Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Martina, Kocan"'
Autor:
Adam L. Valkovic, Martina Kocan, Brad Hoare, Sarah Marshall, Daniel J. Scott, Ross A. D. Bathgate
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1908 (2022)
Cyclic guanosine monophosphate (cGMP) is a second messenger involved in the regulation of numerous physiological processes. The modulation of cGMP is important in many diseases, but reliably assaying cGMP in live cells in a plate-based format with te
Externí odkaz:
https://doaj.org/article/356bc873d82e40f284dd37f10a5331b6
Autor:
Martina Kocan, Mohsin Sarwar, Sheng Y. Ang, Jingbo Xiao, Juan J. Marugan, Mohammed A. Hossain, Chao Wang, Dana S. Hutchinson, Chrishan S. Samuel, Alexander I. Agoulnik, Ross A. D. Bathgate, Roger J. Summers
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Activation of the relaxin receptor RXFP1 has been associated with improved survival in acute heart failure. ML290 is a small molecule RXFP1 agonist with simple structure, long half-life and high stability. Here we demonstrate that ML290 is a
Externí odkaz:
https://doaj.org/article/dd60bf90c42d4a01bd40b123afd44a23
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202408 (2018)
Toll like receptors (TLRs) are important pattern recognition receptors that can detect pathogen and danger associated molecular patterns to initiate an innate immune response. TLR1 and 2 heterodimerize at the plasma membrane upon binding to triacylat
Externí odkaz:
https://doaj.org/article/a0e0618a92624bf9b0b0550edefe4b44
Autor:
John B. Furness, Praveen Praveen, Mohammed Akhter Hossain, Shuai Nie, Qinghao Ou, Ruslan V Pustovit, Jamie Jm Liew, Xiaozhou Zhang, Martina Kocan, Lalita Oparija-Rogenmozere, Mengjie Liu, Ada Koo, Ross A. D. Bathgate
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Insulin-like peptide 5 (INSL5), the natural ligand for the relaxin family peptide receptor 4 (RXFP4), is a gut hormone that is exclusively produced by colonic L-cells. We have recently developed an analogue of INSL5, INSL5-A13, that
Autor:
Michael D. W. Griffin, Avanka Gunatilaka, Alice R. Whitehead, Ross A. D. Bathgate, Tasneem M. Vaid, Daniel Scott, Paul R. Gooley, Feng-Jie Wu, Lisa M. Williams, Alaa Abdul-Ridha, Martina Kocan
Publikováno v:
Journal of Biological Chemistry. 295:7404-7417
G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an allosteric network encompassing the ligand-binding site and the G protein-binding site. Crystal structures of GPCRs prov
Autor:
Alice R. Whitehead, Fabian Bumbak, Fei Yan, Billy J. Noonan-Williams, Martina Kocan, Shoni Bruell, Tasneem M. Vaid, Daniel Scott, Trayder Thomas, Ross A. D. Bathgate, David K. Chalmers, Margaret A. Johnson, Xuan Tan, Paul R. Gooley
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Cell–cell communication via endogenous peptides and their receptors is vital for controlling all aspects of human physiology and most peptides signal through G protein-coupled receptors (GPCRs). Disordered peptides bind GPCRs thro
Autor:
Michelle L. Halls, Anna L. Sandström, Dana S. Hutchinson, Masaaki Sato, Nodi Dehvari, Jon Merlin, Robert I. Csikasz, Roger J. Summers, Anette I. Öberg, Saori Mukaida, Jessica M. Olsen, Tore Bengtsson, Bronwyn A Evans, Martina Kocan
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 316:R666-R677
The type 2 diabetes epidemic makes it important to find insulin-independent ways to improve glucose homeostasis. This study examines the mechanisms activated by a dual β2-/β3-adrenoceptor agonist, BRL37344, to increase glucose uptake in skeletal mu
Publikováno v:
Molecular and Cellular Endocrinology. 487:24-33
The peptide hormone relaxin mediates many biological actions including anti-fibrotic, vasodilatory, angiogenic, anti-inflammatory, anti-apoptotic, and organ protective effects across a range of tissues. At the cellular level, relaxin binds to the G p
Autor:
Sarah K, Walsh, Christopher, Lipina, Sheng Y, Ang, Masaaki, Sato, Ling Yeong, Chia, Martina, Kocan, Dana S, Hutchinson, Roger J, Summers, Cherry L, Wainwright
Publikováno v:
Biochemical pharmacology. 188
Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not
Autor:
Feng-Jie, Wu, Lisa M, Williams, Alaa, Abdul-Ridha, Avanka, Gunatilaka, Tasneem M, Vaid, Martina, Kocan, Alice R, Whitehead, Michael D W, Griffin, Ross A D, Bathgate, Daniel J, Scott, Paul R, Gooley
Publikováno v:
J Biol Chem
G protein–coupled receptors (GPCRs) use a series of conserved microswitches to transmit signals across the cell membrane via an allosteric network encompassing the ligand-binding site and the G protein-binding site. Crystal structures of GPCRs prov