Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Martina Gentzsch"'
Autor:
Martina Gentzsch, Brooke Baker, Deborah M. Cholon, Charissa W. Kam, Cameron J. McKinzie, Katherine A. Despotes, Susan E. Boyles, Nancy L. Quinney, Charles R. Esther Jr, Carla M.P. Ribeiro
Publikováno v:
ERJ Open Research, Vol 10, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/5cb616064cad4b1f8847378b3ccbe961
Autor:
Deborah M. Cholon, Matthew A. Greenwald, Matthew G. Higgs, Nancy L. Quinney, Susan E. Boyles, Suzanne L. Meinig, John T. Minges, Ashlesha Chaubal, Robert Tarran, Carla M. P. Ribeiro, Matthew C. Wolfgang, Martina Gentzsch
Publikováno v:
Cells, Vol 12, Iss 22, p 2618 (2023)
People with cystic fibrosis (pwCF) suffer from chronic and recurring bacterial lung infections that begin very early in life and contribute to progressive lung failure. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR) ge
Externí odkaz:
https://doaj.org/article/ec9881276a44454fb50ae20ca5572f51
Autor:
Neil L. Harrison, Geoffrey W. Abbott, Martina Gentzsch, Andrei Aleksandrov, Anna Moroni, Gerhard Thiel, Stephen Grant, Colin G. Nichols, Henry A. Lester, Andreas Hartel, Kenneth Shepard, David Cabrera Garcia, Masayuki Yazawa
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/412f76ba93c044a085d835ada304e2f3
Autor:
Rhianna E. Lee, Catherine A. Lewis, Lihua He, Emily C. Bulik-Sullivan, Samuel C. Gallant, Teresa M. Mascenik, Hong Dang, Deborah M. Cholon, Martina Gentzsch, Lisa C. Morton, John T. Minges, Jonathan W. Theile, Neil A. Castle, Michael R. Knowles, Adam J. Kimple, Scott H. Randell
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with CF harbor premature termination codons (PTCs) or rare CFTR variants with limited treatment
Externí odkaz:
https://doaj.org/article/0342006f024949bb976f55db34ef1e17
Autor:
Martina Gentzsch, Deborah M. Cholon, Nancy L. Quinney, Mary E. B. Martino, John T. Minges, Susan E. Boyles, Tara N. Guhr Lee, Charles R. Esther, Carla M. P. Ribeiro
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The m
Externí odkaz:
https://doaj.org/article/0684a12ec8d9405d9a3000c14aebce39
Autor:
Jie Xu, Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song, Hong Jiang, Hong-Guang Wei, Hui Wang, Mohamad Bouhamdan, Jinxue Ruan, Dongshan Yang, Yining Qiu, Youming Xie, Ronald Barrett, Sharon McClellan, Hongmei Mou, Qingtian Wu, Xuequn Chen, Troy D. Rogers, Kristen J. Wilkinson, Rodney C. Gilmore, Charles R. Esther Jr., Khalequz Zaman, Xiubin Liang, Michael Sobolic, Linda Hazlett, Kezhong Zhang, Raymond A. Frizzell, Martina Gentzsch, Wanda K. O’Neal, Barbara R. Grubb, Y. Eugene Chen, Richard C. Boucher, Fei Sun
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of
Externí odkaz:
https://doaj.org/article/ff264f8cd5104415abd1eba07591062e
Publikováno v:
BMC Cell Biology, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Conditional reprogramming has enabled the development of long-lived, normal epithelial cell lines from mice and humans by in vitro culture with ROCK inhibitor on a feeder layer. We applied this technology to mouse small intestine
Externí odkaz:
https://doaj.org/article/53b32c4ca0fc4e6985453b97e228279d
Autor:
Carlos M. Farinha, Martina Gentzsch
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13196 (2021)
Remarkable progress in CFTR research has led to the therapeutic development of modulators that rescue the basic defect in cystic fibrosis. There is continuous interest in studying CFTR molecular disease mechanisms as not all cystic fibrosis patients
Externí odkaz:
https://doaj.org/article/6c2e16dcc163406ca4fd00859b8ff33d
Autor:
Carla M. P. Ribeiro, Martina Gentzsch
Publikováno v:
Cells, Vol 10, Iss 11, p 3260 (2021)
Defective CFTR biogenesis and activity in cystic fibrosis airways leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. Most cystic fibrosis patients have at least one copy of the F508
Externí odkaz:
https://doaj.org/article/f9f44a2056ee478cb0717cd119c96584
Autor:
Jarrod S Johnson, Martina Gentzsch, Liqun Zhang, Carla M P Ribeiro, Boris Kantor, Tal Kafri, Raymond J Pickles, R Jude Samulski
Publikováno v:
PLoS Pathogens, Vol 7, Iss 5, p e1002053 (2011)
Barriers to infection act at multiple levels to prevent viruses, bacteria, and parasites from commandeering host cells for their own purposes. An intriguing hypothesis is that if a cell experiences stress, such as that elicited by inflammation, endop
Externí odkaz:
https://doaj.org/article/2b7946ef397d4a6e8d1c9ac73552aa52