Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Martina Kinzig‐Schippers"'
Autor:
Martina Kinzig-Schippers, Steven Fikes, Arnold Louie, Weiguo Liu, George L. Drusano, Brian VanScoy, David L. Brown, Fritz Sörgel, A. Eichas, K. Files, Henry S. Heine
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:822-830
Yersinia pestis , the causative agent of bubonic, septicemic, and pneumonic plague, is classified as a CDC category A bioterrorism pathogen. Streptomycin and doxycycline are the “gold standards” for the treatment of plague. However, streptomycin
Autor:
Friedrich Vogel, Jürgen B. Bulitta, Thomas P. Lodise, Markus Hinder, George L. Drusano, Ulrich Loos, Martina Kinzig-Schippers, Fritz Sörgel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:1945-1951
Cefditoren is a broad-spectrum, oral cephalosporin that is highly active against clinically relevant respiratory tract pathogens, including multidrug-resistantStreptococcus pneumoniae. This study described its pharmacodynamic profile in plasma and ep
Autor:
Arnold Louie, Lawrence J. Sullivan, Jennifer Bassett, Henry S. Heine, Fritz Sörgel, Lynda Miller, George L. Drusano, Martina Kinzig-Schippers
Publikováno v:
The Journal of Infectious Diseases. 196:782-787
Introduction. Intentional release of Yersinia pestis will likely be propagated by aerosol exposure. We explored the effects of neutropenia on the outcome of doxycycline and gentamicin therapy. Methods. Female BALB/c mice were exposed to 20 LD 50 of Y
Autor:
Samir G. Sakka, Martina Kinzig-Schippers, George L. Drusano, Fritz Sörgel, Jürgen B. Bulitta, Wolfgang Pfister, Anna K. Glauner
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:3304-3310
Beta-lactams are regularly administered in intermittent short-term infusions. The percentage of the dosing interval during which free drug concentrations exceed the MIC ( fT >MIC ) is the measure of drug exposure that best correlates with clinical ou
Autor:
Wolfgang Weidner, Kurt G. Naber, Fritz Sörgel, Florian M.E. Wagenlehner, Martina Kinzig-Schippers
Publikováno v:
International Journal of Antimicrobial Agents. 28:551-559
In a randomised crossover study, 14 volunteers received a single oral dose of 500 mg levofloxacin or 500 mg ciprofloxacin in order to assess plasma concentrations by high-pressure liquid chromatography (up to 24 h), urinary excretion and urinary bact
Autor:
Kurt G. Naber, Christine Wagenlehner, Fritz Sörgel, Florian M.E. Wagenlehner, Martina Kinzig-Schippers, Uwe Tischmeyer, Axel Dalhoff
Publikováno v:
International Journal of Antimicrobial Agents. 27:7-14
The new extended-release formulation of ciprofloxacin (ciprofloxacin XR) was designed for once-daily administration in the treatment of urinary tract infection (UTI). The aim of this study was to compare concentrations in plasma, urinary excretion (U
Autor:
George L. Drusano, Martina Kinzig-Schippers, Jürgen B. Bulitta, Kurt G. Naber, Wolfgang A. Krueger, Cornelia B. Landersdorfer, Fritz Sörgel, Ulrike Holzgrabe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:1881-1889
Meropenem is a broad-spectrum carbapenem antibacterial agent. In order to optimize levels in plasma relative to the MICs, the ideal dose level and dosage regimen need to be determined. The pharmacokinetics of meropenem were studied in two groups, eac
Autor:
Alexander Jetter, Martina Kinzig-Schippers, Verena Jakob, Uwe Fuhr, Bernhard Scheidel, Ingolf Cascorbi, Oxana Doroshyenko, Michael Rodamer, Fritz Sörgel, Dorota Tomalik-Scharte
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:1733-1738
Isoniazid is metabolized by the genetically polymorphic arylamine N -acetyltransferase type 2 (NAT2). A greater number of high-activity alleles are related to increased acetylation capacity and in some reports to low efficacy and toxicity of isoniazi
Autor:
Andreas Skott, Alexander Jetter, Uwe Fuhr, Andreas Lazar, Verena Jakob, Fritz Sörgel, Dirk Kasel, Jürgen Brockmöller, Julia Kirchheiner, Wafaâ Jabrane, Ursula Hering, Dorota Tomalik-Scharte, Michael Rodamer, Monika Walchner-Bonjean, Martina Kinzig-Schippers
Publikováno v:
European Journal of Clinical Pharmacology. 60:165-171
The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived parameter based on a single plasma or urine concentration
Autor:
Monika Walchner-Bonjean, Alexander Jetter, Jürgen B. Bulitta, Martina Kinzig-Schippers, F. Sörgel, Uwe Fuhr, Philipp Schreiner, Ursula Hering
Publikováno v:
Clinical Pharmacology & Therapeutics. 71:21-29
Background And Objectives Because of extensive first-pass metabolism, oral bioavailability of sildenafil reaches only 40%. Formation of the primary metabolite, N-desmethylsildenafil, is mainly mediated by the cytochrome P450 enzyme CYP3A4. In this st