Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Martina Hrabinová"'
Autor:
Michal Maryška, Lucie Svobodová, Wim Dehaen, Martina Hrabinová, Michaela Rumlová, Ondřej Soukup, Martin Kuchař
Publikováno v:
Pharmaceuticals, Vol 14, Iss 12, p 1291 (2021)
Kynurenic acid is a neuroprotective metabolite of tryptophan formed by kynurenine aminotransferase (KAT) catalyzed transformation of kynurenine. However, its high brain levels are associated with cognitive deficit and with the pathophysiology of schi
Externí odkaz:
https://doaj.org/article/35ee767a83e84b3da50a05098aaeabdc
Autor:
Abdullah Al Mamun, Filip Pidaný, Daniela Hulcová, Jana Maříková, Tomáš Kučera, Monika Schmidt, Maria Carmen Catapano, Martina Hrabinová, Daniel Jun, Lubica Múčková, Jiří Kuneš, Jiří Janoušek, Rudolf Andrýs, Lucie Nováková, Rozálie Peřinová, Negar Maafi, Ondřej Soukup, Jan Korábečný, Lucie Cahlíková
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8308 (2021)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the N-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence stron
Externí odkaz:
https://doaj.org/article/86aedb8c775643fd867b3536101e7ecd
Autor:
Abdullah Al Mamun, Jana Maříková, Daniela Hulcová, Jiří Janoušek, Marcela Šafratová, Lucie Nováková, Tomáš Kučera, Martina Hrabinová, Jiří Kuneš, Jan Korábečný, Lucie Cahlíková
Publikováno v:
Biomolecules, Vol 10, Iss 5, p 800 (2020)
Thirteen known (1–12 and 16) and three previously undescribed Amaryllidaceae alkaloids of belladine structural type, named carltonine A-C (13–15), were isolated from bulbs of Narcissus pseudonarcissus cv. Carlton (Amaryllidaceae) by standard chro
Externí odkaz:
https://doaj.org/article/f104316dbc2349da97bfd9cb7883a3aa
Autor:
Jakub Chlebek, Jan Korábečný, Rafael Doležal, Šárka Štěpánková, Daniel I. Pérez, Anna Hošťálková, Lubomír Opletal, Lucie Cahlíková, Kateřina Macáková, Tomáš Kučera, Martina Hrabinová, Daniel Jun
Publikováno v:
Molecules, Vol 24, Iss 7, p 1340 (2019)
In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+)-canadine (2) on human acetylcholinesterase (hAChE) and butyrylcholines
Externí odkaz:
https://doaj.org/article/4222d098d41c4d2aa46c3ac96c25eacb
Publikováno v:
Acta Medica, Vol 48, Iss 2, Pp 81-86 (2005)
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7,
Externí odkaz:
https://doaj.org/article/d9610ff90d454585a3529a1394200e58
Autor:
Tomáš Siatka, Markéta Adamcová, Lubomír Opletal, Lucie Cahlíková, Daniel Jun, Martina Hrabinová, Jiří Kuneš, Jakub Chlebek
Publikováno v:
Molecules, Vol 22, Iss 7, p 1181 (2017)
Alzheimer’s disease is an age-related, neurodegenerative disorder, characterized by cognitive impairment and restrictions in activities of daily living. This disease is the most common form of dementia with complex multifactorial pathological mecha
Externí odkaz:
https://doaj.org/article/2dc14400728245b2928137ec59f4c886
Autor:
Rudolf, Vrabec, Jana, Maříková, Miroslav, Ločárek, Jan, Korábečný, Daniela, Hulcová, Anna, Hošťálková, Jiří, Kuneš, Jakub, Chlebek, Tomáš, Kučera, Martina, Hrabinová, Daniel, Jun, Ondřej, Soukup, Vincenza, Andrisano, Jaroslav, Jenčo, Marcela, Šafratová, Lucie, Nováková, Lubomír, Opletal, Lucie, Cahlíková
Publikováno v:
Phytochemistry. 194
One undescribed indole alkaloid together with twenty-two known compounds have been isolated from aerial parts of Vinca minor L. (Apocynaceae). The chemical structures of the isolated alkaloids were determined by a combination of MS, HRMS, 1D, and 2D
Autor:
Eva Mezeiova, Lukas Prchal, Martina Hrabinova, Lubica Muckova, Lenka Pulkrabkova, Ondrej Soukup, Anna Misiachna, Jiri Janousek, Jakub Fibigar, Tomas Kucera, Martin Horak, Galina F. Makhaeva, Jan Korabecny
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 173, Iss , Pp 116399- (2024)
The search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called mu
Externí odkaz:
https://doaj.org/article/567776fbc85843eba2bb66f04d9469c0
Autor:
Chlebek, Tomáš Siatka, Markéta Adamcová, Lubomír Opletal, Lucie Cahlíková, Daniel Jun, Martina Hrabinová, Jiří Kuneš, Jakub
Publikováno v:
Molecules; Volume 22; Issue 7; Pages: 1181
Alzheimer’s disease is an age-related, neurodegenerative disorder, characterized by cognitive impairment and restrictions in activities of daily living. This disease is the most common form of dementia with complex multifactorial pathological mecha
Autor:
Jan, Bureš, Daniel, Jun, Martina, Hrabinová, Ilja, Tachecí, Jaroslav, Květina, Michal, Pavlík, Stanislav, Rejchrt, Tomáš, Douda, Martin, Kuneš, Kamil, Kuča, Marcela, Kopáčová
Publikováno v:
Neuro endocrinology letters. 36
Tacrine was the first acetylcholinesterase inhibitor approved for therapy of Alzheimer's disease. It has currently been withdrawn in some countries mostly due to the risk of hepatotoxicity and might be replaced by its derivate 7-methoxytacrine (7-MEO