Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Martina J. Sinnegger-Brauns"'
Autor:
Bohumila Jurkovicova-Tarabova, Joerg Striessnig, Eckhard Friauf, Martina J. Sinnegger-Brauns, Antonella Pirone, Désirée Griesemer
Publikováno v:
Journal of Neurophysiology. 108:365-379
Voltage-gated Ca2+ (Cav)1.3 α-subunits of high voltage-activated Ca2+ channels (HVACCs) are essential for Ca2+ influx and transmitter release in cochlear inner hair cells and therefore for signal transmission into the central auditory pathway. Their
Autor:
Jörg Striessnig, Martina J. Sinnegger-Brauns, Anja Scharinger, Simone B. Sartori, Andreas Lieb
Publikováno v:
Channels
A C-terminal modulatory domain (CTM) tightly regulates the biophysical properties of Ca(v)1.3 L-type Ca(2+) channels, in particular the voltage dependence of activation (V(0.5)) and Ca(2+) dependent inactivation (CDI). A functional CTM is present in
Functional Properties of a Newly Identified C-terminal Splice Variant of Cav1.3 L-type Ca2+ Channels
Autor:
Perrine Busquet, Alexandra Koschak, Gabriella Bock, Matteo E. Mangoni, Martina J. Sinnegger-Brauns, Joerg Striessnig, Wanchana Jangsangthong, Chiara Poggiani, Stefan Herzig, Mathias Gebhart, Simone B. Sartori, Anja Scharinger
Publikováno v:
The Journal of Biological Chemistry
An intramolecular interaction between a distal (DCRD) and a proximal regulatory domain (PCRD) within the C terminus of long Ca(v)1.3 L-type Ca(2+) channels (Ca(v)1.3(L)) is a major determinant of their voltage- and Ca(2+)-dependent gating kinetics. R
Autor:
Jutta Engel, Habib U. Khan, Gudrun Nürnberg, Matteo E. Mangoni, Hanno J. Bolz, Peter Nürnberg, Alexandra Koschak, Shahid Mahmood Baig, Martina J. Sinnegger-Brauns, Muhammad Farooq, Ilyas Ahmad, Jörg Striessnig, Mathias Gebhart, Claudia Dafinger, Amjad Ali, Niels Brandt, Andreas Lieb
Publikováno v:
Nature Neuroscience. 14:77-84
Deafness is genetically very heterogeneous and forms part of several syndromes. So far, delayed rectifier potassium channels have been linked to human deafness associated with prolongation of the QT interval on electrocardiograms and ventricular arrh
Autor:
Emilio Carbone, Andrea Marcantoni, Joerg Striessnig, Valentina Carabelli, Satyajit Mahapatra, David Vandael, Martina J. Sinnegger-Brauns
Publikováno v:
The Journal of Neuroscience. 30:491-504
We studied wild-type (WT) andCav1.3−/−mouse chromaffin cells (MCCs) with the aim to determine the isoform of L-type Ca2+channel (LTCC) and BK channels that underlie the pacemaker current controlling spontaneous firing. Most WT-MCCs (80%) were spo
Autor:
Gerald J. Obermair, Alexandra Koschak, Silja B Horak, Martina J. Sinnegger-Brauns, Claudia Wild, Katrin Schulze, Robert Tampé, Jörg Striessnig, Katrin Watschinger
Publikováno v:
Channels. 2:461-473
Depolarisation-induced Ca2+ influx into electrically excitable cells is determined by the density of voltage-gated Ca2+ channels at the cell surface. Surface expression is modulated by physiological stimuli as well as by drugs and can be altered unde
Autor:
Christoph Romanin, Jean-Charles Hoda, Alexandra Koschak, Mathias Gebhart, Martina J. Sinnegger-Brauns, Jutta Engel, Chiara Poggiani, Reinhard Fritsch, Jörg Striessnig, Anamika Singh
Publikováno v:
The Journal of Biological Chemistry
Low voltage activation of Ca(V)1.3 L-type Ca(2+) channels controls excitability in sensory cells and central neurons as well as sinoatrial node pacemaking. Ca(V)1.3-mediated pacemaking determines neuronal vulnerability of dopaminergic striatal neuron
Autor:
Jörg Striessnig, Gregory C. Amberg, Manuel F. Navedo, Ruth E. Westenbroek, Martina J. Sinnegger-Brauns, William A. Catterall, Luis Fernando Santana
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H1359-H1370
Ca2+sparklets are local elevations in intracellular Ca2+produced by the opening of a single or a cluster of L-type Ca2+channels. In arterial myocytes, Ca2+sparklets regulate local and global intracellular Ca2+. At present, the molecular identity of t
Autor:
Mordecai P. Blaustein, Jin Zhang, Martina J. Sinnegger-Brauns, Roberto Berra-Romani, Joerg Striessnig, Donald R. Matteson
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H415-H425
Ca2+ entry via L-type voltage-gated Ca2+ channels (LVGCs) is a key factor in generating myogenic tone (MT), as dihydropyridines (DHPs) and other LVGC blockers, including Mg2+, markedly reduce MT. Recent reports suggest, however, that elevated externa
Autor:
Irene G. Huber, Jörg Striessnig, Jean-Charles Hoda, Edwin Wappl-Kornherr, Doris Walter-Bastl, Martina J. Sinnegger-Brauns
Publikováno v:
Journal of Biological Chemistry. 279:55211-55217
Replacement of L-type Ca(2+) channel alpha(1) subunit residue Thr-1066 in segment IIIS5 by a tyrosine residue conserved in the corresponding positions of non-L-type Ca(2+) channels eliminates high dihydropyridine sensitivity through a steric mechanis