Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Martina Schifferer"'
Autor:
Jianping Wu, Georg Kislinger, Jerome Duschek, Ayşe Damla Durmaz, Benedikt Wefers, Ruoqing Feng, Karsten Nalbach, Wolfgang Wurst, Christian Behrends, Martina Schifferer, Mikael Simons
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Oligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these l
Externí odkaz:
https://doaj.org/article/f28eec2219ca4b7681ec78bfd6b3f021
Autor:
Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TDP-43 animal models re
Externí odkaz:
https://doaj.org/article/3a903ab063944d74afd22278e76a4d88
Autor:
Georg Kislinger, Gunar Fabig, Antonia Wehn, Lucia Rodriguez, Hanyi Jiang, Cornelia Niemann, Andrey S Klymchenko, Nikolaus Plesnila, Thomas Misgeld, Thomas Müller-Reichert, Igor Khalin, Martina Schifferer
Publikováno v:
eLife, Vol 12 (2024)
Like other volume electron microscopy approaches, automated tape-collecting ultramicrotomy (ATUM) enables imaging of serial sections deposited on thick plastic tapes by scanning electron microscopy (SEM). ATUM is unique in enabling hierarchical imagi
Externí odkaz:
https://doaj.org/article/fdde08b96f784ce684b588b47341e556
Autor:
Peter Androvic, Martina Schifferer, Katrin Perez Anderson, Ludovico Cantuti-Castelvetri, Hanyi Jiang, Hao Ji, Lu Liu, Garyfallia Gouna, Stefan A. Berghoff, Simon Besson-Girard, Johanna Knoferle, Mikael Simons, Ozgun Gokce
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Understanding the complexity of cellular function within a tissue necessitates the combination of multiple phenotypic readouts. Here, we developed a method that links spatially-resolved gene expression of single cells with their ultrastructu
Externí odkaz:
https://doaj.org/article/c66140bd92484a63acc14ed3e67b9854
Autor:
Mihai Ancău, Goutam Kumar Tanti, Vicki Marie Butenschoen, Jens Gempt, Igor Yakushev, Stephan Nekolla, Mark Mühlau, Christian Scheunemann, Sebastian Heininger, Benjamin Löwe, Erik Löwe, Silke Baer, Johannes Fischer, Judith Reiser, Sai S. Ayachit, Friederike Liesche-Starnecker, Jürgen Schlegel, Kaspar Matiasek, Martina Schifferer, Jan S. Kirschke, Thomas Misgeld, Tim Lueth, Bernhard Hemmer
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104982- (2024)
Summary: Background: Inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic advances. Current murine models of remyelination have limited
Externí odkaz:
https://doaj.org/article/4152d6937b1f43938faedc49f705b2f9
Autor:
Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- and nonsense mutations in the gene encoding for Tectonin β-propeller repeat containing protein 2 (TECPR2). While TECPR2 is required fo
Externí odkaz:
https://doaj.org/article/6842faee2f4848b893cd13b63561bcca
Autor:
Dingxi Zhou, Mariana Borsa, Daniel J. Puleston, Susanne Zellner, Jesusa Capera, Sharon Sanderson, Martina Schifferer, Svenja S. Hester, Xin Ge, Roman Fischer, Luke Jostins, Christian Behrends, Ghada Alsaleh, Anna Katharina Simon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Autophagy is known to impact CD4+ T cell proliferation but the identity of autophagosomal components remain unclear. Here the authors leverage a transgenic mouse model to assess the autophagosomal compartment and identify interleukin-7 receptor-α as
Externí odkaz:
https://doaj.org/article/1ccb857c105547c5b33bd8c47532fb9e
Autor:
Karsten Nalbach, Martina Schifferer, Debjani Bhattacharya, Hung Ho-Xuan, Wei Chou Tseng, Luis A. Williams, Alexandra Stolz, Stefan F. Lichtenthaler, Zvulun Elazar, Christian Behrends
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/05c3dec578b84c7e8af33860749eca5a
Autor:
Martina Arends, Melanie Weber, Cyrus Papan, Markus Damm, Michal A. Surma, Christopher Spiegel, Minou Djannatian, Shengrong Li, Lisa Connell, Ludger Johannes, Martina Schifferer, Christian Klose, Mikael Simons
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105323- (2022)
Summary: Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known. Here, we present a direct infusion (shotgun) lipidomics method to an
Externí odkaz:
https://doaj.org/article/dac704c314c64c368965ca0de5ef3011
Autor:
Alessio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastian Monasor, Martina Schifferer, Ludovico Cantuti-Castelvetri, Jasmin König, Lea Vidatic, Tatiana Bremova-Ertl, Andrew P. Lieberman, Silva Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Strupp, Susanne A. Schneider, Sabina Tahirovic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial fu
Externí odkaz:
https://doaj.org/article/086477f8dbac4c818ed45236ab495029