Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Martina Beretta"'
Autor:
Riya Shrestha, Calum S. Vancuylenburg, Martina Beretta, Mingyan Zhou, Divya P. Shah, Ellen M. Olzomer, Sian L. Richards, Kyle L. Hoehn, Frances L. Byrne
Publikováno v:
Cancer & Metabolism, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Background The metabolic pathway of de novo lipogenesis (DNL) is upregulated in fatty liver disease and liver cancer. Inhibitors of DNL are in development for the treatment of these disorders; however, our previous study showed that blocking
Externí odkaz:
https://doaj.org/article/a90ba229d3e74b79b98ae71a6d283af0
Autor:
Sing-Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y.H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101684- (2023)
Objective: Calorie restriction is a first-line treatment for overweight individuals with metabolic impairments. However, few patients can adhere to long-term calorie restriction. An alternative approach to calorie restriction that also causes negativ
Externí odkaz:
https://doaj.org/article/e475640495114e8b9f51a21417a66099
Autor:
Elizabeth R. M. Zunica, Christopher L. Axelrod, Eunhan Cho, Guillaume Spielmann, Gangarao Davuluri, Stephanie J. Alexopoulos, Martina Beretta, Kyle L. Hoehn, Wagner S. Dantas, Krisztian Stadler, William T. King, Kathryn Pergola, Brian A. Irving, Ingeborg M. Langohr, Shengping Yang, Charles L. Hoppel, L. Anne Gilmore, John P. Kirwan
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Background Enhanced metabolic plasticity and diversification of energy production is a hallmark of highly proliferative breast cancers. This contributes to poor pharmacotherapy efficacy, recurrence, and metastases. We have previously identif
Externí odkaz:
https://doaj.org/article/73646908050a40a890022b3871277182
Autor:
Adrian T Press, Petra Babic, Bianca Hoffmann, Tina Müller, Wanling Foo, Walter Hauswald, Jovana Benecke, Martina Beretta, Zoltán Cseresnyés, Stephanie Hoeppener, Ivo Nischang, Sina M Coldewey, Markus H Gräler, Reinhard Bauer, Falk Gonnert, Nikolaus Gaßler, Reinhard Wetzker, Marc Thilo Figge, Ulrich S Schubert, Michael Bauer
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-17 (2021)
Abstract Jaundice, the clinical hallmark of infection‐associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3‐kinase‐γ (PI3Kγ) are
Externí odkaz:
https://doaj.org/article/0fad10ab812d436c8a511f93c2eb66d8
Autor:
Stephanie J. Alexopoulos, Sing-Young Chen, Amanda E. Brandon, Joseph M. Salamoun, Frances L. Byrne, Christopher J. Garcia, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Ashleigh M. Philp, Stefan R. Hargett, Robert T. Lawrence, Brendan Lee, James Sligar, Pascal Carrive, Simon P. Tucker, Andrew Philp, Carolin Lackner, Nigel Turner, Gregory J. Cooney, Webster L. Santos, Kyle L. Hoehn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Obesity is a global pandemic with limited treatment options. Here, the authors show evidence in mice that the mitochondrial uncoupler BAM15 effectively induces fat loss without affecting food intake or compromising lean body mass.
Externí odkaz:
https://doaj.org/article/49822901a6bc47aea8285786f6119e85
Autor:
Jacob H. Murray, Ariel L. Burgio, Martina Beretta, Stefan R. Hargett, Thurl E. Harris, Ellen Olzomer, R. Justin Grams, Christopher J. Garcia, Catherine Li, Joseph M. Salamoun, Kyle L. Hoehn, Webster L. Santos
Publikováno v:
Journal of Medicinal Chemistry. 66:3876-3895
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::431ad6692206e016380422ebbca53dbe
https://doi.org/10.1021/acs.jmedchem.2c01573
https://doi.org/10.1021/acs.jmedchem.2c01573
Autor:
Joseph M. Salamoun, Stefan R. Hargett, Martina Beretta, Stephanie J. Alexopoulos, Ellen M. Olzomer, Divya P. Shah, Murray Jacob H, Webster L. Santos, Sing-Young Chen, Christopher J Garcia, Simon P. Tucker, Kyle L. Hoehn
Publikováno v:
Journal of Medicinal Chemistry. 63:6203-6224
Small molecule mitochondrial uncouplers have recently garnered great interest for their potential in treating nonalcoholic steatohepatitis (NASH). In this study, we report the structure-activity relationship profiling of a 6-amino[1,2,5]oxadiazolo[3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63cb88300c0a0b76288986ff05d70645
https://doi.org/10.1021/acs.jmedchem.0c00542
https://doi.org/10.1021/acs.jmedchem.0c00542
Autor:
Sing-Young Chen, Ellen M. Olzomer, Martina Beretta, James Cantley, Craig S. Nunemaker, Kyle L. Hoehn, Frances L. Byrne
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9798
Obesity-related insulin resistance is a highly prevalent and growing health concern, which places stress on the pancreatic islets of Langerhans by increasing insulin secretion to lower blood glucose levels. The glucose transporters GLUT1 and GLUT3 pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb3bddf9a9c2df1eb7c267daace51ce
https://doi.org/10.3390/ijms23179798
https://doi.org/10.3390/ijms23179798
Autor:
Falk A. Gonnert, J. Benecke, Martina Beretta, Petra Babic, Adrian T. Press, Walter Hauswald, Reinhard Wetzker, N. Gassler, Sina M. Coldewey, T. Mueller, Bianca Hoffmann, Ivo Nischang, Zoltán Cseresnyés, M. H. Graeler, Michael Bauer, S. Hoeppner, Ulrich S. Schubert, Marc Thilo Figge, W. Foo, Reinhard Bauer
Jaundice, the clinical hallmark of infection-associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3-kinase-γ (PI3Kγ) are protected agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714f0d199a1fac4e6c83f3f565e4abf9
https://doi.org/10.1101/2021.01.20.427305
https://doi.org/10.1101/2021.01.20.427305
Autor:
Cristian Ruiz-Moreno, Anne Eugster, Martina Beretta, Franziska Roestel, Elisa Jentho, Michael Bauer, Tatyana Grinenko, Hendrik G. Stunnenberg, Mihai G. Netea, Lydia Kalafati, Boris Novakovic, Ioannis Kourtzelis, Wout Megchelenbrink, Triantafyllos Chavakis, Peter Bohm, Rui Martins, Sebastian Weis, Leo A. B. Joosten, Maren Godmann, Joel Guerra, Miguel P. Soares
Publikováno v:
Proceedings of the National Academy of Sciences USA, 118
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme
Proceedings of the National Academy of Sciences USA, 118, 42
Proceedings of the National Academy of Sciences of the United States of America
Trained innate immunity, long-lasting epigenetic modulation, and skewed myelopoiesis by heme
Proceedings of the National Academy of Sciences USA, 118, 42
Proceedings of the National Academy of Sciences of the United States of America
Significance During infection, extracellular “labile” heme, released from damaged red blood or parenchymal cells, acts as prototypical alarmin stimulating myeloid cells. A characteristic hallmark of myeloid cell activation is the development of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802e6edb735c52a46acd58d3c5652396
https://doi.org/10.1073/pnas.2102698118
https://doi.org/10.1073/pnas.2102698118