Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Martina Malnar"'
Autor:
Mirsada Causevic, Kristina Dominko, Martina Malnar, Lea Vidatic, Stjepko Cermak, Martina Pigoni, Peer-Hendrik Kuhn, Alessio Colombo, Daniel Havas, Stefanie Flunkert, Jessica McDonald, Jenny M Gunnersen, Birgit Hutter-Paier, Sabina Tahirovic, Manfred Windisch, Dimitri Krainc, Stefan F Lichtenthaler, Silva Hecimovic
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200344 (2018)
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer's disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase (
Externí odkaz:
https://doaj.org/article/1789a778f74f4473b3cee534b11a03e1
Publikováno v:
Neurobiology of Disease, Vol 72, Iss , Pp 37-47 (2014)
Alzheimer's disease (AD) and Niemann–Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic
Externí odkaz:
https://doaj.org/article/c76fe41610c94ab79b4549b4ffdd5377
Autor:
Bjoern von Einem, Petra Weber, Michael Wagner, Martina Malnar, Marko Kosicek, Silva Hecimovic, Christine A. F. von Arnim, Herbert Schneckenburger
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 12, Pp 15801-15812 (2012)
Förster resonance energy transfer (FRET) -based techniques have recently been applied to study the interactions between β-site APP-cleaving enzyme-GFP (BACE1-GFP) and amyloid precursor protein-mRFP (APP-mRFP) in U373 glioblastoma cells. In this con
Externí odkaz:
https://doaj.org/article/4514826677c544ceb9866a6349144f07
Autor:
Marijeta Kralj, Marijana Đaković, Mario Vazdar, Tonko Dražić, Ivan Habus, Silva Hećimović, Martina Malnar, Ana-Matea Mikecin, Katarina Vazdar
Publikováno v:
Tetrahedron. 71:9202-9215
A facile and efficient transformation of amino-β-lactam guanidines to 2-aminoimidazolones is described. The base-promoted transformation proceeds in two steps, with the rearrangement of four-membered β-lactam ring to five-membered imidazolone and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55c991a712ff86be22c886eab9a0dee
https://doi.org/10.1016/j.tet.2015.10.048
https://doi.org/10.1016/j.tet.2015.10.048
Autor:
Kristina Dominko, Birgit Hutter-Paier, Stefan F. Lichtenthaler, Stjepko Cermak, Peer-Hendrik Kuhn, Dimitri Krainc, Martina Pigoni, Daniel Havas, Jessica McDonald, Mirsada Causevic, Alessio Colombo, Silva Hećimović, Manfred Windisch, Sabina Tahirovic, Stefanie Flunkert, Lea Vidatic, Martina Malnar, Jenny M. Gunnersen
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200344 (2018)
PLoS One
PLOS ONE 13(7), e0200344 (2018). doi:10.1371/journal.pone.0200344
PLoS ONE
PLoS One
PLOS ONE 13(7), e0200344 (2018). doi:10.1371/journal.pone.0200344
PLoS ONE
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer’s disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2df86dd999ca75b47b30c346042316
http://europepmc.org/articles/PMC6034874?pdf=render
http://europepmc.org/articles/PMC6034874?pdf=render
Autor:
Jasminka Stefulj, Cornelia Schweinzer, Monika Scholler, Maja Perić, Marko Kosicek, Jelena Zivkovic, Martina Malnar, Silva Hećimović, Ute Panzenboeck
Publikováno v:
Current Pharmaceutical Biotechnology. 14:582-593
Niemann-Pick type C disease (NPC) is an inherited disorder mainly caused by loss-of-function mutations in the NPC1 gene, that lead to intracellular cholesterol accumulation and disturbed cholesterol homeostasis. Similarly to Alzheimer's disease (AD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6acec2f6ab39b2ea87d04c552ecc7a2
https://doi.org/10.2174/138920101131400224
https://doi.org/10.2174/138920101131400224
Autor:
Katarina Vazdar, Ivan Habus, Martina Malnar, Silva Hećimović, Mario Vazdar, Ana-Matea Mikecin, Tonko Drazic, Marijana Dakovic, Marijeta Kralj
Publikováno v:
ChemInform. 47
An interesting conversion of amino-β-lactam guanidines (III) to imidazolones of type (IV) and (V) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb71eefd9e10a7a91526a9676067cfa0
https://doi.org/10.1002/chin.201611151
https://doi.org/10.1002/chin.201611151
Autor:
Maria Blomqvist, Caroline A. Hastings, Erik Portelius, Ulf Andreasson, Johan Gobom, Marko Kosicek, Niklas Mattsson, Mikael K. Gustavsson, Maria Olsson, Silva Hećimović, Kaj Blennow, Charles H. Vite, Martina Malnar, Gunnar Brinkmalm, Henrik Zetterberg, Jan-Eric Månsson
Publikováno v:
Metabolic Brain Disease. 27:573-585
Niemann-Pick type C (NPC) is a progressive neurodegenerative lysosomal disease with altered cellular lipid trafficking. The metabolism of amyloid-β (Aβ) - previously mainly studied in Alzheimer's disease - has been suggested to be altered in NPC. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b7408a280a925b7a91fdc1ce2ee539
https://doi.org/10.1007/s11011-012-9332-8
https://doi.org/10.1007/s11011-012-9332-8
Publikováno v:
Translational Neuroscience. 2:241-245
Mutations in human dysferlin (DYSF) gene cause both limb girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy (MM), also named dysferlinopathy. They are autosomal recessive muscular dystrophies characterized by degeneration and weakness of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cc05d8f0fe7b363c245480f31b8aef
https://doi.org/10.2478/s13380-011-0028-z
https://doi.org/10.2478/s13380-011-0028-z
Autor:
Tonko, Dražić, Vinay, Sachdev, Christina, Leopold, Jay V, Patankar, Martina, Malnar, Silva, Hećimović, Sanja, Levak-Frank, Ivan, Habuš, Dagmar, Kratky
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The goal of this work was to synthesize new amide ezetimibe analogs from trans-3-amino-
The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The goal of this work was to synthesize new amide ezetimibe analogs from trans-3-amino-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d8fc7c8aa45ac9e653fb485f4d9b5eb
https://pubmed.ncbi.nlm.nih.gov/25882530
https://pubmed.ncbi.nlm.nih.gov/25882530