Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Martina Schmickl"'
Autor:
Simon Heidegger, Alexander Jarosch, Martina Schmickl, Stefan Endres, Carole Bourquin, Christian Hotz
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142523 (2015)
Mycoplasma are a frequent and occult contaminant of cell cultures, whereby these prokaryotic organisms can modify many aspects of cell physiology, rendering experiments that are conducted with such contaminated cells problematic. Chronic Mycoplasma c
Externí odkaz:
https://doaj.org/article/27477aa542cc4690965803c5970cfbff
Autor:
Simon Heidegger, Julius C. Fischer, Christian Peschel, Maike Kober, Xian Chang Li, Marc Schmidt-Supprian, Vera Otten, Hendrik Poeck, Marc Rosenbaum, Christoph Drees, Tobias Haas, Silvia Spoerl, Martina Schmickl, Geert van Loo, Rudi Beyaert
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950)
Maintaining immune tolerance requires the production of Foxp3-expressing regulatory T (Treg) cells in the thymus. Activation of NF-κB transcription factors is critically required for Treg cell development, partly via initiating Foxp3 expression. NF-
Autor:
Tobias Haas, Christian Peschel, Hendrik Poeck, Julius C. Fischer, Katja Steiger, Geert van Loo, Rudi Beyaert, Julia Slotta-Huspenina, Martina Schmickl, Silvia Spoerl, Vera Otten
Publikováno v:
European Journal of Immunology. 47:1982-1988
The NF-κB regulator A20 limits inflammation by providing negative feedback in myeloid cells and B cells. Functional lack of A20 has been linked to several inflammatory and autoimmune diseases. To define how A20 affects the functionality of T effecto
Autor:
Michael Bscheider, Julius C. Fischer, Tobias Haas, Alexander Wintges, Hendrik Poeck, Christian Peschel, Jürgen Ruland, Gabriel Eisenkolb, Sarah Bek, Martina Schmickl, Simon Heidegger, Silvia Spoerl
Publikováno v:
European Journal of Immunology
Activation of the C-type lectin receptor Dectin-1 by β-glucans triggers multiple signals within DCs that result in activation of innate immunity. While these mechanisms can potently prime CD8+ cytotoxic T-cell (CTL) responses without additional adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f47855e2d822f7c3007ff58726a97e2
https://mediatum.ub.tum.de/1445899
https://mediatum.ub.tum.de/1445899
Autor:
Jürgen Finke, Tony A. Mueller, Sophia Chen, Mareike Verbeek, Julius C. Fischer, Michael Bscheider, Annette Schmitt-Graeff, Nikolas von Bubnoff, Hendrik Poeck, Christian Peschel, Vera Otten, Silvia Spoerl, Martina Schmickl, Justus Duyster, Nimitha R. Mathew, Kristina Maas-Bauer, Robert Zeiser
Publikováno v:
Blood. 123:3832-3842
Graft-versus-host-disease (GVHD) is a severe complication of allogeneic hematopoietic cell transplantation (allo-HCT) characterized by the production of high levels of proinflammatory cytokines. Activated Janus kinases (JAKs) are required for T-effec
Autor:
Christian Hotz, Carole Bourquin, Stefan Endres, Simon Heidegger, Alexander Jarosch, Martina Schmickl
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142523 (2015)
PLoS ONE
PLoS ONE
Mycoplasma are a frequent and occult contaminant of cell cultures, whereby these prokaryotic organisms can modify many aspects of cell physiology, rendering experiments that are conducted with such contaminated cells problematic. Chronic Mycoplasma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a843c32c3093de71580978ce01ea8c
https://mediatum.ub.tum.de/doc/1351710/document.pdf
https://mediatum.ub.tum.de/doc/1351710/document.pdf
Autor:
Alexander Wintges, Simon Heidegger, Sarah Bek, Paul-Albert Koenig, Hendrik Poeck, Julius C. Fischer, Martina Schmickl, Tobias Haas
Publikováno v:
Journal of Clinical Oncology. 36:3081-3081
3081Background: Strong inter-individual variation in clinical response to immune checkpoint inhibitors (ICB) including anti-CTLA-4 remains a major challenge, but the molecular pathways that modulat...
Autor:
Martina Schmickl, Simon Heidegger, Tobias Haas, Christian Peschel, Alexander Wintges, Sarah Bek, Hendrik Poeck, Marcel R.M. van den Brink, Jürgen Ruland
Publikováno v:
Blood. 130:693-693
Strong inter-individual variation in clinical response to checkpoint inhibitors such as anti-CTLA-4 remains a major challenge. In a retrospective analysis, expression of viral defense genes in human melanomas including the cytosolic RNA receptor RIG-
Autor:
Diana Kreppel, Martina Schmickl, Michael Bscheider, Alexander Wintges, Marcel R.M. van den Brink, Simon Heidegger, Hendrik Poeck, Sarah Bek, Tobias Haas, Christian Peschel
Publikováno v:
Cancer Immunology Research. 4:A005-A005
Introduction: Targeting inhibitory T-cell receptors such as CTLA-4 has shown great promise in cancer therapy. However, strong inter-individual variation in clinical response to checkpoint inhibitors remains a major challenge. Expression of viral defe
Autor:
Christian Peschel, Martina Schmickl, Diana Kreppel, Michael Bscheider, Simon Heidegger, Jürgen Ruland, Tobias Haas, Marcel R.M. van den Brink, Alexander Wintges, Sarah Bek, Hendrik Poeck
Publikováno v:
Blood. 126:3436-3436
Antibody-mediated targeting of regulatory T cell receptors such as CTLA-4 has been shown to enhance anti-tumor immune responses against several cancer entities including malignant melanoma. Yet, therapeutic success in patients remains variable unders