A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models

Autor: Kamel Chettab, Chantel Fitzsimmons, Alexey Novikov, Morgane Denis, Capucine Phelip, Doriane Mathé, Pierre Antoine Choffour, Sabine Beaumel, Eric Fourmaux, Patrick Norca, David Kryza, Anne Evesque, Lars Petter Jordheim, Emeline Perrial, Eva-Laure Matera, Martine Caroff, Jerome Kerzerho, Charles Dumontet

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Bacterial lipopolysaccharides (LPS) are potent innate immunostimulants targeting the Toll-like receptor 4 (TLR4), an attractive and validated target for immunostimulation in cancer therapy. Although LPS possess anti-tumor activity, toxicity issues pr

Externí odkaz: https://doaj.org/article/117d1de624a6452abc1b619b93a387d8

Leptospiral LPS escapes mouse TLR4 internalization and TRIF‑associated antimicrobial responses through O antigen and associated lipoproteins.

Autor: Delphine Bonhomme, Ignacio Santecchia, Frédérique Vernel-Pauillac, Martine Caroff, Pierre Germon, Gerald Murray, Ben Adler, Ivo G Boneca, Catherine Werts

Publikováno v: PLoS Pathogens, Vol 16, Iss 8, p e1008639 (2020)

Leptospirosis is a worldwide re-emerging zoonosis caused by pathogenic Leptospira spp. All vertebrate species can be infected; humans are sensitive hosts whereas other species, such as rodents, may become long-term renal carrier reservoirs. Upon infe

Externí odkaz: https://doaj.org/article/68990ecb9d1b45879602e55bb8b37da2

Structural characterization of Bordetella parapertussis lipid A

Autor: Asmaa El Hamidi, Alexey Novikov, Doris Karibian, Malcolm B. Perry, Martine Caroff

Publikováno v: Journal of Lipid Research, Vol 50, Iss 5, Pp 854-859 (2009)

Bordetella parapertussis like B. pertussis, is a causal agent of whooping cough but is not a strictly human pathogen. Because its endotoxin, a major structural component of the Gram-negative outer membrane, is an important virulence factor, we have a

Externí odkaz: https://doaj.org/article/b2183d23438841a5904b367c42c01d19

Microextraction of bacterial lipid A: easy and rapid method for mass spectrometric characterization

Autor: Asmaa El Hamidi, Alina Tirsoaga, Alexey Novikov, Ahmed Hussein, Martine Caroff

Publikováno v: Journal of Lipid Research, Vol 46, Iss 8, Pp 1773-1778 (2005)

Endotoxins (lipopolysaccharides) are the main components of Gram-negative bacterial outer membranes. A quick and simple way to isolate their lipid region (lipid A) directly from whole bacterial cells was devised. This method using hot ammonium-isobut

Externí odkaz: https://doaj.org/article/15af3f5e1396498f9f82f807baaba0b5

Structure function relationships in three lipids A from the Ralstonia genus rising in obese patients

Autor: Alexey Novikov, Wei Zhang-Sun, François Tercé, Matteo Serino, Rémy Burcelin, Martine Caroff

Publikováno v: Biochimie 159, 72-80. (2019)
Biochimie
Biochimie, Elsevier, 2019, 159 (159), pp.72-80. ⟨10.1016/j.biochi.2019.01.015⟩
Biochimie, Elsevier, 2019, 159, pp.72--80. ⟨10.1016/j.biochi.2019.01.015⟩
Biochimie, 2019, 159 (159), pp.72-80. ⟨10.1016/j.biochi.2019.01.015⟩

International audience; The identification of a functional molecular moiety relating the lipopolysaccharides (LPSs) to their capacity to induce inflammation-mediated metabolic diseases needed to be performed. We previously described a proportional in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd33b327c1a21853392bfbc09189244
https://doi.org/10.1016/j.biochi.2019.01.015