Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Martina Hruzova"'
Autor:
Anne E.J. Hillen, Martina Hruzova, Tanja Rothgangl, Marjolein Breur, Marianna Bugiani, Marjo S. van der Knaap, Gerald Schwank, Vivi M. Heine
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 17-25 (2022)
Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in subunits of eIF2B. At present, no curative treatment is available and patients often die at young age. Due to its monogenic nature, VWM is a promising candidate for the
Externí odkaz:
https://doaj.org/article/d51fbd1fddf8449885eaa46a547d3024
Autor:
Marlen Knobloch, Gregor-Alexander Pilz, Bart Ghesquière, Werner J. Kovacs, Thomas Wegleiter, Darcie L. Moore, Martina Hruzova, Nicola Zamboni, Peter Carmeliet, Sebastian Jessberger
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2144-2155 (2017)
Hippocampal neurogenesis is important for certain forms of cognition, and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic capacity of hippocampal neural stem/progenitor cells (NSPCs) depends on a balance between
Externí odkaz:
https://doaj.org/article/ec129b5d71fa47c29483cc78941eecb4
Publikováno v:
PLoS Biology, Vol 12, Iss 11, p e1001988 (2014)
The Wingless (Wg/Wnt) signaling pathway is essential for metazoan development, where it is central to tissue growth and cellular differentiation. Deregulated Wg pathway activation underlies severe developmental abnormalities, as well as carcinogenesi
Externí odkaz:
https://doaj.org/article/77a6bccc0bdd4832b06d2e7bf59c3ef5
Autor:
Tanja Rothgangl, Martina Hruzova, Ralph Gnannt, Nadja Aeberhard, Lucas Kissling, Hiu Man Grisch-Chan, Sven Klassa, Nicole Rimann, Kim F. Marquart, Eleonora Ioannidi, Anja Wolf, Christian Kupatt, Xaver Sidler, Johannes Häberle, Gerald Schwank, Beat Thöny
One challenge for liver-directed gene therapy is sufficient vector delivery to the target tissue while minimizing loss of the applied vector dose to other tissues. Infusion via peripheral veins is the least invasive approach; however, it results in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e29a86e47747a7ab0e74f492719f8e
https://doi.org/10.1101/2023.04.05.535660
https://doi.org/10.1101/2023.04.05.535660
Autor:
Andreas E. Moor, Nina Frey, Ying K. Tam, Denis V Victorov, Costanza Borrelli, Kevin Holden, Melissa K Dennis, Martin Jinek, Dominik Witzigmann, Rurika Oka, Susanne Kreutzer, Lukas Villiger, Gerald Schwank, Martina Hruzova, Lucas Kissling, Norbert Pardi, Daniela Lenggenhager, Markus Stoffel, Ruben van Boxtel, Zacharias Kontarakis, Beat Thöny, Sean C. Semple, Anastasia P. Kadina, John A. Walker, Johannes Häberle, Sabina Egli, Tanja Rothgangl, Noëlle Bakker, Martin Pacesa, Weihong Qi, Paulo J.C. Lin, Drew Weissman
Publikováno v:
Nature Biotechnology, 39 (8)
Nature Biotechnology
Nature biotechnology, 39(August 2021). Nature Publishing Group
Nature Biotechnology
Nature biotechnology, 39(August 2021). Nature Publishing Group
Most known pathogenic point mutations in humans are C center dot G to T center dot A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice an
Autor:
Iliana Mebert, Dominik Kollegger, Pawel Pelczar, Thomas Wegleiter, Adriano Molteni, Daniel Gonzalez-Bohorquez, Kilian Buthey, Sebastian Jessberger, Martina Hruzova, Muhammad Khadeesh bin Imtiaz, Andrin Abegg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
PNAS
PNAS
Significance Neural stem cells (NSCs) generate neurons and glia throughout life. Using global S-acylation profiling in NSCs, we identified BMPR1a, a main driver of embryonic and postnatal development to be S-acylated. We showed that BMPR1a is S-acyla
Autor:
Thomas Wegleiter, Martina Hruzova, Peter Carmeliet, Werner J. Kovacs, Nicola Zamboni, Bart Ghesquière, Darcie L. Moore, Sebastian Jessberger, Gregor-Alexander Pilz, Marlen Knobloch
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2144-2155 (2017)
Cell Reports
Cell Reports, vol. 20, no. 9, pp. 2144-2155
Cell Reports
Cell Reports, vol. 20, no. 9, pp. 2144-2155
Summary Hippocampal neurogenesis is important for certain forms of cognition, and failing neurogenesis has been implicated in neuropsychiatric diseases. The neurogenic capacity of hippocampal neural stem/progenitor cells (NSPCs) depends on a balance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f826a463e691400bc501a1d159a78bb3
https://lirias.kuleuven.be/handle/20.500.12942/686564
https://lirias.kuleuven.be/handle/20.500.12942/686564
Publikováno v:
Matters Select.
Throughout life neural stem/progenitor cells (NSPCs) produce new neurons in distinct regions of the mammalian brain, a process called adult neurogenesis. Hippocampal NSPCs undergo several developmental steps until they reach their final stage of full
Publikováno v:
PLoS Biology
PLoS Biology, Vol 12, Iss 11, p e1001988 (2014)
PLoS Biology, Vol 12, Iss 11, p e1001988 (2014)
This study uses an RNAi screen in Drosophila to identify a UBX protein, Armless, as a novel positive regulator of the important Wingless/Wnt signaling pathway, acting to stabilize Armadillo/?-Catenin by antagonizing its turnover.
The Wingless (W
The Wingless (W
Autor:
Michal Tatarkovič, Lucie Kocourková, Bohus Bunganic, Jan Csomor, Lucie Stovickova, Martina Hruzova, Miroslav Zavoral, Vladimír Setnička, Stepan Suchanek, Martin Laclav
Publikováno v:
Gastroenterology. 152:S840