Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein Synthesis

Autor: Ekaterina Eremenko, Lior Onn, Shai Kaluski, Thomas Arendt, Debra Toiber, Martina K. Brückner, Monica Einav, Uwe Ueberham, Miguel Portillo, Daniel Stein, Zeev Slobodnik

Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee3d9894f875469e06ca354859dabb1
https://doi.org/10.1101/2020.09.01.276782

The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation.

Autor: Jens T Stieler, Torsten Bullmann, Franziska Kohl, Øivind Tøien, Martina K Brückner, Wolfgang Härtig, Brian M Barnes, Thomas Arendt

Publikováno v: PLoS ONE, Vol 6, Iss 1, p e14530 (2011)

Abnormal phosphorylation and aggregation of tau protein are hallmarks of a variety of neurological disorders, including Alzheimer's disease (AD). Increased tau phosphorylation is assumed to represent an early event in pathogenesis and a pivotal aspec

Externí odkaz: https://doaj.org/article/26cba18f14b1415c811a1cb3444c764b

SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

Autor: Daniel Stein, Alfredo Garcia-Venzor, Monica Einav, Zeev Slobodnik, Debra Toiber, Uwe Ueberham, Shai Kaluski, Adam Zaretsky, Miguel Portillo, Martina K. Brückner, Ekaterina Eremenko, Lior Onn, Thomas Arendt

Publikováno v: Cell Reports. 35:109035

Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegeneration. Here, we show that Tau hyper-acetylation at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734f1f62c0c98ed888b1fb8339b727ec
https://doi.org/10.1016/j.celrep.2021.109035

A Cytomic Approach Towards Genomic Individuality of Neurons

Autor: Markus Morawski, Attila Tárnok, Uwe Ueberham, Martina K. Brückner, Birgit Belter, Thomas Arendt

Publikováno v: Frade, Jose Maria, Gage, Fred H.: A Cytomic Approach Towards Genomic Individuality of Neurons, Paris: Springer, 2017, 978-1-4939-7279-1, 81-106
Neuromethods ISBN: 9781493972791

Here, we describe an approach for the DNA quantification of single cells in brain slices based on image cytometry (IC) that allows mapping the distribution of neurons with DNA content variation (DCV) in the context of preserved tissue architecture. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a14b9ecdebeb341a0a6c125af9869f9
https://www.hzdr.de/publications/Publ-26879-1

Changes in neuronal DNA content variation in the human brain during aging

Autor: Markus Morawski, Attila Tárnok, Thomas Arendt, Hans-Georg Fischer, Martina K. Brückner, Anja Mittag

Publikováno v: Aging Cell. 11:628-633

The human brain has been proposed to represent a genetic mosaic, containing a small but constant number of neurons with an amount of DNA exceeding the diploid level that appear to be generated through various chromosome segregation defects initially.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3c51148744adfc089b0b1bae403cbb7
https://doi.org/10.1111/j.1474-9726.2012.00826.x