Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Martin de Kort"'
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Akademický článek
Drug repurposing for rare: progress and opportunities for the rare disease community
Autor: Anneliene Hechtelt Jonker, Daniel O’Connor, Maria Cavaller-Bellaubi, Christine Fetro, Maria Gogou, Peter A. C. ’T Hoen, Martin de Kort, Heather Stone, Nivedita Valentine, Anna Maria Gerdina Pasmooij
Publikováno v: Frontiers in Medicine, Vol 11 (2024)
Repurposing is one of the key opportunities to address the unmet rare diseases therapeutic need. Based on cases of drug repurposing in small population conditions, and previous work in drug repurposing, we analyzed the most important lessons learned,
Externí odkaz: https://doaj.org/article/cc6f95ef5fa542e780aabb40d1b8199f
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Half-life prolongation of therapeutic proteins by conjugation to ATIII-binding pentasaccharides: a first-in-human study of CarboCarrier®insulin
Autor: André M. M. Miltenburg, Marita Prohn, Renger G. Tiessen, Jacqueline H. M. van Kuijk, Martin de Kort, Rob J. W. Berg
Publikováno v: British Journal of Clinical Pharmacology. 75:1221-1230
Aim Conjugation to antithrombin III ATIII-binding pentasaccharides has been proposed as a novel method to extend the half-life of therapeutic proteins. We aim to validate this technological concept in man by performing a first-in-human study using Ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::703d7d259ebd386b1f009a31a8f4a9c6
https://doi.org/10.1111/j.1365-2125.2012.04460.x
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From heparin to EP217609: The long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile
Autor: Jeffry A. J. Wisse, Maurice Petitou, Vanessa Nancy-Portebois, D.G. Meuleman, Martin de Kort, Constant A. A. van Boeckel, Gerard M. T. Vogel, Vincent Motte, Guy Dubreucq
Publikováno v: Thrombosis and Haemostasis, 102(5), 804-810. Schattauer GmbH
SummaryThe elucidation of the structure of the antithrombin binding sequence in heparin has given a large impulse to the rational design of heparin related drugs. De novo chemical synthesis of the corresponding pentasaccharide as well as simplified a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e6e79ccd1d36af2e25f70c56617a07
https://doi.org/10.1160/th09-01-0063
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Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes
Autor: Wim H. A. Dokter, Jeffry A. J. Wisse, E Bos, R. Charlotte Moffett, Nigel Irwin, Martin de Kort, Steven Patterson, André M. M. Miltenburg, Peter R. Flatt
Publikováno v: ChemMedChem. 10(8)
The present study details the development of a family of novel D-Ala(8) glucagon-like peptide-1 (GLP-1) peptide conjugates by site specific conjugation to an antithrombin III (ATIII) binding carrier pentasaccharide through tetraethylene glycol linker
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de810e205685d76c366c58c4c1b22d7a
https://pubmed.ncbi.nlm.nih.gov/26059252
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Synthetic heparin derivatives as new anticoagulant drugs
Autor: Rogier C. Buijsman, Constant A. A. van Boeckel, Martin de Kort
Publikováno v: Drug Discovery Today. 10:769-779
The journey towards a detailed mechanistic understanding of the anticoagulant action of heparin has resulted in synthetic mimetics with improved pharmacodynamic profiles. Inspired by the ternary complex formation of heparin with antithrombin III and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d908a41fe672750c57122ef2d90f1792
https://doi.org/10.1016/s1359-6446(05)03457-4
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A Versatile Approach Towards Regioselective Platinated DNA Sequences
Autor: Martin de Kort, Jan Reedijk, Gijs A. van der Marel, Robert Jochem Heetebrij, Nico J. Meeuwenoord, Hans den Dulk, Jacques H. van Boom
Publikováno v: Chemistry - A European Journal. 9:1823-1827
Undesired N(7) platination of 2'-deoxyguanosine residues at predetermined sites in an oligodeoxynucleotide (ODN) sequence is prevented by applying the sterically demanding diphenylcarbamoyl (DPC) as an O(6)-protecting group. The presence of a base-la
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e542ac4cee97f3e0c33a76d5279a3ca9
https://doi.org/10.1002/chem.200390209
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Chemical and Enzymatic Synthesis of DNA Fragments Containing 5-(β-D-Glucopyranosyloxymethyl)-2′-deoxycytidine − a Modified Nucleoside in T4 Phage DNA
Autor: Jürgen Kurzeck, Nico J. Meeuwenoord, Wolfgang Rüger, Gijs A. van der Marel, Martin de Kort, Jacques H. van Boom, Peter C de Visser
Publikováno v: European Journal of Organic Chemistry. 2001:2075-2082
DNA fragments 23 and 25, containing 5-hydroxymethyl-2′-deoxycytidine (5-HMdC) and 5-(β-D-glucopyranosyloxymethyl)-2′-deoxycytidine (5-GlcMdC) units, respectively, were assembled by means of a solid support-assisted synthesis using phosphoramidit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7132a07269dae9c7954871d25a99509c
https://doi.org/10.1002/1099-0690(200106)2001:11<2075::aid-ejoc2075>3.0.co
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