Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Martina Soldemo"'
Autor:
Martina Soldemo, Monika Àdori, Julian M. Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T. Wyatt, Gunilla B. Karlsson Hedestam
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers.
Externí odkaz:
https://doaj.org/article/57b13493f6894919baa94210f047d8fb
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Antibodies are central in vaccine-mediated protection. For HIV-1, a pathogen that displays extreme antigenic variability, B cell responses against conserved determinants of the envelope glycoproteins (Env) are likely required to achieve broadly prote
Externí odkaz:
https://doaj.org/article/ed63221adc5945bda2424070af98da17
Publikováno v:
Viruses, Vol 6, Iss 9, Pp 3400-3414 (2014)
Continued efforts to define the immunogenic properties of the HIV-1 envelope glycoproteins (Env) are needed to elicit effective antibody (Ab) responses by vaccination. HIV-1 is a highly neutralization-resistant virus due to conformational and glycan
Externí odkaz:
https://doaj.org/article/5cd917aaa95b43e39b1f7c924562d449
Autor:
Marjon Navis, Karen Tran, Shridhar Bale, Ganesh E Phad, Javier Guenaga, Richard Wilson, Martina Soldemo, Krisha McKee, Christopher Sundling, John Mascola, Yuxing Li, Richard T Wyatt, Gunilla B Karlsson Hedestam
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004337 (2014)
Broadly neutralizing antibodies (bNAbs) isolated from chronically HIV-1 infected individuals reveal important information regarding how antibodies target conserved determinants of the envelope glycoprotein (Env) spike such as the primary receptor CD4
Externí odkaz:
https://doaj.org/article/289e6f4825134e2bbb14054f8c6cd1b0
Autor:
Richard K. Wilson, Lifei Yang, Gunilla B. Karlsson Hedestam, Martina Soldemo, Javier Guenaga, Yu Feng, Julian M. Stark, Karen Tran, Richard T. Wyatt, Monika Adori
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0fdf66bc4da617eeda1e72423e27fd
https://doi.org/10.3389/fimmu.2017.01654
https://doi.org/10.3389/fimmu.2017.01654
Autor:
Gunilla B. Karlsson Hedestam, Mikael C. I. Karlsson, Richard T. Wyatt, Pia Dosenovic, Mattias N. E. Forsell, Martina Soldemo
Publikováno v:
The Journal of Immunology. 191:44-51
Abs that bind the functional envelope glycoprotein (Env) spike are considered critical for a broadly effective prophylactic HIV-1 vaccine. The difficulty in eliciting such Abs by vaccination is partially attributed to the immunodominance of hydrophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ae75fa90609d12b7fd435a3dbdeef8
https://doi.org/10.4049/jimmunol.1203087
https://doi.org/10.4049/jimmunol.1203087
Autor:
Karin Loré, Gunilla B. Karlsson Hedestam, Martina Soldemo, Anna Smed-Sörensen, Leif Perbeck, Mattias N. E. Forsell, Richard A. Koup, William C. Adams, Kerrie J. Sandgren, Richard T. Wyatt, Frank Liang
Publikováno v:
The Journal of Immunology. 191:60-69
Advances in HIV-1 vaccine clinical trials and preclinical research indicate that the virus envelope glycoproteins (Env) are likely to be an essential component of a prophylactic vaccine. Efficient Ag uptake and presentation by dendritic cells (DCs) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef66f84687afe0b29b0a41f626a6669
https://doi.org/10.4049/jimmunol.1202489
https://doi.org/10.4049/jimmunol.1202489
Autor:
Christopher Sundling, Paola Martinez, Mats Spångberg, Martina Soldemo, Linda Stertman, Karin Lövgren Bengtsson, Mattias N. E. Forsell, Gunilla B. Karlsson Hedestam
Publikováno v:
The Journal of Infectious Diseases. 207:426-431
The envelope glycoproteins (Env) represent a critical component of a successful antibody-mediated human immunodeficiency virus type 1 (HIV-1) vaccine. However, immunization with soluble Env was reported to induce short-lived antibody responses, sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3b0b5be12a61eda68352e38747dfb6
https://doi.org/10.1093/infdis/jis696
https://doi.org/10.1093/infdis/jis696
Autor:
John R. Mascola, Gunilla B. Karlsson Hedestam, Pia Dosenovic, Sijy O'Dell, Mikael C. I. Karlsson, Nadège Pelletier, Martina Soldemo, Jean L. Scholz, Emilie K. Grasset, Michael P. Cancro, Richard T. Wyatt
Publikováno v:
The Journal of Immunology. 188:6018-6026
Neutralizing Abs provide the protective effect of the majority of existing human vaccines. For a prophylactic vaccine against HIV-1, broadly neutralizing Abs targeting conserved epitopes of the viral envelope glycoproteins (Env) are likely required,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7cf456e98f3643944703e094b0ddb2
https://doi.org/10.4049/jimmunol.1200466
https://doi.org/10.4049/jimmunol.1200466
Autor:
Iyadh Douagi, Martina Soldemo, Bimal K. Chakrabarti, Richard T. Wyatt, Adhuna Phogat, Gunilla B. Karlsson Hedestam, Staffan Paulie, Yuxing Li, Pia Dosenovic, Mattias N. E. Forsell, James A. Hoxie
Publikováno v:
The Journal of Immunology. 183:3373-3382
The HIV-1 envelope glycoprotein (Env) functional spike has evolved multiple immune evasion strategies, and only a few broadly neutralizing determinants on the assembled spike are accessible to Abs. Serological studies, based upon Ab binding and neutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c19b7f81fb14d613c645585363683f87
https://doi.org/10.4049/jimmunol.0900407
https://doi.org/10.4049/jimmunol.0900407