat, Sandy C Bergkamp, Amara Nassar-Sheikh Rashid, Mariken P Gruppen, Nick D Bergkamp, Martine J Smit
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss 2 (2024)
Objectives In childhood-onset SLE (cSLE), patients have an increased risk of premature atherosclerosis. The pathophysiological mechanisms for this premature atherosclerosis are not yet completely understood, but besides traditional risk factors, the
Externí odkaz:
https://doaj.org/article/5f9342529e30440fbdfe69e24f3bdd31
Autor:
Gamal A. Wakileh, Philipp Bierholz, Mara Kotthoff, Margaretha A. Skowron, Felix Bremmer, Alexa Stephan, Stephanie M. Anbuhl, Raimond Heukers, Martine J. Smit, Philipp Ströbel, Daniel Nettersheim
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2023)
Abstract Being stimulated by the chemokine CXCL12, the CXCR4 / CXCR7 cascade is involved in tumor proliferation, migration, and metastasis. The interaction between CXCL12, secreted by cells from the microenvironment, and its receptors is complex and
Externí odkaz:
https://doaj.org/article/7c03766aefb5452d89e9a05381e22674
Autor:
Justine S. Paradis, Xiang Feng, Brigitte Murat, Robert E. Jefferson, Badr Sokrat, Martyna Szpakowska, Mireille Hogue, Nick D. Bergkamp, Franziska M. Heydenreich, Martine J. Smit, Andy Chevigné, Michel Bouvier, Patrick Barth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.
Externí odkaz:
https://doaj.org/article/c0d899ae8609439f8ce39b8bdc95e8a4
Autor:
Maarten P. Bebelman, Irfan M. Setiawan, Nick D. Bergkamp, Jeffrey R. van Senten, Caitrin Crudden, Jan Paul M. Bebelman, Frederik J. Verweij, Guillaume van Niel, Marco Siderius, D. Michiel Pegtel, Martine J. Smit
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107412- (2023)
Summary: The human cytomegalovirus (HCMV)-encoded chemokine receptor US28 contributes to various aspects of the viral life cycle and promotes immune evasion by scavenging chemokines from the microenvironment of HCMV-infected cells. In contrast to the
Externí odkaz:
https://doaj.org/article/3584ed7d87864108bd8d9bb36453dd90
Autor:
Dehan Comez, Jacqueline Glenn, Stephanie M. Anbuhl, Raimond Heukers, Martine J. Smit, Stephen J. Hill, Laura E. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionThe Epidermal Growth Factor Receptor is a member of the Erb receptor tyrosine kinase family. It binds several ligands including EGF, betacellulin (BTC) and TGF-α, controls cellular proliferation and invasion and is overexpressed in vario
Externí odkaz:
https://doaj.org/article/05d30db7c8be4764811481e7f4448f13
Autor:
Timo W. M. De Groof, Elizabeth G. Elder, Eleanor Y. Lim, Raimond Heukers, Nick D. Bergkamp, Ian J. Groves, Mark Wills, John H. Sinclair, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Human cytomegalovirus (HCMV) can evade immune responses in latent reservoirs, which is a specific problem during transplantation. Here the authors develop a bivalent nanobody that is specific for US28, a viral receptor required by latent HCMV, and sh
Externí odkaz:
https://doaj.org/article/f6e7b525a9434aba8b55e7c5d8bcbd9e
Autor:
Timo W. M. De Groof, Nick D. Bergkamp, Raimond Heukers, Truc Giap, Maarten P. Bebelman, Richard Goeij-de Haas, Sander R. Piersma, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Marco Siderius, Martine J. Smit
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Various GPCRs display constitutive ligand-independent activity, but it remains unclear whether ligand-dependent and -independent conformations differ. Here the authors demonstrate the recognition and blocking of G protein recruitment of either the li
Externí odkaz:
https://doaj.org/article/e627ed6b73f44763bda4541f3d3a971b
Autor:
Mátyás A. Bittenbinder, Nick D. Bergkamp, Julien Slagboom, Jan Paul M. Bebelman, Nicholas R. Casewell, Marco H. Siderius, Martine J. Smit, Jeroen Kool, Freek J. Vonk
Publikováno v:
Biology, Vol 12, Iss 6, p 765 (2023)
Snakebite envenoming is an important public health issue with devastating consequences and annual mortality rates that range between 81,000 and 138,000. Snake venoms may cause a range of pathophysiological effects affecting the nervous system and the
Externí odkaz:
https://doaj.org/article/f9e79332668545178e61ab84f5cb989e
Autor:
Amos Fumagalli, Joyce Heuninck, Anne Pizzoccaro, Enora Moutin, Joyce Koenen, Martial Séveno, Thierry Durroux, Marie-Pierre Junier, Géraldine Schlecht-Louf, Francoise Bachelerie, Dagmar Schütz, Ralf Stumm, Martine J. Smit, Nathalie C. Guérineau, Séverine Chaumont-Dubel, Philippe Marin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The atypical chemokine receptor 3 (ACKR3) is known to regulate cell migration, but the underlying mechanisms are unclear. Here, the authors show, from an interactome analysis, ACKR3 association with the gap junction protein Connexin 43 in vivo and AC
Externí odkaz:
https://doaj.org/article/15da11b062db485fa8b9ce8e0b203220