Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Martina Durcik"'
Publikováno v:
Slovenian Veterinary Research, Vol 61, Iss 2 (2024)
Antimicrobial resistance (AMR) is a concerning public health threat which affects human and animal health as well as the environment. The rapid spread of bacterial strains resistant to clinically used antibacterials necessitates the exploration and u
Externí odkaz:
https://doaj.org/article/6b56291e33514b7a829d4fd7cc0d793c
Autor:
Andrej Emanuel Cotman, Thomas Guérin, Ivana Kovačević, Davide Benedetto Tiz, Martina Durcik, Federica Fulgheri, Štefan Možina, Daniela Secci, Maša Sterle, Janez Ilaš, Anamarija Zega, Nace Zidar, Lucija Peterlin Mašič, Tihomir Tomašič, Frédéric R. Leroux, Gilles Hanquet, Danijel Kikelj
Publikováno v:
ACS Omega, Vol 6, Iss 14, Pp 9723-9730 (2021)
Externí odkaz:
https://doaj.org/article/9ba5d039df7149c1b22ceb9e931835a8
Autor:
Martina Durcik, Žan Toplak, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lucija Peterlin Mašič, Tihomir Tomašič
Publikováno v:
ACS Omega, Vol 5, Iss 14, Pp 8305-8311 (2020)
Externí odkaz:
https://doaj.org/article/4f43a3afa9774ebfa4eb99fa7ffa431e
Autor:
Akos Nyerges, Tihomir Tomašič, Martina Durcik, Tamas Revesz, Petra Szili, Gabor Draskovits, Ferenc Bogar, Žiga Skok, Nace Zidar, Janez Ilaš, Anamarija Zega, Danijel Kikelj, Lejla Daruka, Balint Kintses, Balint Vasarhelyi, Imre Foldesi, Diána Kata, Martin Welin, Raymond Kimbung, Dorota Focht, Lucija Peterlin Mašič, Csaba Pal
Publikováno v:
PLoS Biology, Vol 18, Iss 10, p e3000819 (2020)
Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics
Externí odkaz:
https://doaj.org/article/695667e264814dc5919d30b833577001
Autor:
Jaka Dernovšek, Živa Zajec, Martina Durcik, Lucija Peterlin Mašič, Martina Gobec, Nace Zidar, Tihomir Tomašič
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1283 (2021)
Heat shock protein 90 (Hsp90) is a chaperone responsible for the maturation of many cancer-related proteins, and is therefore an important target for the design of new anticancer agents. Several Hsp90 N-terminal domain inhibitors have been evaluated
Externí odkaz:
https://doaj.org/article/b49f7cc271014f1080fd907cb4d11058
Autor:
Martina Durcik, Žiga Skok, Janez Ilaš, Nace Zidar, Anamarija Zega, Petra Éva Szili, Gábor Draskovits, Tamás Révész, Danijel Kikelj, Akos Nyerges, Csaba Pál, Lucija Peterlin Mašič, Tihomir Tomašič
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 6 (2020)
The discovery of multi-targeting ligands of bacterial enzymes is an important strategy to combat rapidly spreading antimicrobial resistance. Bacterial DNA gyrase and topoisomerase IV are validated targets for the development of antibiotics. They can
Externí odkaz:
https://doaj.org/article/b21ef8c08f5f42f5bcc65fa01c759cd9
Autor:
Tihomir Tomašič, Martina Durcik, Bradley M. Keegan, Darja Gramec Skledar, Živa Zajec, Brian S. J. Blagg, Sharon D. Bryant
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6898 (2020)
Hsp90 C-terminal domain (CTD) inhibitors are promising novel agents for cancer treatment, as they do not induce the heat shock response associated with Hsp90 N-terminal inhibitors. One challenge associated with CTD inhibitors is the lack of a co-crys
Externí odkaz:
https://doaj.org/article/cba7f550859549e28530b0a56975bae5
Autor:
Lucas J. Gutierrez, Marcela Vettorazzi, Jaka Dernovšek, Martina Durcik, Lucija Peterlin Mašič, Tihomir Tomašič, Ricardo D. Enriz
Publikováno v:
New Journal of Chemistry. 47:3692-3702
Here we report a theoretical-experimental study of 4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine derivatives that act as inhibitors of bacterial DNA gyrase B (GyrB).
Autor:
Žiga Skok, Martina Durcik, Živa Zajec, Darja Gramec Skledar, Krištof Bozovičar, Anja Pišlar, Tihomir Tomašič, Anamarija Zega, Lucija Peterlin Mašič, Danijel Kikelj, Nace Zidar, Janez Ilaš
Publikováno v:
European journal of medicinal chemistry, vol. 115116, no. 249, pp. 1-21, 2023.
ATP-competitive inhibitors of human DNA topoisomerase II show potential for becoming the successors of topoisomerase II poisons, the clinically successful anticancer drugs. Based on our recent screening hits, we designed, synthesized and biologically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddec1086ebf39235825f1c215417d072
https://hdl.handle.net/20.500.12556/RUL-144331
https://hdl.handle.net/20.500.12556/RUL-144331
Autor:
Andrej Emanuel Cotman, Martina Durcik, Davide Benedetto Tiz, Federica Fulgheri, Daniela Secci, Maša Sterle, Štefan Možina, Žiga Skok, Nace Zidar, Anamarija Zega, Janez Ilaš, Lucija Peterlin Mašič, Tihomir Tomašič, Diarmaid Hughes, Douglas L. Huseby, Sha Cao, Linnéa Garoff, Talía Berruga Fernández, Paraskevi Giachou, Lisa Crone, Ivailo Simoff, Richard Svensson, Bryndis Birnir, Sergiy V. Korol, Zhe Jin, Francisca Vicente, Maria C. Ramos, Mercedes de la Cruz, Björn Glinghammar, Lena Lenhammar, Sara R. Henderson, Julia E. A. Mundy, Anthony Maxwell, Clare E. M. Stevenson, David M. Lawson, Guido V. Janssen, Geert Jan Sterk, Danijel Kikelj
Publikováno v:
Journal of medicinal chemistry, vol. 66, no. 2, 2023.
Journal of medicinal chemistry, str. 1380-1425 : Ilustr., Vol. 66, no. 2, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, 66(2), 1380-1425. American Chemical Society
Cotman, A E, Durcik, M, Benedetto Tiz, D, Fulgheri, F, Secci, D, Sterle, M, Možina, Š, Skok, Ž, Zidar, N, Zega, A, Ilaš, J, Peterlin Mašič, L, Tomašič, T, Hughes, D, Huseby, D L, Cao, S, Garoff, L, Berruga Fernández, T, Giachou, P, Crone, L, Simoff, I, Svensson, R, Birnir, B, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, De La Cruz, M, Glinghammar, B, Lenhammar, L, Henderson, S R, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Janssen, G V, Sterk, G J & Kikelj, D 2023, ' Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa ', Journal of medicinal chemistry, vol. 66, no. 2, pp. 1380-1425 . https://doi.org/10.1021/acs.jmedchem.2c01597
Journal of medicinal chemistry, str. 1380-1425 : Ilustr., Vol. 66, no. 2, 2023
COBISS-ID: 512806681
Journal of medicinal chemistry, 66(2), 1380-1425. American Chemical Society
Cotman, A E, Durcik, M, Benedetto Tiz, D, Fulgheri, F, Secci, D, Sterle, M, Možina, Š, Skok, Ž, Zidar, N, Zega, A, Ilaš, J, Peterlin Mašič, L, Tomašič, T, Hughes, D, Huseby, D L, Cao, S, Garoff, L, Berruga Fernández, T, Giachou, P, Crone, L, Simoff, I, Svensson, R, Birnir, B, Korol, S V, Jin, Z, Vicente, F, Ramos, M C, De La Cruz, M, Glinghammar, B, Lenhammar, L, Henderson, S R, Mundy, J E A, Maxwell, A, Stevenson, C E M, Lawson, D M, Janssen, G V, Sterk, G J & Kikelj, D 2023, ' Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa ', Journal of medicinal chemistry, vol. 66, no. 2, pp. 1380-1425 . https://doi.org/10.1021/acs.jmedchem.2c01597
We have developed compounds with a promising activity against Acinetobacter baumannii and Pseudomonas aeruginosa, which are both on the WHO priority list of antibiotic-resistant bacteria. Starting from DNA gyrase inhibitor 1, we identified compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20d28e0e61c3b400f08f6903958d25f
https://repozitorij.uni-lj.si/Dokument.php?id=166579&dn=
https://repozitorij.uni-lj.si/Dokument.php?id=166579&dn=