Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Martina Chrudinová"'
Autor:
Martina Chrudinová, Nicholas S. Kirk, Aurelien Chuard, Hari Venugopal, Fa Zhang, Marta Lubos, Vasily Gelfanov, Terezie Páníková, Lenka Žáková, Julianne Cutone, Matthew Mojares, Richard DiMarchi, Jiří Jiráček, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 80, Iss , Pp 101863- (2024)
Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study
Externí odkaz:
https://doaj.org/article/7c5f60a2f83f44fdb26861620a039b02
Autor:
Pavlo Potalitsyn, Lucie Mrázková, Irena Selicharová, Michaela Tencerová, Michaela Ferenčáková, Martina Chrudinová, Tereza Turnovská, Andrzej Marek Brzozowski, Aleš Marek, Jakub Kaminský, Jiří Jiráček, Lenka Žáková
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 profor
Externí odkaz:
https://doaj.org/article/a75353d92d0a4e7788613a21e0db85e9
Autor:
Francois Moreau, Nicholas S. Kirk, Fa Zhang, Vasily Gelfanov, Edward O. List, Martina Chrudinová, Hari Venugopal, Michael C. Lawrence, Veronica Jimenez, Fatima Bosch, John J. Kopchick, Richard D. DiMarchi, Emrah Altindis, C. Ronald Kahn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The authors previously identified a family of viral insulin-like peptides (VILPs) with high homology to human insulin/IGF−1. Here, they report that one of these VILPs exhibits antagonist properties associated with a unique conformation of the IGF1R
Externí odkaz:
https://doaj.org/article/bfab9e0851234eeaa306dca00cc42caa
Autor:
Martina Chrudinová, François Moreau, Hye Lim Noh, Terezie Páníková, Lenka Žáková, Randall H. Friedline, Francisco A. Valenzuela, Jason K. Kim, Jiří Jiráček, C. Ronald Kahn, Emrah Altindis
Publikováno v:
Molecular Metabolism, Vol 44, Iss , Pp 101121- (2021)
Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to hu
Externí odkaz:
https://doaj.org/article/6021b0b3fea045b7b555497608ce50e0
Autor:
Petra Dzianová, Seiya Asai, Martina Chrudinová, Lucie Kosinová, Pavlo Potalitsyn, Pavel Šácha, Romana Hadravová, Irena Selicharová, Jan Kříž, Johan P. Turkenburg, Andrzej Marek Brzozowski, Jiří Jiráček, Lenka Žáková
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are no
Externí odkaz:
https://doaj.org/article/cd3027437e574e159af8775f069f9003
Autor:
Anja Muždalo, Katarína Mitrová, Irena Selicharová, Ondřej Socha, Miloš Buděšínský, Pavlo Potalitsyn, Jelena Radosavljević, Michaela Černeková, Milan Fábry, Martina Chrudinová, Lenka Žáková, Jingjing Lin, Martin Lepšík, Kateřina Hanková, Kateřina Macháčková, Květoslava Mlčochová, Jiří Jiráček, Pavel Hobza, Yevgen P. Yurenko
Publikováno v:
The Journal of Biological Chemistry
Information on how insulin and insulin-like growth factors 1 and 2 (IGF-1 and -2) activate insulin receptors (IR-A and -B) and the IGF-1 receptor (IGF-1R) is crucial for understanding the difference in the biological activities of these peptide hormo
Autor:
Irena Selicharová, Jan Pícha, Terezie Páníková, Lenka Žáková, Andrii Kurochka, Martina Chrudinová, Katarína Mitrová, Jiří Jiráček, Karolína Mrzílková, Tereza Halamová
Publikováno v:
Journal of medicinal chemistry. 64(19)
Insulin is a lifesaver for millions of diabetic patients. There is a need for new insulin analogues with more physiological profiles and analogues that will be thermally more stable than human insulin. Here, we describe the chemical engineering of 48
Autor:
Amaya Powis, Tu Tran, Emrah Altindis, Martina Chrudinová, Kaan Sevgi, Yusuf Dogus Dogru, Khyati Girdhar, Amol Raisingani, Ruixu Huang
Publikováno v:
Annual review of virology. 8(1)
Over the past decades, there have been tremendous efforts to understand the cross-talk between viruses and host metabolism. Several studies have elucidated the mechanisms through which viral infections manipulate metabolic pathways including glucose,
Autor:
Amaya Powis, Julianne Cutone, Emrah Altindis, Martina Chrudinová, Kaan Sevgi, Jiri Jiracek, Richard Dimarchi, Vasily Gelfanov, Lenka Zakova
Publikováno v:
Diabetes. 70
Our recent studies published in PNAS and Molecular Metabolism showed for the very first time that viruses possess genes encoding viral insulin/IGF-1 like peptides (VILPs). These two studies provided several important insights on VILPs: 1. Identified
Autor:
Ondřej Socha, Jiří Jiráček, Kateřina Macháčková, Aleš Marek, Lenka Žáková, Irena Selicharová, Jan Pícha, Martin Hubálek, Martina Chrudinová, Miloš Buděšínský
Publikováno v:
The Journal of Biological Chemistry
Insulin and insulin-like growth factor 1 (IGF-1) are closely related hormones involved in the regulation of metabolism and growth. They elicit their functions through activation of tyrosine kinase–type receptors: insulin receptors (IR-A and IR-B) a