Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Martina Miteva"'
Autor:
Meredith A. Jackson, Todd D. Giorgio, Thomas A. Werfel, Kellye C. Kirkbride, Martina Miteva, Taylor E. Kavanaugh, Craig L. Duvall
Publikováno v:
Journal of Controlled Release. 255:12-26
A rationally-designed library of ternary siRNA polyplexes was developed and screened for gene silencing efficacy in vitro and in vivo with the goal of overcoming both cell-level and systemic delivery barriers. [2-(dimethylamino)ethyl methacrylate] (D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a133f0b22ea4c5b430e1f3a85a0ec46
https://doi.org/10.1016/j.jconrel.2017.03.389
https://doi.org/10.1016/j.jconrel.2017.03.389
Autor:
Corban Swain, Kameron V. Kilchrist, Craig L. Duvall, Thomas A. Werfel, Brian C. Evans, Christopher E. Nelson, Martina Miteva
Publikováno v:
Journal of Biomedical Materials Research Part A. 104:917-927
Hydrolytically degrading nano-polyplexes (HDG-NPs) that reverse charge through conversion of tertiary amines to carboxylic acids were investigated to improve intracellular un-packaging of siRNA and target gene silencing compared to a non-degradable a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19f26044c10c12e131db96aec892e12
https://doi.org/10.1002/jbm.a.35629
https://doi.org/10.1002/jbm.a.35629
Publikováno v:
Journal of Biomedical Materials Research Part A. 103:3107-3116
Clinical translation of siRNA therapeutics has been limited by the inability to effectively overcome the rigorous delivery barriers associated with intracellular-acting biologics. Here, to address both potency and longevity of siRNA gene silencing, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e567e8503b40cf3c20512ac467753cde
https://doi.org/10.1002/jbm.a.35413
https://doi.org/10.1002/jbm.a.35413
Autor:
Samantha M. Sarett, Craig L. Duvall, Kelsey R. Beavers, Christopher E. Nelson, Martina Miteva
Publikováno v:
Nanomedicine. 8:329-332
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c153cb6f6dd7146414036dada0186ac6
https://doi.org/10.2217/nnm.13.9
https://doi.org/10.2217/nnm.13.9
Autor:
Kellye C. Kirkbride, Martina Miteva, Christopher E. Nelson, Ming J. Cheng, Craig L. Duvall, Mukesh Kumar Gupta, Todd D. Giorgio, Hongmei Li, Elaine M. Simpson
Publikováno v:
Biomacromolecules
A dual-targeted siRNA nanocarrier has been synthesized and validated that is selectively activated in environments where there is colocalization of two breast cancer hallmarks, elevated matrix metalloproteinase (MMP) activity and folate receptor over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8966378f99c396658e81ec65f761bae1
https://pubmed.ncbi.nlm.nih.gov/25414930
https://pubmed.ncbi.nlm.nih.gov/25414930
Autor:
Martina Miteva, Thomas A. Werfel, Todd D. Giorgio, Hongmei Li, Craig L. Duvall, Shann S. Yu, Christopher E. Nelson
Publikováno v:
Advanced functional materials. 23(24)
Small interfering RNA (siRNA) has significant potential to evolve into a new class of pharmaceutical inhibitors, but technologies that enable robust, tissue-specific intracellular delivery must be developed before effective clinical translation can b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceeb9f288ea7d441988e7f7b43718c20
https://pubmed.ncbi.nlm.nih.gov/25214828
https://pubmed.ncbi.nlm.nih.gov/25214828
Publikováno v:
Journal of biomedical materials research. Part A. 103(9)
Clinical translation of siRNA therapeutics has been limited by the inability to effectively overcome the rigorous delivery barriers associated with intracellular-acting biologics. Here, to address both potency and longevity of siRNA gene silencing, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::94afa6ac9ea907a632d15f33f25b4910
https://pubmed.ncbi.nlm.nih.gov/25641816
https://pubmed.ncbi.nlm.nih.gov/25641816
Autor:
Craig L. Duvall, Todd D. Giorgio, Mukesh Kumar Gupta, Hongmei Li, Christopher E. Nelson, Kellye C. Kirkbride, Thomas A. Werfel, Kameron V. Kilchrist, Martina Miteva
Publikováno v:
Biomaterials. 38
A series of endosomolytic mixed micelles was synthesized from two diblock polymers, poly[ethylene glycol-b-(dimethylaminoethyl methacrylate-co-propylacrylic acid-co-butyl methacrylate)] (PEG-b-pDPB) and poly[dimethylaminoethyl methacrylate-b-(dimethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2a88151ef74da304ad5f4e48f3041d
https://pubmed.ncbi.nlm.nih.gov/25453977
https://pubmed.ncbi.nlm.nih.gov/25453977
RNA interference (RNAi) drugs have significant therapeutic potential but delivery systems with appropriate efficacy and toxicity profiles are still needed. Here, we describe a neutral, ampholytic polymeric delivery system based on conjugatable dibloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce49254b11df5c9a5c0e4acd079eeaf
https://europepmc.org/articles/PMC3625707/
https://europepmc.org/articles/PMC3625707/
Publikováno v:
ITiCSE
ProgrammingLand is an online system for delivering content to introductory computer science courses as a substitute for a conventional textbook. Because the system has a large number of exhibits, sometimes students were not finding the material neede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960b1e66bcc45a4cdae9ff984a35a35d
https://doi.org/10.1145/1140124.1140174
https://doi.org/10.1145/1140124.1140174