Výsledky vyhledávání - "Martina Streiber"

Methyl esters of N‐(dicyclohexyl)acetyl‐piperidine‐4‐(benzylidene‐4‐carboxylic acids) as drugs and prodrugs: A new strategy for dual inhibition of 5α‐reductase type 1 and type 2

Autor: Franck Picard, Christiane Scherer, Martina Streiber, Stefanie B. Seidel, Rolf W. Hartmann

Publikováno v: Journal of Pharmaceutical Sciences. 94:473-480

Steroid 5alpha-reductase (5alphaR) inhibitory potency of three N-(dicyclohexyl)acetyl-piperidine-4-(benzylidene-4-carboxylic acids) and their corresponding methyl esters was monitored for type 2 isoenzyme in a benign prostatic hyperplasia cell free p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a49fec086dd4ec0d7521856d67f130a
https://doi.org/10.1002/jps.20265

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Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids

Autor: Ola I. A. Salem, Martina Streiber, Alexander Neugebauer, Christiane Scherer, Ruth Maria Maas, Martin Frotscher, Rolf W. Hartmann, Klaus Biemel

Publikováno v: Journal of medicinal chemistry. 49(2)

Novel substituted benzoyl benzoic acids and phenylacetic acids 1-14 have been synthesized and evaluated for inhibition of rat and human steroid 5alpha-reductase isozymes 1 and 2. The compounds turned out to be potent and selective human type 2 enzyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054f29ba03419a8a5c961a6aada5a012
https://pubmed.ncbi.nlm.nih.gov/16420060

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