Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Martina Chrudinova"'
Autor:
Francois Moreau, Nicholas S. Kirk, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal, Michael C. Lawrence, Veronica Jimenez, Fatima Bosch, John J. Kopchick, Richard D. DiMarchi, Emrah Altindis, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R
Externí odkaz:
https://doaj.org/article/bfab9e0851234eeaa306dca00cc42caa
Autor:
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101121- (2021)
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to hu
Externí odkaz:
https://doaj.org/article/6021b0b3fea045b7b555497608ce50e0
Autor:
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are no
Externí odkaz:
https://doaj.org/article/cd3027437e574e159af8775f069f9003
Autor:
Khyati Girdhar, Yusuf Dogus Dogru, Qian Huang, Yi Yang, Vladimir Tolstikov, Amol Raisingani, Martina Chrudinova, Jaewon Oh, Kristina Kelley, Jonas F. Ludvigsson, Michael A. Kiebish, Noah W. Palm, Johnny Ludvigsson, Emrah Altindis
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background Celiac disease (CD) is an autoimmune disorder triggered by gluten consumption. Almost all CD patients possess human leukocyte antigen (HLA) DQ2/DQ8 haplotypes; however, only a small subset of individuals carrying these alleles dev
Externí odkaz:
https://doaj.org/article/90ee455b198944da9eb5694319c0b5a9
Autor:
Khyati Girdhar, Qian Huang, Yusuf Dogus Dogru, Yi Yang, Vladimir Tolstikov, Martina Chrudinova, Amol Raisingani, Jonas F. Ludvigsson, Michael A. Kiebish, Noah W. Palm, Johnny Ludvigsson, Emrah Altindis
SUMMARYCeliac disease (CD) is an autoimmune disorder triggered by gluten consumption. To identify the role of gut microbes in CD onset, we performed a longitudinal study focusing on two important phases of gut microbiota development at ages 2.5 and 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e7cbf7d422f697a2d41debbe3b365f
https://doi.org/10.1101/2020.02.29.971242
https://doi.org/10.1101/2020.02.29.971242
Autor:
Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 profor
Externí odkaz:
https://doaj.org/article/a75353d92d0a4e7788613a21e0db85e9
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02