Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Martina Lahmann"'
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1869 (2023)
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://doaj.org/article/6e8ca26b7c334320af200daf96523567
Autor:
Eva Ramos-Morales, Gabriel de la Fuente, Robert J Nash, Radek Braganca, Stephane Duval, Marc E Bouillon, Martina Lahmann, C Jamie Newbold
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184517 (2017)
The antiprotozoal effect of saponins is transitory, as when saponins are deglycosylated to sapogenins by rumen microorganisms they become inactive. We hypothesised that the combination of saponins with glycosidase-inhibiting iminosugars might potenti
Externí odkaz:
https://doaj.org/article/039e41b0b8ac41a7ab1b2ea87e40d353
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 6, Iss 1, Pp 704-708 (2010)
Background: In bacteria with truncated lipopolysaccharide structures, i.e., lacking the O-antigen polysaccharide part, core structures are exposed to the immune system upon infection and thus their use as carbohydrate surface antigens in glycoconjuga
Externí odkaz:
https://doaj.org/article/6494bb44a29f4a5192ffd98fa952ab48
Autor:
Josef Houser, Jan Komarek, Nikola Kostlanova, Gianluca Cioci, Annabelle Varrot, Sheena C Kerr, Martina Lahmann, Viviane Balloy, John V Fahy, Michel Chignard, Anne Imberty, Michaela Wimmerova
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83077 (2013)
Aspergillus fumigatus is an important allergen and opportunistic pathogen. Similarly to many other pathogens, it is able to produce lectins that may be involved in the host-pathogen interaction. We focused on the lectin AFL, which was prepared in rec
Externí odkaz:
https://doaj.org/article/e8c4933f28ba41b996355d44554684c0
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Hoffmann, Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F.
Publikováno v:
Pharmaceutics; Volume 15; Issue 7; Pages: 1869
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::e26071b6395e29f0a6a5d909ce45b6de
Autor:
Mark Reihill, Viviane Fournière, Aisling Ní Cheallaigh, Johan Olofsson Edlund, Gavin John Miller, Thomas Borén, Martina Lahmann, Stefan Oscarson
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany).
Infecting the stomach of almost 50 % of people, Helicobacter pylori is a causative agent of gastritis, peptic ulcers and stomach cancers. Interactions between bacterial membrane-bound lectin, Blood group Antigen Binding Adhesin (BabA), and human bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb19363bdd82d3cb6bdcf25389b945b
https://pubmed.ncbi.nlm.nih.gov/36562295
https://pubmed.ncbi.nlm.nih.gov/36562295
Autor:
Laura Bischoff, Michelle Buri, Elizabeth J. Wilkinson, Katia Bertocco, Marc E. Bouillon, Martina Lahmann, Lucy R. Davies
Publikováno v:
European Journal of Organic Chemistry. 2020:7470-7473
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::149eb70cb5a40663467a05b497a7e21d
https://doi.org/10.1002/ejoc.202001317
https://doi.org/10.1002/ejoc.202001317
Autor:
Jack H Owen, Martina Lahmann, Carla C Briggs, Liam A Natrass, Rhodri Mir Williams, Paul W. Denny, Mark S. Baird, Angelos Loukaidis, Deiniol Pritchard, Charles F Cranston, Joseph Beckett, Elizabeth J. Wilkinson, Orlagh Anderson, Marc E. Bouillon
Publikováno v:
RSC Medicinal Chemistry
RSC medicinal chemistry, 2020, Vol.11(7), pp.833-842 [Peer Reviewed Journal]
RSC medicinal chemistry, 2020, Vol.11(7), pp.833-842 [Peer Reviewed Journal]
Hit anti-leishmanial saponin structures selected following primary and secondary screening.
Leishmaniasis is a neglected tropical disease caused by insect-vector borne protozoan parasites of the, Leishmania species. Whilst infection threatens an
Leishmaniasis is a neglected tropical disease caused by insect-vector borne protozoan parasites of the, Leishmania species. Whilst infection threatens an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f735c0b5afb3ff91d20a13e241ab2
http://europepmc.org/articles/PMC7651632
http://europepmc.org/articles/PMC7651632
Publikováno v:
Organic & Biomolecular Chemistry. 18:4452-4458
While 13C-labelled proteins are common tools in NMR studies, lack of access to 13C-labelled carbohydrate structures has restricted their use. L-Fucose is involved in a wide range of physiological and pathophysiological processes in mammalian organism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98ad0a6168e8b8691cbf7033699d8e8c
https://doi.org/10.1039/d0ob00426j
https://doi.org/10.1039/d0ob00426j
Autor:
Anand Chakroborty, Deiniol Pritchard, Marc E. Bouillon, Anna Cervi, Alan Cookson, Charlotte Wild, Caroline Fenn, Joseph Payne, Peter Holdsworth, Colin Capner, Jenna O’Neill, Gilda Padalino, Josephine Forde-Thomas, Sandeep Gupta, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Veterinary Parasitology. 309:109766
Control of liver fluke infections remains a significant challenge in the livestock sector due to widespread distribution of drug resistant parasite populations. In particular, increasing prevalence and economic losses due to infection with Fasciola h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0859b364368ea30a22b08036ba7ef6b
https://doi.org/10.1016/j.vetpar.2022.109766
https://doi.org/10.1016/j.vetpar.2022.109766