Complement protein C3a enhances adaptive immune responses towards FVIII products

Autor: Eva Ringler, Samira Ortega Iannazzo, Jessica Herzig, Lisa M. Weiss, Martina Anzaghe, Lilija Miller, Zoe Waibler

Publikováno v: Haematologica, Vol 108, Iss 6 (2023)

The most serious complication in the treatment of hemophilia A (HA) is the development of factor (F)VIII inhibitors or antidrug antibodies (ADA) occurring in 25-35% of patients with severe HA. The immunological mechanisms underlying the development o

Externí odkaz: https://doaj.org/article/efed70b16353476c81b40cf301c28a75

Organ-Specific Expression of IL-1 Receptor Results in Severe Liver Injury in Type I Interferon Receptor Deficient Mice

Autor: Martina Anzaghe, Theresa Resch, Elea Schaser, Stefanie Kronhart, Clara Diez, Marc A. Niles, Eugenia Korotkova, Stefan Schülke, Sonja Wolfheimer, Dorothea Kreuz, Marion Wingerter, María Matilde Bartolomé Rodríguez, Zoe Waibler

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Upon treatment with polyinosinic:polycytidylic acid [poly(I:C)], an artificial double-stranded RNA, type I interferon receptor-deficient (IFNAR−/−) mice develop severe liver injury seen by enhanced alanine aminotransferase (ALT) activity in the s

Externí odkaz: https://doaj.org/article/b643c4839cd14e8abf38257589ce4676

Vaccine-associated enhanced respiratory pathology in COVID-19 hamsters after T(H)2-biased immunization

Autor: Aileen Ebenig, Samada Muraleedharan, Julia Kazmierski, Daniel Todt, Arne Auste, Martina Anzaghe, André Gömer, Dylan Postmus, Patricia Gogesch, Marc Niles, Roland Plesker, Csaba Miskey, Michelle Gellhorn Serra, Angele Breithaupt, Cindy Hörner, Carina Kruip, Rosina Ehmann, Zoltan Ivics, Zoe Waibler, Stephanie Pfaender, Emanuel Wyler, Markus Landthaler, Alexandra Kupke, Geraldine Nouailles, Christine Goffinet, Richard J.P. Brown, Michael D. Mühlebach

Vaccine-associated enhanced respiratory disease (VAERD) is a severe complication for some respiratory infections. To investigate the potential for VAERD induction in coronavirus disease 2019 (COVID-19), we evaluate two vaccine leads utilizing a sever

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27466db8ae8b4532e40612e5d44b512d
http://edoc.mdc-berlin.de/22013/7/22013suppl.zip

In contrast to TH2-biased approaches, TH1 COVID-19 vaccines protect Syrian hamsters from severe disease in the absence of dexamethasone-treatable vaccine-associated enhanced respiratory pathology

Autor: Aileen Ebenig, Samada Muraleedharan, Julia Kazmierski, Daniel Todt, Arne Auste, Martina Anzaghe, André Gömer, Dylan Postmus, Patricia Gogesch, Marc Niles, Roland Plesker, Csaba Miskey, Michelle Gellhorn Serra, Angele Breithaupt, Cindy Hörner, Carina Kruip, Rosina Ehmann, Zoltan Ivics, Zoe Waibler, Stephanie Pfaender, Emanuel Wyler, Markus Landthaler, Alexandra Kupke, Geraldine Nouailles, Christine Goffinet, Richard J.P. Brown, Michael D. Mühlebach

Since December 2019, the novel human coronavirus SARS-CoV-2 has spread globally, causing millions of deaths. Unprecedented efforts have enabled development and authorization of a range of vaccines, which reduce transmission rates and confer protectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ee66773573f04284c10a648f85bc97
https://doi.org/10.1101/2021.12.28.474359

The Role of Fc Receptors on the Effectiveness of Therapeutic Monoclonal Antibodies

Autor: Martina Anzaghe, Simone Dudek, Zoe Waibler, Ger van Zandbergen, Patricia Gogesch

Publikováno v: International Journal of Molecular Sciences
International journal of molecular sciences, 22(16):8947
International Journal of Molecular Sciences, Vol 22, Iss 8947, p 8947 (2021)

Since the approval of the first monoclonal antibody (mAb) in 1986, a huge effort has been made to guarantee safety and efficacy of therapeutic mAbs. As of July 2021, 118 mAbs are approved for the European market for a broad range of clinical indicati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14831255635ba5f90ce94b3ca25a7c1
https://pubmed.ncbi.nlm.nih.gov/34445651