Výsledky vyhledávání - "Martina Hýžďalová"

Changes in Sphingolipid Profile of Benzo[a]pyrene-Transformed Human Bronchial Epithelial Cells Are Reflected in the Altered Composition of Sphingolipids in Their Exosomes

Autor: Jan Kotouček, Steen Mollerup, Pavel Kulich, Josef Slavík, Martina Hýžďalová, Jiřina Procházková, Ondrej Kováč, Nicol Straková, Jan Vondráček, Kateřina Pěnčíková, Martina Pařenicová, Miroslav Machala

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 9195, p 9195 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 17

Sphingolipids (SLs), glycosphingolipids (GSLs), and eicosanoids are bioactive lipids, which play important roles in the etiology of various diseases, including cancer. However, their content and roles in cancer cells, and in particular in the exosome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb2306e9ad7656efedd5fb8d8cf78069
https://www.mdpi.com/1422-0067/22/17/9195

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A prolonged exposure of human lung carcinoma epithelial cells to benzo[a]pyrene induces p21-dependent epithelial-to-mesenchymal transition (EMT)-like phenotype

Autor: Zdeněk Andrysík, Radek Fedr, Josef Mašek, Miroslav Machala, Jan Topinka, Eva Hrubá, Simona Strapáčová, Lucie Svržková, Ondřej Vacek, Martina Hýžďalová, Jiří Kléma, Karel Souček, Jiřina Procházková, Jan Vondráček, Helena Libalova

Publikováno v: Chemosphere. 263:128126

Deciphering the role of the aryl hydrocarbon receptor (AhR) in lung cancer cells may help us to better understand the role of toxic AhR ligands in lung carcinogenesis, including cancer progression. We employed human lung carcinoma A549 cells to inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba21188f55f48542843fe4efe2482df
https://doi.org/10.1016/j.chemosphere.2020.128126

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Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells

Autor: Martina Hýžďalová, Jiří Neča, Miroslav Ciganek, Miroslav Machala, Jakub Pivnicka, Simona Strapáčová, Jan Topinka, Martina Karasová, Lenka Pálková, Alena Milcova, Kateřina Pěnčíková, Jason Matthews, Jan Vondráček, Michal Lom

Publikováno v: Environmental Pollution. 266:115125

The toxicities of many environmental polycyclic aromatic hydrocarbons (PAHs), in particular those of high-molecular-weight PAHs (with MW higher than 300), remain poorly characterized. The objective of this study was to evaluate the ability of selecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f629c92ea09073b8578aa98dda01fff
https://doi.org/10.1016/j.envpol.2020.115125

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In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion

Autor: Jakub Pivnička, Xueshu Li, Hans-Joachim Lehmler, Iveta Bartoňková, Zdeněk Dvořák, Jiří Neča, Martina Hýžďalová, Lucie Svržková, Jan Vondráček, Kateřina Pěnčíková, Lenka Pálková, Miroslav Machala, Simona Strapáčová

Publikováno v: Environmental pollution (Barking, Essex : 1987). 237

The mechanisms contributing to toxic effects of airborne lower-chlorinated PCB congeners (LC-PCBs) remain poorly characterized. We evaluated in vitro toxicities of environmental LC-PCBs found in both indoor and outdoor air (PCB 4, 8, 11, 18, 28 and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc55735edcdec4492ed308edf581ae6
https://pubmed.ncbi.nlm.nih.gov/29518658

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Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

Autor: Jaromír Mikeš, Rastislav Jendželovský, Alois Kozubík, Martina Hýžďalová, Peter Fedoročko, Alena Hyršlová Vaculová, Ján Kovaľ, Lenka Kočí, Jiřina Hofmanová

Publikováno v: Photochemicalphotobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 10(4)

Preferential uptake of photosensitizer by tumour tissue is an elementary prerequisite of effective and successful photodynamic therapy (PDT). Therefore intracellular concentration of photosensitizer is one of the limiting factors affecting PDT effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfd80b73822f8caec71f915627cfe53
https://pubmed.ncbi.nlm.nih.gov/21298151

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NF-κB is not directly responsible for photoresistance induced by fractionated light delivery in HT-29 colon adenocarcinoma cells

Autor: Jaromír Mikeš, Lucia Kuliková, Martina Hýžďalová, Peter Fedoročko, Giuseppe Palumbo

Publikováno v: Photochemistry and photobiology. 86(6)

Our recent study follows up an earlier one which demonstrated hypericin-mediated photocytotoxic effects on HT-29 adenocarcinoma cells by light fractionation with a longer dark pause between two unequal light doses (Sackova, A. [2005] Photochem. Photo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5e28bebf1a142d21fd1984b1cca526
https://pubmed.ncbi.nlm.nih.gov/20718930

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