Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Autor: Hannah Zillikens, Anika Kasprick, Colin Osterloh, Natalie Gross, Michael Radziewitz, Cindy Hass, Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Katharina Boch, Gestur Vidarsson, Remco Visser, Tamás Laskay, Xinhua Yu, Frank Petersen, Ralf J. Ludwig, Katja Bieber

Publikováno v: Frontiers in Medicine, Vol 8 (2021)

Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies. Mechanistically, inhibition of specif

Externí odkaz: https://doaj.org/article/f680efe172b14190b7d5e11bac1d1a15

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

Autor: Katja Bieber, Shijie Sun, Mareike Witte, Anika Kasprick, Foteini Beltsiou, Martina Behnen, Tamás Laskay, Franziska S. Schulze, Elena Pipi, Niklas Reichhelm, René Pagel, Detlef Zillikens, Enno Schmidt, Tim Sparwasser, Kathrin Kalies, Ralf J. Ludwig

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Regulatory T cells (Tregs) are well known for their modulatory functions in adaptive immunity. Through regulation of T cell functions, Tregs have also been demonstrated to indirectly curb myeloid cell-driven inflammation. However, direct effects of T

Externí odkaz: https://doaj.org/article/d50872d56e25469c8896cd88f14dda80

Flavonoids and 5-Aminosalicylic Acid Inhibit the Formation of Neutrophil Extracellular Traps

Autor: Tina Kirchner, Eva Hermann, Sonja Möller, Matthias Klinger, Werner Solbach, Tamás Laskay, Martina Behnen

Publikováno v: Mediators of Inflammation, Vol 2013 (2013)

Neutrophil extracellular traps (NETs) have been suggested to play a pathophysiological role in several autoimmune diseases. Since NET-formation in response to several biological and chemical stimuli is mostly ROS dependent, in theory any substance th

Externí odkaz: https://doaj.org/article/a6824a7a74e747ce9899094203b40455

Topical Application of the PI3Kβ-Selective Small Molecule Inhibitor TGX-221 Is an Effective Treatment Option for Experimental Epidermolysis Bullosa Acquisita

Autor: Veronika Hartmann, Martina Behnen-Härer, Nancy Ernst, Gestur Vidarsson, Katja Bieber, Frank Petersen, Ralf Ludwig, Anika Kasprick, Colin Osterloh, Katharina Boch, Tamás Laskay, Michael Radziewitz, Cindy Hass, Natalie Gross, Xinhua Yu, Remco Visser, Hannah Zillikens

Publikováno v: Frontiers in Medicine, Vol 8 (2021)
Frontiers in Medicine, 8:713312. Frontiers Media S.A.
Frontiers in Medicine, 8, 1. Frontiers Media S.A.
Frontiers in Medicine

Class I phosphoinositide 3-kinases (PI3K) have been implemented in pathogenesis of experimental epidermolysis bullosa acquisita (EBA), an autoimmune skin disease caused by type VII collagen (COL7) autoantibodies. Mechanistically, inhibition of specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec9ee422b26f8e792b270115f960bce
https://www.frontiersin.org/articles/10.3389/fmed.2021.713312/full

Immobilized Immune Complexes Induce Neutrophil Extracellular Trap Release by Human Neutrophil Granulocytes via FcγRIIIB and Mac-1

Autor: Christoph Leschczyk, Tamás Laskay, Tobit Batel, Sonja Möller, Werner Solbach, Martina Behnen, Matthias Klinger

Publikováno v: The Journal of Immunology. 193:1954-1965

Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular traps (NETs), can result in severe pathology. Activation of neutrophils through immune compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18911856160b618edbbbf85277384a7
https://doi.org/10.4049/jimmunol.1400478