Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Martine, Roudier"'
Autor:
Lauren Brady, Michelle Kriner, Ilsa Coleman, Colm Morrissey, Martine Roudier, Lawrence D. True, Roman Gulati, Stephen R. Plymate, Zoey Zhou, Brian Birditt, Rhonda Meredith, Gary Geiss, Margaret Hoang, Joseph Beechem, Peter S. Nelson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The inter- and intra-tumor heterogeneity of metastatic prostate cancer (mPC) is underexplored. Here the authors use Digital Spatial Profiling to study gene and protein expression heterogeneity in 27 mPC patients, finding variation in associated pathw
Externí odkaz:
https://doaj.org/article/e4f2a14a1c564697b67f91b5bef0c54e
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
A cluster analysis of adenocarcinoma and neuronal CRPC metastases (n=71). The CHGA+/SYP+ sites cluster together (highlighted in orange (AR+) and yellow (AR-)). Genes between CHGA- vs. CHGA+/SYP+ were compared and considered differentially expressed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7529d95eab92fa6304f50eb9a2a8b6f4
https://doi.org/10.1158/1078-0432.22461821
https://doi.org/10.1158/1078-0432.22461821
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
AgilentTM oligo array expression analysis of thirty-seven genes with >2.5-fold differential expression common to 5 CHGA+/SYP+/AR- and 5 CHGA+/SYP+/AR+ CRPC metastases when compared to 61 CHGA- or CHGA+/SYP- CRPC metastases. Mean-centered ratios of ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070400fe62c4f7380467785426dbf00f
https://doi.org/10.1158/1078-0432.22461815
https://doi.org/10.1158/1078-0432.22461815
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
(A) Hypothetical interactions between NE-associated transcription factors upregulated in CHGA+/SYP+/AR- tumors that promote the AR- NE phenotype. (B) A Venn diagram comparing genes with a SAM score >2.5 between CHGA- and CHGA+/SYP- metastases and CHG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abf5544d5b7711b1da367f9d86d79be
https://doi.org/10.1158/1078-0432.22461818
https://doi.org/10.1158/1078-0432.22461818
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
Purpose: The neuroendocrine phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the neuroendocrine phenotype in CRPC.Experimental Design:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab319fbcebd8f46cdbaf3582091b7722
https://doi.org/10.1158/1078-0432.c.6524915
https://doi.org/10.1158/1078-0432.c.6524915
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
(A) Representative examples of marker response by IHC for CHGA, SYP, and AR in CRPC bone metastases. 05-114: CHGA+/SYP+/AR-, 05-221: CHGA+/SYP+/AR- (white arrow), CHGA-/SYP-AR+ (black arrow). 07-042: CHGA+/SYP+AR+. Percent of (B) CHGA and (C) SYP pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e61d240dd384207065543c5be188ce3
https://doi.org/10.1158/1078-0432.22461824
https://doi.org/10.1158/1078-0432.22461824
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
(A) IHC and AgilentTM oligo array expression analysis of prostate and neuroendocrine-associated genes in 24 LuCaP xenograft lines. Mean-centered ratios of genes are colored according to scale (Supplemental Figure 2). LuCaP 49, 93, 145.1 and 145.2 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfd28ea77e50f24032302d9675dac55
https://doi.org/10.1158/1078-0432.22461809
https://doi.org/10.1158/1078-0432.22461809
Autor:
Colm Morrissey, Robert L. Vessella, Peter S. Nelson, Paul H. Lange, Martine Roudier, Bruce Montgomery, Celestia S. Higano, Bryce Lakely, Lisly Chéry, Eva Corey, Ruth Dumpit, Hung-Ming Lam, Jared M. Lucas, Lori Kollath, Lawrence D. True, Lisha G. Brown, Ilsa M. Coleman, Xiaotun Zhang
Supplemental tables 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b36793f21aec3cab8a9c0ecd9d0f7e
https://doi.org/10.1158/1078-0432.22461803.v1
https://doi.org/10.1158/1078-0432.22461803.v1
Autor:
Mohamed Adil, Brian Hanratty, Pallabi Mustafi, Ilsa Coleman, Radhika Patel, Anna-Lisa Doebley, Robert Patton, Eden Cruikshank, Patricia Galipeau, Ruth Dumpit, Martine Roudier, Jin-Yih Low, Navonil De Sarkar, Robert Montgomery, Eva Corey, Colm Morrissey, Peter Nelson, Gavin Ha, Michael Haffner
Publikováno v:
Cancer Research. 83:LB298-LB298
Introduction: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease which can be classified into clinically relevant subtypes based on the expression of transcription factors (TF), such as the androgen receptor (AR) and n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed5f4a18aebfcbf52d4192add6ed7d3
https://doi.org/10.1158/1538-7445.am2023-lb298
https://doi.org/10.1158/1538-7445.am2023-lb298
Autor:
William G. Nelson, Jonathan I. Epstein, Martine Roudier, Michael C. Haffner, Srinivasan Yegnasubramanian, Lawrence D. True, Peter S. Nelson, Wilbert Zwart, Angelo M. De Marzo
Publikováno v:
Nat Rev Urol
From a clinical, morphological and molecular perspective, prostate cancer is a heterogeneous disease. Primary prostate cancers are often multifocal, having topographically and morphologically distinct tumour foci. Sequencing studies have revealed tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45fe7ce0a7f64eca645c5e7ea76736e
https://doi.org/10.1038/s41585-020-00400-w
https://doi.org/10.1038/s41585-020-00400-w