Foresight in clinical proteomics: current status, ethical considerations, and future perspectives [version 1; peer review: 2 approved]

Autor: Filip Mundt, Sebastian Porsdam Mann, Nicolai J. Wewer Albrechtsen, Medini Ghodgaonkar-Steger, Peter Treit, Reinout Raijmakers, Martina O’Flaherty, Albert J.R. Heck, Juan Antonio Vizcaíno, Matthias Mann

Publikováno v: Open Research Europe, Vol 3 (2023)

With the advent of robust and high-throughput mass spectrometric technologies and bioinformatics tools to analyze large data sets, proteomics has penetrated broadly into basic and translational life sciences research. More than 95% of FDA-approved dr

Externí odkaz: https://doaj.org/article/414f3e7d31fd4a8d8506e4105d106b7a

Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium

Autor: Vera van Noort, Shabaz Mohammed, Martina O'Flaherty, Runjun D. Kumar, Arne Schmeisky, Peer Bork, Albert J. R. Heck, Robert B. Russell, Jörg Stülke, Sebastian Kühner, Ivana Vonkova, Tobias Maier, Anne-Claude Gavin, Eva Yus, Luis Serrano, Jan Seebacher, Matthew J. Betts, Vladimir Rybin, Samuel Bader

Publikováno v: Molecular Systems Biology
Molecular Systems Biology, Vol. 8, No 1 (2012) P. 571

The effect of kinase, phosphatase and N-acetyltransferase deletions on proteome phosphorylation and acetylation was investigated in Mycoplasma pneumoniae. Bi-directional cross-talk between post-transcriptional modifications suggests an underlying reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06a1f012f9ed4551918709c10e5a9f7
https://ora.ox.ac.uk/objects/uuid:06bf88fb-cd75-448a-96c1-4b3e67ceb8c2

Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis

Autor: Ruud H. Brakenhoff, Albert J. R. Heck, Jeroen W. A. Jansen, Serge J. Smeets, Monique Slijper, Martina O'Flaherty, Tieneke B.M. Schaaij-Visser

Publikováno v: Visser, B M, Brakenhoff, R H, Jansen, J L, O'Flaherty, M C, Smeets, S J, Heck, A J & Slijper, M 2009, ' Comparative proteome analysis to explore p53 pathway disruption in head and neck carcinogenesis ', Journal of Proteomics, vol. 72, no. 5, pp. 803-814 . https://doi.org/10.1016/j.jprot.2009.05.001
Journal of Proteomics, 72(5), 803-814. Elsevier

The 5-year-survival rate of head and neck squamous cell carcinoma (HNSCC) has been only moderately improved over the last few decades. HNSCC develops in precursor fields of genetically altered mucosal cells, typically characterized by p53 pathway dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57628329b25abe393d6d4546abeaea0e
https://doi.org/10.1016/j.jprot.2009.05.001

Probing the Membrane Interface-Interacting Proteome Using Photoactivatable Lipid Cross-Linkers

Autor: Pieter Vader, Martina O'Flaherty, Jacob Gubbens, A. I. P. M. De Kroon, B. de Kruijff, J.M.A. Damen, Monique Slijper

Publikováno v: Journal of Proteome Research. 6:1951-1962

To analyze proteins interacting at the membrane interface, a phospholipid analogue was used with a photoactivatable headgroup (ASA-DLPE, N-(4-azidosalicylamidyl)-1,2-dilauroyl-sn-glycero-3-phosphoethanolamine) for selective cross-linking. The periphe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653f823c91b328e8a066b18084da0d1d
https://doi.org/10.1021/pr060561a

Peptides with antimicrobial activity from four different families isolated from the skins of the North American frogs Rana luteiventris, Rana berlandieri and Rana pipiens

Autor: J. Michael Conlon, Zhihong Li, Floyd C. Knoop, Martina O'Flaherty, Jadvinder Goraya, James E. Platz, Yuqi Wang

Publikováno v: European Journal of Biochemistry. 267:894-900

The skins of frogs of the genus Rana synthesize a complex array of antimicrobial peptides that may be grouped into eight families on the basis of structural similarity. A total of 24 peptides with differential growth-inhibitory activity towards the G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e5a3769aabbfb407afbcaeaa3a39b7d
https://doi.org/10.1046/j.1432-1327.2000.01074.x