Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Martina, Kovarova"'
Autor:
Lijun Ling, Manse Kim, Andrew Soper, Martina Kovarova, Rae Ann Spagnuolo, Nurjahan Begum, Jennifer Kirchherr, Nancie Archin, Diana Battaglia, Dave Cleveland, Angela Wahl, David M. Margolis, Edward P. Browne, J. Victor Garcia
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART). In an ex vivo model system of HIV latency
Externí odkaz:
https://doaj.org/article/11242e5bc7854ce8b4f92e9d3644d4a7
Autor:
Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D Falcinelli, Nancie M Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M Margolis, J Victor Garcia
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011824 (2023)
Lifelong treatment is required for people living with HIV as current antiretroviral therapy (ART) does not eradicate HIV infection. Latently infected cells are essentially indistinguishable from uninfected cells and cannot be depleted by currently av
Externí odkaz:
https://doaj.org/article/a87f849c7c8a4bcfb65f46e62f664ed6
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Ultra-long-acting delivery platforms for HIV pre-exposure prophylaxis (PrEP) may increase adherence and maximize public health benefit. We report on an injectable, biodegradable, and removable in-situ forming implant (ISFI) that is administe
Externí odkaz:
https://doaj.org/article/8c9e1df2e9064777a30af13581288fca
Autor:
Martina Kovarova, Sarah E. Wessel, Claire E. Johnson, Shelby V. Anderson, Mackenzie L. Cottrell, Craig Sykes, Myron S. Cohen, J. Victor Garcia
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Sexually transmitted HIV infections in heterosexual men are acquired through the penis. Low adherence to condom usage and the fact that 40% of circumcised men are not protected indicate the need for additional prevention strategies. Here, we
Externí odkaz:
https://doaj.org/article/ec56440736f9410ca761074b6dce7af6
Autor:
Isabella C. Young, Ivana Massud, Mackenzie L. Cottrell, Roopali Shrivastava, Panita Maturavongsadit, Alka Prasher, Andres Wong-Sam, Chuong Dinh, Tiancheng Edwards, Victoria Mrotz, James Mitchell, Josilene Nascimento Seixas, Aryani Pallerla, Allison Thorson, Amanda Schauer, Craig Sykes, Gabriela De la Cruz, Stephanie A. Montgomery, Angela D. M. Kashuba, Walid Heneine, Charles W. Dobard, Martina Kovarova, J. Victor Garcia, J. Gerardo Garcίa-Lerma, S. Rahima Benhabbour
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6a18aab38ad64106a8e0e7466f66fcbe
Autor:
Manse Kim, Claire E. Johnson, Alan A. Schmalstig, Ayano Annis, Sarah E. Wessel, Brian Van Horn, Amanda Schauer, Agata A. Exner, Jason E. Stout, Angela Wahl, Miriam Braunstein, J. Victor Garcia, Martina Kovarova
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Non-adherence to anti-tubercular therapy Mycobacterium tuberculosis infection can lead to treatment failure and even the development of drug resistance. In this work, the authors develop a long-acting delivery system of the anti-tuberculosis drug rif
Externí odkaz:
https://doaj.org/article/78ca0bb18972453d8ccd4f196de8996e
Autor:
Panita Maturavongsadit, Gayane Paravyan, Martina Kovarova, J. Victor Garcia, S. Rahima Benhabbour
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100068- (2021)
We present a long-acting (LA) biodegradable polymeric solid implant (PSI) fabricated using a new process combining in-situ phase inversion and compression. This robust process allows fabrication of solid implants that can have different shapes and si
Externí odkaz:
https://doaj.org/article/1568ea48d08f457d9ec41a608ff9e248
Autor:
S. Rahima Benhabbour, Martina Kovarova, Clinton Jones, Daijha J. Copeland, Roopali Shrivastava, Michael D. Swanson, Craig Sykes, Phong T. Ho, Mackenzie L. Cottrell, Anush Sridharan, Samantha M. Fix, Orrin Thayer, Julie M. Long, Daria J. Hazuda, Paul A. Dayton, Russell J. Mumper, Angela D. M. Kashuba, J. Victor Garcia
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrat
Externí odkaz:
https://doaj.org/article/8bc4a989ec17413397ece8fc45f93686
Autor:
Martina Kovarova, S. Rahima Benhabbour, Ivana Massud, Rae Ann Spagnuolo, Brianna Skinner, Caroline E. Baker, Craig Sykes, Katie R. Mollan, Angela D. M. Kashuba, J. Gerardo García-Lerma, Russell J. Mumper, J. Victor Garcia
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Long-acting (LA) formulations of antiretroviral (ARV) drugs are an alternative approach to improve adherence for HIV treatment and prevention. Here the authors show a removable biodegradable ultra-LA-ARV drug system that effectively delivers drug, co
Externí odkaz:
https://doaj.org/article/2eb550bf31b74367b1026c950200b662
Autor:
Uma Shanmugasundaram, Martina Kovarova, Phong T Ho, Nathaniel Schramm, Angela Wahl, Michael A Parniak, J Victor Garcia
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159517 (2016)
The nucleoside reverse transcriptase inhibitor (NRTI) 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) in preclinical development exhibits improved safety and antiviral activity profiles with minimal drug resistance compared to approved NRTIs. However, t
Externí odkaz:
https://doaj.org/article/0ca2a009bc544ee2903bcad5b97978cd