Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Martina Böttner"'
Autor:
Madlen Kunke, Hannah Knöfler, Eileen Dahlke, Luis Zanon Rodriguez, Martina Böttner, Alexey Larionov, Makhabbat Saudenova, Gerrit M. Ohrenschall, Magdalena Westermann, Stefan Porubsky, Joana P. Bernardes, Robert Häsler, Jean-Luc Magnin, Hermann Koepsell, François Jouret, Franziska Theilig
Publikováno v:
Cell Death and Disease, Vol 14, Iss 8, Pp 1-15 (2023)
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. Glomerular hyperfiltration and albuminuria subject the proximal tubule (PT) to a subsequent elevation of workload, growth, and hypoxia. Hypoxia plays an ambiguous
Externí odkaz:
https://doaj.org/article/1d09297137c0436ba5385716be600ed8
Autor:
Eva Schaeffer, Annika Kluge, Martina Böttner, Friederike Zunke, Francois Cossais, Daniela Berg, Philipp Arnold
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Parkinson’s disease (PD) is marked by different kinds of pathological features, one hallmark is the aggregation of α-synuclein (aSyn). The development of aSyn pathology in the substantia nigra is associated to the manifestation of motor deficits a
Externí odkaz:
https://doaj.org/article/bb702b3424a24bea8a4bb08b2046051e
Autor:
Martina Barrenschee, François Cossais, Martina Böttner, Jan-Hendrik Egberts, Thomas Becker, Thilo Wedel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Neuregulin 1 (NRG1) regulates the expression of the nicotinic acetylcholine receptor (nAChR) and is suggested to promote the survival and maintenance of the enteric nervous system (ENS), since deficiency of its corresponding receptor complex ErbB2/Er
Externí odkaz:
https://doaj.org/article/7e75bd291d43452095db613f1e8b382b
Autor:
Martina Barrenschee, Thilo Wedel, Christina Lange, Ines Hohmeier, François Cossais, Michael Ebsen, Ilka Vogel, Martina Böttner
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171416 (2017)
BACKGROUND:Glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor known to promote the survival and maintenance of neurons not only in the developing but also in the adult enteric nervous system. As diverticular disease (D
Externí odkaz:
https://doaj.org/article/fbab108254894939bbc29e258a35b9bc
Autor:
Martina Böttner, Dimitri Zorenkov, Ines Hellwig, Martina Barrenschee, Jonas Harde, Tobias Fricke, Günther Deuschl, Jan-Hendrik Egberts, Thomas Becker, Annette Fritscher-Ravens, Alexander Arlt, Thilo Wedel
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 3, Pp 474-480 (2012)
Background: Alpha-synuclein (α-syn) is abundantly expressed in the central nervous system and involved in the regulation of neurotransmission. Insoluble fibrils of phosphorylated α-synuclein (p-α-syn) have been implicated in several neurodegenerat
Externí odkaz:
https://doaj.org/article/7cf66c8ba99d4fc6b93e3a91bf221f38
Autor:
Martina Böttner, Martina Barrenschee, Ines Hellwig, Jonas Harde, Jan-Hendrik Egberts, Thomas Becker, Dimitri Zorenkov, Karl-Herbert Schäfer, Thilo Wedel
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66290 (2013)
Absence of glial cell line-derived neurotrophic factor (GDNF) leads to intestinal aganglionosis. We recently demonstrated that patients with diverticular disease (DD) exhibit hypoganglionosis suggesting neurotrophic factor deprivation. Thus, we scree
Externí odkaz:
https://doaj.org/article/fcfb5cad020447c9b6411b2d42b990e9
Autor:
Martina Böttner, Géraldine Bolen, Souad Rahmouni, Pascal Rowart, Franziska Theilig, Eileen Dahlke, Matthew P. Stokes, Laurence Poma, François Jouret, Badr Khbouz
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 234(2)
Aim Dual Specificity Phosphatase 3 (DUSP3) regulates the innate immune response, with a putative role in angiogenesis. Modulating inflammation and perfusion contributes to renal conditioning against ischemia/reperfusion (I/R). We postulate that the f
Autor:
Martina Böttner, Géraldine Bolen, Badr Khbouz, Franziska Theilig, Souad Rahmouni, Laurence Poma, François Jouret, Pascal Rowart
Publikováno v:
Nephrology Dialysis Transplantation. 36
Background and Aims Dual Specificity Phosphatase 3 (DUSP3) is a positive regulator of the innate immune response in case of sepsis, but its role in the ischemic damage is unknown. Here, we study (i) whether and where DUSP3 is expressed in the renal p
Autor:
François Cossais, Martina Böttner, Christina Lange, Ilka Vogel, Thilo Wedel, Martina Barrenschee, Michael Ebsen, Sebastian Leuschner
Publikováno v:
Journal of Clinical Gastroenterology. 53:449-456
Diverticular disease (DD) is a common gastrointestinal inflammatory disorder associated with an enteric neuropathy. Although enteric glial cells (EGCs) are essential regulators of intestinal inflammation and motility functions, their contribution to
Autor:
Mauro D'Amato, Robert Grützmann, Ilka Vogel, Andreas Walther-Berends, Thomas Becker, Frank Lammert, Michael Schroeder, Petr Sergeev, Laura Sophie Noack, Jürgen Tepel, Jonas Rosendahl, A Herrmann, Thilo Wedel, Clemens Schafmayer, Witigo von Schönfels, Patrick Michl, Wolfgang Kruis, Michael Krawczak, Bodo Schniewind, Holger Hinrichsen, Gerd Focke, Hans Wolfgang Schimming, Ursula Huber-Schönauer, Christina Lange, Sebastian Wolff, Thorsten Jacobi, RV Thangapandi, James W. Harrison, Robin N Beaumont, Philipp Hofer, Martina Böttner, Juozas Kupcinskas, Henry Völzke, Melanie Langheinrich, Christian Datz, Hans Boedeker, Jens Uwe Erk, Mario Brosch, Jessica Tyrrell, Andreas Volk, Andre Franke, Torsten Kucharzik, Leonora Pietsch, Andrew R. Wood, Greta Burmeister, Stephan Buch, Alexander Hendricks, Wolfgang Lieb, Limas Kupčinskas, Juergen Weitz, Michael N. Weedon, François Cossais, Jochen Hampe, Andrea Gsur, Myrko Zobel, Peter T. Schmidt, Stefan Palm, Matthias C. Reichert, Sebastian Hinz, Sebastian Zeissig, Anna Andreasson, Stefanie Brezina, Gernot Leeb
Publikováno v:
Gut
ObjectiveDiverticular disease is a common complex disorder characterised by mucosal outpouchings of the colonic wall that manifests through complications such as diverticulitis, perforation and bleeding. We report the to date largest genome-wide asso