Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Martina Nibbio"'
Autor:
Alessandra Guidi, Cristiana Lalli, Emerald Perlas, Giulia Bolasco, Martina Nibbio, Edith Monteagudo, Alberto Bresciani, Giovina Ruberti
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 8, p e0004928 (2016)
Schistosomiasis, one of the world's greatest human neglected tropical diseases, is caused by parasitic trematodes of the genus Schistosoma. A unique feature of schistosome biology is that the induction of sexual maturation as well as the maintenance
Externí odkaz:
https://doaj.org/article/60eb0a8fc97547b48dcf02cad2e684e1
Autor:
Alessia Petrocchi, Alessandro Grillo, Luca Ferrante, Pietro Randazzo, Adolfo Prandi, Marilenia De Matteo, Costanza Iaccarino, Monica Bisbocci, Antonella Cellucci, Cristina Alli, Martina Nibbio, Vincenzo Pucci, Jérôme Amaudrut, Christian Montalbetti, Carlo Toniatti, Romano Di Fabio
Publikováno v:
ACS Medicinal Chemistry Letters. 14:645-651
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4e571165fa68cb8672ae130c497fda
https://doi.org/10.1021/acsmedchemlett.3c00059
https://doi.org/10.1021/acsmedchemlett.3c00059
Autor:
Esther Torrente, Valentina Fodale, Alina Ciammaichella, Federica Ferrigno, Jesus M. Ontoria, Simona Ponzi, Ilaria Rossetti, Alessio Sferrazza, Jérôme Amaudrut, Antonino Missineo, Simone Esposito, Simone Palombo, Martina Nibbio, Mauro Cerretani, Monica Bisbocci, Antonella Cellucci, Annalise di Marco, Cristina Alli, Vincenzo Pucci, Carlo Toniatti, Alessia Petrocchi
Publikováno v:
ACS Medicinal Chemistry Letters. 14:156-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6897f93fa03f3115ac19fe47da452c3
https://doi.org/10.1021/acsmedchemlett.2c00454
https://doi.org/10.1021/acsmedchemlett.2c00454
Autor:
Vinod Khetarpal, Catherine Greenaway, Samantha Ensor, Randall Davis, Michael Conlon, Andrea Varrone, Frank Herrmann, Laura Orsatti, Xuemei Chen, Martina Nibbio, Christer Halldin, Vladimir Stepanov, Simone Esposito, Daniel Clark-Frew, Ladislav Mrzljak, Christoph Scheich, Sabine Schaertl, Todd Herbst, Ming Min Hsai, Peter Johnson, Samuel Coe, Jonathan Bard, John Wityak, Michael Prime, Katarina Varnäs, Adrian Kotey, Lee Matthew, Sangram Nag, Manuela Heßmann, Celia Dominguez, Samantha Green, James C. Haber, Xinjie Gai, Longbin Liu, Edith Monteagudo, Anton Forsberg Morén, John E. Mangette, Christopher J. Brown, Matthew R. Mills, Ignacio Munoz-Sanjuan, Joanne Sproston, Sarah Hayes
Publikováno v:
Journal of Medicinal Chemistry. 64:12003-12021
The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington's disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bf0795aa450250464e8592df8acb66
https://doi.org/10.1021/acs.jmedchem.1c00667
https://doi.org/10.1021/acs.jmedchem.1c00667
Autor:
Maria Rosaria Battista, Rajhans Sharma, Yves Mély, Marisabella Santoriello, Edith Monteagudo, Paola Fezzardi, Eleonore Real, Maurizio Zazzi, Vincenzo Summa, Mattia Mori, Maria Chiara Dasso Lang, Steven J. Harper, Savina Malancona, Antonella Cellucci, Manuel Pires, Martina Nibbio, Maurizio Botta, Roberto Speziale, Andreina Basta, Nadia Gennari, Francesco Saladini, Davide De Forni, Annalise Di Marco, Alessia Giannini, Lesia Kovalenko
Publikováno v:
ACS Med Chem Lett
[Image: see text] The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bca7f5ccee8b2fa882bee58c45c157f
https://doi.org/10.1021/acsmedchemlett.9b00608
https://doi.org/10.1021/acsmedchemlett.9b00608
Autor:
Pietro Randazzo, Roberta Sinisi, Davide Gornati, Stefania Bertuolo, Leda Bencheva, Marilenia De Matteo, Martina Nibbio, Edith Monteagudo, Lorenzo Turcano, Valeria Bianconi, Giovanna Peruzzi, Vincenzo Summa, Alberto Bresciani, Chiara Mozzetta, Romano Di Fabio
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound 2a, one the most potent G9a inhibitor identified, was endowed with >130-fold selectivity over GLP and excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c16f1d726f60b59e9a6c51d4c6d75e5
https://pubmed.ncbi.nlm.nih.gov/35718104
https://pubmed.ncbi.nlm.nih.gov/35718104
Autor:
Michael Prime, Samantha Green, Celia Dominguez, Edith Monteagudo, Malcolm Taylor, Akihiro Takano, Longbin Liu, Adrian Kotey, Wayne Thomas, Zhisheng Jia, Anthony P Dickie, Catherine Greenaway, Samuel Coe, Miklós Tóth, John Wityak, Vinod Khetarpal, Sergio Menta, Simone Esposito, Katarina Vanräs, Andreas Ebneth, John E. Mangette, Ian Wigginton, Todd Herbst, Peter Johnson, Sabine Schaertl, Vladimir Stepanov, Jonathan Bard, Sebastien Galan, Elise Gadouleau, Randall Davis, Christopher John Brown, Frank Herrmann, Richard W Marston, Darshan Gunvant Vaidya, Laura Orsatti, Xuemei Chen, Martina Nibbio, Manuela Heßmann, Joanne Sproston, Matthew R Mills, Ignacio Munoz-Sanjuan, Daniel Clark-Frew, Derek Alexander Weddell, Ladislav Mrzljak, Christoph Scheich, Xinjie Gai, Christer Halldin, Sangram Nag, Lee Matthew, Patricia Miranda-Azpiazu, Paul Giles, Thomas Krulle, Alexander Kiselyov, Marie Svedberg, Sarah Hayes
Publikováno v:
Journal of medicinal chemistry. 63(15)
Mutant huntingtin (mHTT) protein carrying the elongated N-terminal polyglutamine (polyQ) tract misfolds and forms protein aggregates characteristic of Huntington's disease (HD) pathology. A high-affinity ligand specific for mHTT aggregates could serv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bbb7331f2e0517d6d294883abdcc6f
https://pubmed.ncbi.nlm.nih.gov/32662649
https://pubmed.ncbi.nlm.nih.gov/32662649
Autor:
Martina Nibbio, Roberto Speziale, Simone Esposito, Laura Orsatti, Edith Monteagudo, Maria Veneziano, Fabio Bonelli, Elena Bracacel
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 118
This work describes a simple, sensitive and rapid liquid chromatography-high resolution mass spectrometry method for the quantitation of perhexiline and the simultaneous detection of perhexiline metabolites in C57bl/6 mice plasma. Only 5 μL of plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533cee6b005931b1ccee7c7d68bcca01
https://pubmed.ncbi.nlm.nih.gov/26517851
https://pubmed.ncbi.nlm.nih.gov/26517851
Autor:
Matteo Andreini, Annette Bakker, Martina Nibbio, Federica Mennillo, Alessandra De Robertis, Elisa Turlizzi, Tiziana Benicchi, Ugo Zanelli, Matteo Magnani, Maurizio Varrone, Marco Rossi, Federico Cappelli, Nicola P. Caradonna, Carmela Pratelli, Patrizia Tunici, Arianna Nencini, Silvia Valensin, Joanna Quinn, Massimiliano Salerno
Publikováno v:
European journal of medicinal chemistry. 95
Wnt signaling pathway plays a critical role in numerous cellular processes, including tumor initiation, proliferation, invasion/infiltration, metastasis formation and resistance to chemotherapy. In a drug discovery project aimed at the identification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81949a8a942e1517a5eeb788d199e14
https://pubmed.ncbi.nlm.nih.gov/25847770
https://pubmed.ncbi.nlm.nih.gov/25847770
Autor:
Martina Nibbio, Roberto Angelini, Massenzio Fornasier, Paolo Perfetti, Marta Bellini, Claus A. Andersen
Publikováno v:
Journal of neuroscience methods. 232
Background For CNS drugs, brain disposition is of critical importance during drug discovery. In vitro methods are used early followed by more predictive in vivo methods later on in the drug discovery process. Current in vivo methods are costly, have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b4b5191272e469bc1ac41e2fe0ce9e
https://pubmed.ncbi.nlm.nih.gov/24880048
https://pubmed.ncbi.nlm.nih.gov/24880048