Výsledky vyhledávání - "Martina Fontaine"

First Results from the Dose Escalation Segment of the Phase I Clinical Study Evaluating Cyad-02, an Optimized Non Gene-Edited Engineered NKG2D CAR T-Cell Product, in Relapsed or Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients

Autor: Johan Maertens, Frederic Lehmann, Yves Beguin, David E. Gilham, Marie-Sophie Dheur, Caroline Lonez, Dries Deeren, Panagiota A. Sotiropoulou, Anne Flament, Eytan Breman, Nathalie Braun, Tara L. Lin, Benjamin Demoulin, Martina Fontaine, Erik Alcantar-Orozco

Publikováno v: Blood. 136:36-36

Background T-cells engineered to express a chimeric antigen receptor (CAR) based on the NKG2D receptor (NKG2D CAR) targeting the 8 NKG2D ligands (MICA/B, ULBP1-6) over-expressed by a large variety of malignancies have been developped to treat patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc815a6c4f75180d0a879dcf20f9ebf
https://doi.org/10.1182/blood-2020-139667

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Regulatory T cells constrain the TCR repertoire of antigen‐stimulated conventional CD4 T cells

Autor: Muriel Moser, Isabel Vogel, George Kassiotis, Adrien Galuppo, Martina Fontaine, Christine Decaestecker, Yves-Remi Van Eycke, Oberdan Leo, Yousra Ajouaou

To analyze the potential role of Tregs in controlling the TCR repertoire breadth to a non‐self‐antigen, a TCRβ transgenic mouse model (EF4.1) expressing a limited, yet polyclonal naive T‐cell repertoire was used. The response of EF4.1 mice to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c6b86aa47b2e0feb8f4de5674acfbe
https://europepmc.org/articles/PMC5793804/

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APOLs with low pH dependence can kill all African trypanosomes

Autor: Etienne Pays, Benoit Vanhollebeke, Laurence Lecordier, Patricia Tebabi, David Perez-Morga, Gilles Vanwalleghem, Martina Fontaine, Nick Van Reet, Philippe Büscher, Frédéric Fontaine, Pierrick Uzureau

Publikováno v: Nature microbiology
Nature Microbiology

The primate-specific serum protein apolipoprotein L1 (APOL1) is the only secreted member of a family of cell death promoting proteins 1-4 . APOL1 kills the bloodstream parasite Trypanosoma brucei brucei, but not the human sleeping sickness agents T.b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7f3edfb23e171e128755c6b81c4094

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