Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Martina Hüttl"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimsRecent studies suggest that empagliflozin reduces total and cardiovascular mortality in both diabetic and nondiabetic subjects. Although the exact mechanism is unclear, it is understood to positively affect myocardial energetics, i
Externí odkaz:
https://doaj.org/article/fa2238b0f7a646cf9584cc6424377b21
Autor:
Silvie Hojná, Hana Malínská, Martina Hüttl, Zdeňka Vaňourková, Irena Marková, Denisa Miklánková, Jaroslav Hrdlička, František Papoušek, Jan Neckář, Petr Kujal, Michal Behuliak, Hana Rauchová, Michaela Kadlecová, David Sedmera, Kristýna Neffeová, Eva Zábrodská, Veronika Olejníčková, Josef Zicha, Ivana Vaněčková
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116520- (2024)
A combination of liver and heart dysfunction worsens the prognosis of human survival. The aim of this study was to investigate whether empagliflozin (a sodium-glucose transporter-2 inhibitor) has beneficial effects not only on cardiac and renal funct
Externí odkaz:
https://doaj.org/article/ce293d8af73640869fc6eca6e079b0bb
Publikováno v:
Antioxidants, Vol 13, Iss 6, p 627 (2024)
Menopause brings about profound physiological changes, including the acceleration of insulin resistance and other abnormalities, in which adipose tissue can play a significant role. This study analyzed the effect of ovariectomy and estradiol substitu
Externí odkaz:
https://doaj.org/article/768b7a49f78c4bcabab8cecc7d5212be
Autor:
Martina Hüttl, Irena Markova, Denisa Miklánková, Iveta Zapletalova, Petr Kujal, Jan Šilhavý, Michal Pravenec, Hana Malinska
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and aims: Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal anti-inflammatory
Externí odkaz:
https://doaj.org/article/43d18ec3736b4092867a31a16cc3da06
Autor:
Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop, Ludmila Kazdova
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 5, Pp 1889-1900 (2022)
The efficacy of fenofibrate in the treatment of hepatic steatosis has not been clearly demonstrated. In this study, we investigated the effects of fenofibrate and silymarin, administered as monotherapy and in combination to existing hepatic steatosis
Externí odkaz:
https://doaj.org/article/b82668e3dd6848b6afbb2ca9d5af9fdc
Autor:
Jan Silhavy, Petr Mlejnek, Miroslava Šimáková, Irena Marková, Hana Malínská, Martina Hüttl, Ludmila Kazdová, Dmitry Kazantsev, Massimiliano Mancini, Jiří Novotný, Michal Pravenec
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283276 (2023)
Thermogenesis in brown adipose tissue (BAT) uses intracellular triglycerides, circulating free fatty acids and glucose as the main substrates. The objective of the current study was to analyse the role of CD36 fatty acid translocase in regulation of
Externí odkaz:
https://doaj.org/article/35b76587320949d6a94477eed4b50a5f
Autor:
Anna N Senko, Rupert W Overall, Jan Silhavy, Petr Mlejnek, Hana Malínská, Martina Hüttl, Irena Marková, Klaus S Fabel, Lu Lu, Ales Stuchlik, Robert W Williams, Michal Pravenec, Gerd Kempermann
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1009638 (2022)
Neurogenesis in the adult hippocampus contributes to learning and memory in the healthy brain but is dysregulated in metabolic and neurodegenerative diseases. The molecular relationships between neural stem cell activity, adult neurogenesis, and glob
Externí odkaz:
https://doaj.org/article/888d224e99174f44824dc55a14e63450
Autor:
Jan Šilhavý, Petr Mlejnek, Miroslava Šimáková, Hana Malínská, Irena Marková, Martina Hüttl, Denisa Miklánková, Ludmila Kazdová, Marek Vrbacký, Alena Pecinová, Tomáš Mráček, Michal Pravenec
Publikováno v:
Metabolites, Vol 13, Iss 2, p 192 (2023)
Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying
Externí odkaz:
https://doaj.org/article/a687dbf6a0cc4fd38db94b4d81c78b08
Publikováno v:
Journal of Diabetes Research, Vol 2022 (2022)
Introduction. Monounsaturated fatty acids (MUFA) are understood to have therapeutic and preventive effects on chronic complications associated with type 2 diabetes mellitus (T2DM); however, there are differences between individual MUFAs. Although the
Externí odkaz:
https://doaj.org/article/26e94ca82d9c4cec87d8e861d37f6ebe
Autor:
Silvie Hojná, Hana Rauchová, Hana Malínská, Irena Marková, Martina Hüttl, František Papoušek, Michal Behuliak, Denisa Miklánková, Zdeňka Vaňourková, Jan Neckář, Michaela Kadlecová, Petr Kujal, Josef Zicha, Ivana Vaněčková
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112246- (2021)
The new antidiabetic drugs, gliflozins, inhibit sodium-glucose transporter-2 in renal proximal tubules promoting glucose and sodium excretion. This leads not only to a significant improvement of glucose control but also to the reduction of blood pres
Externí odkaz:
https://doaj.org/article/e201a9068c7440d880c7984feaa998e8