The alternative coproporphyrinogen III oxidase (CgoN) catalyzes the oxygen-independent conversion of coproporphyrinogen III into coproporphyrin III

Autor: Toni Mingers, Stefan Barthels, Violetta Mass, José Manuel Borrero-de Acuña, Rebekka Biedendieck, Ana Cooke, Tamara A. Dailey, Svetlana Gerdes, Wulf Blankenfeldt, Harry A. Dailey, Martin J. Warren, Martina Jahn, Dieter Jahn

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Nature utilizes three distinct pathways to synthesize the essential enzyme cofactor heme. The coproporphyrin III-dependent pathway, predominantly present in Bacillaceae, employs an oxygen-dependent coproporphyrinogen III oxidase (CgoX) that converts

Externí odkaz: https://doaj.org/article/c08797d53e68449fa3988cd244d0c552

Comprehensive comparison of in silico MS/MS fragmentation tools of the CASMI contest: database boosting is needed to achieve 93% accuracy

Autor: Ivana Blaženović, Tobias Kind, Hrvoje Torbašinović, Slobodan Obrenović, Sajjan S. Mehta, Hiroshi Tsugawa, Tobias Wermuth, Nicolas Schauer, Martina Jahn, Rebekka Biedendieck, Dieter Jahn, Oliver Fiehn

Publikováno v: Journal of Cheminformatics, Vol 9, Iss 1, Pp 1-12 (2017)

Abstract In mass spectrometry-based untargeted metabolomics, rarely more than 30% of the compounds are identified. Without the true identity of these molecules it is impossible to draw conclusions about the biological mechanisms, pathway relationship

Externí odkaz: https://doaj.org/article/5dc498693f11454097890d3dedafa18d

Radical SAM Enzymes Involved in Tetrapyrrole Biosynthesis and Insertion

Autor: Gunhild Layer, Martina Jahn, Jürgen Moser, Dieter Jahn

Publikováno v: ACS Bio & Med Chem Au. 2:196-204

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfcca72aa43236a26b2b3ea1e486bdd0
https://doi.org/10.1021/acsbiomedchemau.1c00061

Protein complex formation during denitrification by Pseudomonas aeruginosa

Autor: Kenneth N. Timmis, Martina Jahn, Dieter Jahn, José Manuel Borrero-de Acuña

Publikováno v: Microbial Biotechnology, Vol 10, Iss 6, Pp 1523-1534 (2017)

Summary The most efficient means of generating cellular energy is through aerobic respiration. Under anaerobic conditions, several prokaryotes can replace oxygen by nitrate as final electron acceptor. During denitrification, nitrate is reduced via ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e95b65c050d9f1c3eb33b056c8b2380
https://doaj.org/article/450a591941774f03be3b0a8e4520c444

The radical SAM protein HemW is a heme chaperone

Autor: Vera Haskamp, Simone Karrie, Stefan Barthels, François Alberge, Peter Schweyen, Kirstin Kleeberg, Martina Jahn, Axel Magalon, Eckhard Bill, Wolfgang Lubitz, Martin Bröring, Katrin Müller, Dieter Jahn, Toni Mingers

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2018, 293 (7), pp.2558-2572. ⟨10.1074/jbc.RA117.000229⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (7), pp.2558-2572. ⟨10.1074/jbc.RA117.000229⟩

International audience; Radical S-adenosylmethionine (SAM) enzymes exist in organisms from all kingdoms of life, and all of these proteins generate an adenosyl radical via the homolytic cleavage of the S–C(5’) bond of SAM. Of particular interest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380951a2d53ef3a0ad5c20d2acbadb7c
https://hal-amu.archives-ouvertes.fr/hal-01915476/document