Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martina Giannaccini"'
Autor:
Patrizia Colucci, Martina Giannaccini, Matteo Baggiani, Breandán N. Kennedy, Luciana Dente, Vittoria Raffa, Chiara Gabellini
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1096 (2023)
Neuroprotective drug delivery to the posterior segment of the eye represents a major challenge to counteract vision loss. This work focuses on the development of a polymer-based nanocarrier, specifically designed for targeting the posterior eye. Poly
Externí odkaz:
https://doaj.org/article/9e283d5e21a04d8885aed0d715cd42b2
Autor:
Rosario Amato, Martina Giannaccini, Massimo Dal Monte, Maurizio Cammalleri, Alessandro Pini, Vittoria Raffa, Matteo Lulli, Giovanni Casini
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
The somatostatin analog octreotide (OCT) displays important neuroprotective and anti-angiogenic properties that could make it an interesting candidate to treat diabetic retinopathy (DR). Unfortunately, systemic drug administration is hindered by seve
Externí odkaz:
https://doaj.org/article/99cef67647f643bfbce42e789945abd0
Autor:
Martina Giannaccini, Marianna Giannini, M. Pilar Calatayud, Gerardo F. Goya, Alfred Cuschieri, Luciana Dente, Vittoria Raffa
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 1, Pp 1590-1605 (2014)
One of the most challenging efforts in drug delivery is the targeting of the eye. The eye structure and barriers render this organ poorly permeable to drugs. Quite recently the entrance of nanoscience in ocular drug delivery has improved the penetrat
Externí odkaz:
https://doaj.org/article/0ac4273a33834bf1acf2c6fe576792ae
Autor:
Marianna Giannini, Martina Giannaccini, Teresa Sibillano, Cinzia Giannini, Dun Liu, Zhigang Wang, Andrea Baù, Luciana Dente, Alfred Cuschieri, Vittoria Raffa
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115183 (2014)
All biomaterials initiate a tissue response when implanted in living tissues. Ultimately this reaction causes fibrous encapsulation and hence isolation of the material, leading to failure of the intended therapeutic effect of the implant. There has b
Externí odkaz:
https://doaj.org/article/831b81b1d5b84f84a2f9f3e96a2ebb03
Background: Zebrafish (Danio rerio) is a vertebrate that has become a popular alternative model for the cellular and molecular study of human tumors and for drug testing and validating approaches. Notably, zebrafish embryos, thanks to their accessibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483fe37946c58770d1522ad63019d440
https://hdl.handle.net/11568/1100592
https://hdl.handle.net/11568/1100592
Autor:
Liron Berger, Silke Hampel, Martina Giannaccini, Matteo Battaglini, Vittoria Raffa, Luciana Dente, Orazio Vittorio, Giuseppe Cirillo, Nicoletta di Leo
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 114:1-10
We validated the anticancer potential of a nanoformulation made by (+)-catechin, gelatin and carbon nanotubes in terms of inhibition of cancer cell proliferation, migration and associated neo-angiogenesis. Gelatin was selected to stabilize the catech
Autor:
Viviana Guadagni, Massimiliano Andreazzoli, Silvia Marracci, Davide Martini, Guido Giudetti, Martina Giannaccini
Collagen prolyl 4-hydroxylases (c-P4Hs) are evolutionary conserved enzymes whose activity is essential for the correct folding of stable triple helical molecules of collagen and collagen-like proteins. They play crucial roles in embryo development, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8f01fe2e492f9ed221a067b9cedfd9
https://hdl.handle.net/11568/1019181
https://hdl.handle.net/11568/1019181
Autor:
Massimiliano Andreazzoli, Luciana Dente, Massimo Pasqualetti, Alice Usai, Federica Chiellini, Martina Giannaccini, Michela Ori, Vittoria Raffa, Viviana Guadagni
Publikováno v:
Cellular and Molecular Life Sciences
Glaucoma and other optic neuropathies are characterized by a loss of retinal ganglion cells (RGCs), a cell layer located in the posterior eye segment. Several preclinical studies demonstrate that neurotrophins (NTs) prevent RGC loss. However, NTs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab6ae93deca73aafdc196e2091cac7a
http://hdl.handle.net/11568/876092
http://hdl.handle.net/11568/876092
Autor:
Alfred Cuschieri, Zhigang Wang, Liron Berger, Luciana Dente, Vittoria Raffa, Elena Landi, Giovanni Signore, Chiara Primerano, Martina Giannaccini, Marianna Giannini
Publikováno v:
Nanomedicine (Online) 14 (2018): 2656–2665. doi:10.1016/j.nano.2018.07.002
info:cnr-pdr/source/autori:Giannini M.; Primerano C.; Berger L.; Giannaccini M.; Wang Z.; Landi E.; Cuschieri A.; Dente L.; Signore G.; Raffa V./titolo:Nano-topography: Quicksand for cell cycle progression?/doi:10.1016%2Fj.nano.2018.07.002/rivista:Nanomedicine (Online)/anno:2018/pagina_da:2656/pagina_a:2665/intervallo_pagine:2656–2665/volume:14
info:cnr-pdr/source/autori:Giannini M.; Primerano C.; Berger L.; Giannaccini M.; Wang Z.; Landi E.; Cuschieri A.; Dente L.; Signore G.; Raffa V./titolo:Nano-topography: Quicksand for cell cycle progression?/doi:10.1016%2Fj.nano.2018.07.002/rivista:Nanomedicine (Online)/anno:2018/pagina_da:2656/pagina_a:2665/intervallo_pagine:2656–2665/volume:14
The 3-D spatial and mechanical features of nano-topography can create alternative environments, which influence cellular response. In this paper, murine fibroblast cells were grown on surfaces characterized by protruding nanotubes. Cells cultured on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfde892ae5d7276365273bacc3961dc6
http://www.scopus.com/inward/record.url?eid=2-s2.0-85050386504&partnerID=q2rCbXpz
http://www.scopus.com/inward/record.url?eid=2-s2.0-85050386504&partnerID=q2rCbXpz
Autor:
Silvia Marracci, Martina Giannaccini, Guido Giudetti, Luciana Dente, Massimiliano Andreazzoli, Davide Martini
Publikováno v:
The International Journal of Developmental Biology. 59:235-240
We recently identified pfdn6a and tcp1α (also known as cct-α) as genes coregulated by the transcription factor Rx1. The proteins encoded by these genes belong to two interacting complexes (Prefoldin and "chaperonin containing t-complex polypeptide