423 Single cell RNA sequencing reveals functionally validated signatures of cytotoxicity in anti-FRα CoStimulatory Antigen Receptor (CoStARTM) activated CD4+ T cells

Autor: Mark Dudley, Gray Kueberuwa, John S Bridgeman, Martina Sykorova, Leyuan Bao, Robert E Hawkins, Katrina Sherbina Baklan, Owen Moon, Jinzhou Yuan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/094bf09ba2824d2f89844cf2d61005e0

Signaling via a CD28/CD40 chimeric costimulatory antigen receptor (CoStAR™), targeting folate receptor alpha, enhances T cell activity and augments tumor reactivity of tumor infiltrating lymphocytes

Autor: Milena Kalaitsidou, Owen R. Moon, Martina Sykorova, Leyuan Bao, Yun Qu, Sujita Sukumaran, Michael Valentine, Xingliang Zhou, Veethika Pandey, Kay Foos, Sergey Medvedev, Daniel J. Powell Jr, Akshata Udyavar, Eric Gschweng, Ruben Rodriguez, Mark E. Dudley, Robert E. Hawkins, Gray Kueberuwa, John S. Bridgeman

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However, extending the clinical benefit to patients with other cancers poses a challenge. Inefficient

Externí odkaz: https://doaj.org/article/7f1e15ebf5834e83a34fa2733d953fd0

Factors Predicting Limb Volume Reduction Using Compression Bandaging Within Decongestive Lymphatic Therapy in Lymphedema: A Multicountry Prospective Study

Autor: Tonny Karlsmark, Susie Murray, Peter Franks, Isabelle Quéré, Andrea Tilley, Ewa A Burian, Christine J. Moffatt, Martina Sykorova, Stéphane Vignes, Max Emanuel Liebl, Vaughan Keeley, Sophie Doiron, A. Reißhauer

Publikováno v: Moffatt, C J, Burian, E, Karlsmark, T, Keeley, V, Vignes, S, Doiron, S, Tilley, A, Liebl, M, Reißhauer, A, Murray, S, Sykorova, M, Quéré, I & Franks, P J 2021, ' Factors Predicting Limb Volume Reduction Using Compression Bandaging within Decongestive Lymphatic Therapy in Lymphedema : A Multicountry Prospective Study ', Lymphatic Research and Biology, vol. 19, no. 5, pp. 412-422 . https://doi.org/10.1089/lrb.2021.0060

Objectives: To identify predictive factors associated with limb volume reduction using different decongestive lymphatic therapy (DLT) systems in patients with lymphoedema, over a period of up to 28 days. Methods: A multicountry (Canada, France, Germa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6679aabb28318304321e12c7fe8d9945
https://doi.org/10.1089/lrb.2021.0060

199 Potent T cell costimulation mediated by a novel costimulatory antigen receptor (CoStAR) with dual CD28/CD40 signaling domains to improve adoptive cell therapies

Autor: Milena Kalaitsidou, Rubén Alvarez-Rodríguez, Leyuan Bao, Michelle Le Brocq, John S. Bridgeman, Gray Kueberuwa, Robert E. Hawkins, Martina Sykorova, Cynthia Chauvin-Fleurence

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundCostimulatory signals are a critical component to mount an effective anti-tumor response. Prolonged TCR stimulation in the absence of costimulatory signals can lead to T cell anergy and dysfunction. The tumor microenvironment evades immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a505aa8fb169dbfd73bbd94ce791fdc
https://doaj.org/article/6f779466d27945fa941585ad8a6bdd18

Clinical and Ethical Challenges in Undertaking LIMPRINT in Vulnerable Populations

Autor: Sarah Pankhurst, Isabelle Quéré, Gregoire Mercier, Rachel Bussey, Susie Murray, Martina Sykorova, Siobhan Whiston, Susan Gordon, Aimee Aubeeluck, Peter Franks, Christine Moffatt

Publikováno v: Lymphatic Research and Biology
Lymphatic Research and Biology, Mary Ann Liebert, 2019, 17 (2), pp.155--162. ⟨10.1089/lrb.2018.0083⟩

International audience; Background and Study Objective: To estimate the prevalence of chronic edema (CO) and wounds within two vulnerable populations, a male high security prison in the East Midlands (United Kingdom) and residential and nursing homes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5aee8fdfb8f3fa3cbc32dca2504f551
https://doi.org/10.1089/lrb.2018.0083