Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Martina Lukasova"'
Publikováno v:
Ann Transl Med
Primary sclerosing cholangitis (PSC) is a rare progressive cholangitis resulting in cirrhosis and cholangiocellular carcinoma. The pathogenesis is unclear and an effective medical therapy is not available. It is highly associated to ulcerative coliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e62ccd5410de03f7533ee80dccc1fe
https://pubmed.ncbi.nlm.nih.gov/33987436
https://pubmed.ncbi.nlm.nih.gov/33987436
Autor:
Stefan Offermanns, Angela Wirth, Seiko Takefuji, Mikito Takefuji, Thomas Braun, Martina Lukasova, Thomas Boettger, Till F. Althoff, Nina Wettschureck
Publikováno v:
Circulation. 126:1972-1982
Background— Cardiac remodeling in response to pressure or volume overload plays an important role in the pathogenesis of heart failure. Various mechanisms have been suggested to translate mechanical stress into structural changes, one of them being
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a11a9b4939ad304e0e957059e6d08a
https://doi.org/10.1161/circulationaha.112.109256
https://doi.org/10.1161/circulationaha.112.109256
Publikováno v:
Journal of Clinical Investigation. 121:1163-1173
Nicotinic acid (niacin) is a drug used to reduce the progression of atherosclerosis. Its antiatherosclerotic activity is believed to result from lipid-modifying effects, including its ability to decrease LDL cholesterol and increase HDL cholesterol l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602a965b72166cbf027566099f0041ba
https://doi.org/10.1172/jci41651
https://doi.org/10.1172/jci41651
Autor:
Günther Schütz, Björn Lemmer, Stefan Offermanns, Christiane Maser-Gluth, Zoltán Benyó, Petra Örsy, Stefan Gorbey, Martina Lukasova, J. Silvio Gutkind, Nina Wettschureck, Erich Greiner, Béla Horváth, Barbara Leutgeb, Angela Wirth
Publikováno v:
Nature Medicine. 14:64-68
The tone of vascular smooth muscle cells is a primary determinant of the total peripheral vascular resistance and hence the arterial blood pressure. Most forms of hypertension ultimately result from an increased vascular tone that leads to an elevate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0b04131a93f4a7dc05c4d936d51bc8
https://doi.org/10.1038/nm1666
https://doi.org/10.1038/nm1666
Publikováno v:
British Journal of Pharmacology. 148:825-832
1 The potential cardioprotective effect of ACE inhibitors has been attributed to the inhibition of bradykinin degradation. Recent data in rats documented a kallidin-like peptide, which mimics the cardioprotective effect of ischaemic preconditioning.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2faf3d100e3070fa43b60a94754ab623
https://doi.org/10.1038/sj.bjp.0706799
https://doi.org/10.1038/sj.bjp.0706799
Publikováno v:
British Journal of Pharmacology. 146:958-963
The kallikrein–kinin system is subdivided into the plasma and tissue–kallikrein–kinin system, with bradykinin (BK) and kallidin (KAL) (Lys0-bradykinin) as functional peptides. This occurs in both humans and other mammals. Both peptides are rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2200b60553f3eebc44b7e964a19e8abb
https://doi.org/10.1038/sj.bjp.0706409
https://doi.org/10.1038/sj.bjp.0706409
Publikováno v:
British Journal of Pharmacology. 146:952-957
Bradykinin is thought to play a major role among the endogenous cardioprotective candidates of ischaemic preconditioning (IPC). Little attention has been paid to the fact that in the tissue kallidin (KAL), rather than bradykinin might be the physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::179042afb4bfb31daa4eea65f0e2d99d
https://doi.org/10.1038/sj.bjp.0706402
https://doi.org/10.1038/sj.bjp.0706402
Regulatory effects of salt diet on renal renin–angiotensin–aldosterone, and kallikrein–kinin systems
Publikováno v:
International Immunopharmacology. 2:1975-1980
The interaction of the renin-angiotensin-aldosterone system (RAAS) and the kallikrein-kinin system (KKS) was investigated in rats fed on a low, normal, and high-salt diet for 2 weeks. At the beginning of the second week, either a B2-receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f56129ac561535af6671bb4a8d0461
https://doi.org/10.1016/s1567-5769(02)00163-7
https://doi.org/10.1016/s1567-5769(02)00163-7
Autor:
Björn E. Clausen, Andreas Gille, Kashan Ahmed, Sabrina Zwykiel, Stefan Offermanns, Martina Lukasova, Angela Wirth, Sorin Tunaru, Julien Hanson
Publikováno v:
Journal of Clinical Investigation, 120(8), 2910-2919. The American Society for Clinical Investigation
Journal of clinical investigation, 120(8), 2910-2919. The American Society for Clinical Investigation
Europe PubMed Central
Journal of clinical investigation, 120(8), 2910-2919. The American Society for Clinical Investigation
Europe PubMed Central
The antidyslipidemic drug nicotinic acid and the antipsoriatic drug monomethyl fumarate induce cutaneous flushing through activation of G protein-coupled receptor 109A (GPR109A). Flushing is a troublesome side effect of nicotinic acid, but may be a d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dac356974cfbfa126e385151e08c60
https://pure.eur.nl/en/publications/22d477e5-4a77-4ccf-b9ca-9a34c3c6f232
https://pure.eur.nl/en/publications/22d477e5-4a77-4ccf-b9ca-9a34c3c6f232
Autor:
Youyan Zhang, Stefan Offermanns, Martina Lukasova, Guoqing Cao, Eric P. Plaisance, Robert L. Judd
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 296(3)
Niacin (nicotinic acid) has recently been shown to increase serum adiponectin concentrations in men with the metabolic syndrome. However, little is known about the mechanism(s) by which niacin regulates the intracellular trafficking and secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd1b0107ebd7b4719ec931acf20e68e
https://pubmed.ncbi.nlm.nih.gov/19141678
https://pubmed.ncbi.nlm.nih.gov/19141678