Systematic transcriptional analysis of human cell lines for gene expression landscape and tumor representation

Autor: Han Jin, Cheng Zhang, Martin Zwahlen, Kalle von Feilitzen, Max Karlsson, Mengnan Shi, Meng Yuan, Xiya Song, Xiangyu Li, Hong Yang, Hasan Turkez, Linn Fagerberg, Mathias Uhlén, Adil Mardinoglu

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Abstract Cell lines are valuable resources as model for human biology and translational medicine. It is thus important to explore the concordance between the expression in various cell lines vis-à-vis human native and disease tissues. In this study,

Externí odkaz: https://doaj.org/article/981f4ee29ebc40c8b7248086e28ad99a

Systematic evaluation of SARS‐CoV‐2 antigens enables a highly specific and sensitive multiplex serological COVID‐19 assay

Autor: Sophia Hober, Cecilia Hellström, Jennie Olofsson, Eni Andersson, Sofia Bergström, August Jernbom Falk, Shaghayegh Bayati, Sara Mravinacova, Ronald Sjöberg, Jamil Yousef, Lovisa Skoglund, Sara Kanje, Anna Berling, Anne‐Sophie Svensson, Gabriella Jensen, Henric Enstedt, Delaram Afshari, Lan Lan Xu, Martin Zwahlen, Kalle vonFeilitzen, Leo Hanke, Ben Murrell, Gerald McInerney, Gunilla B Karlsson Hedestam, Christofer Lendel, Robert G Roth, Ingmar Skoog, Elisabet Svenungsson, Tomas Olsson, Anna Fogdell‐Hahn, Ylva Lindroth, Maria Lundgren, Kimia T Maleki, Nina Lagerqvist, Jonas Klingström, Rui Da Silva Rodrigues, Sandra Muschiol, Gordana Bogdanovic, Laila Sara Arroyo Mühr, Carina Eklund, Camilla Lagheden, Joakim Dillner, Åsa Sivertsson, Sebastian Havervall, Charlotte Thålin, Hanna Tegel, Elisa Pin, Anna Månberg, My Hedhammar, Peter Nilsson

Publikováno v: Clinical & Translational Immunology, Vol 10, Iss 7, Pp n/a-n/a (2021)

Abstract Objective The COVID‐19 pandemic poses an immense need for accurate, sensitive and high‐throughput clinical tests, and serological assays are needed for both overarching epidemiological studies and evaluating vaccines. Here, we present th

Externí odkaz: https://doaj.org/article/8b5b60f5e8974c2ab35d2703899e52f2

Genome-wide single cell annotation of the human protein-coding genes

Autor: Max Karlsson, María Bueno Álvez, Mengnan Shi, Loren Méar, Rutger Schutten, Feria Hikmet, Andreas Digre, Borbala Katona, Jimmy Vuu, Martina Bosic, Evelina Sjöstedt, Fredrik Edfors, Per Oksvold, Kalle von Feilitzen, Martin Zwahlen, Mattias Forsberg, Fredric Johansson, Jan Mulder, Tomas Hökfelt, Younglun Luo, Lynn Butler, Wen Zhong, Adil Mardinoglu, Åsa Sivertsson, Fredrik Ponten, Cheng Zhang, Cecilia Lindskog, Linn Fagerberg, Mathias Uhlén

An important quest for the life science community is to deliver a complete annotation of the human building-blocks of life, the genes and the proteins. Here, we report on a genome-wide effort to annotate all protein-coding genes based on single cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9627174ba76090d83e8754d59f61dfa7
https://doi.org/10.1101/2022.08.03.502627

High throughput generation of a resource of the human secretome in mammalian cells

Autor: Mathias Uhlén, Malin Westin, Andreas Hober, LanLan Xu, Björn Forsström, Bjørn G. Voldborg, Faranak Bidad, Siri Ekblad, Delaram Afshari, Lovisa Holmberg Schiavone, Hanna Tegel, Kalle von Feilitzen, Johan Rockberg, Jenny Ottosson Takanen, Fredrik Edfors, Sophia Hober, Anne-Sophie Svensson, Melanie Dannemeyer, Henric Enstedt, Magnus Lundqvist, Sinead Knight, Sven Göpel, Martin Zwahlen, Mona Moradi, Anna Berling, Rick Davies, Anna-Luisa Volk, Åsa Sivertsson, Lorenz M. Mayr, Sara Kanje

Publikováno v: Tegel, H, Dannemeyer, M, Kanje, S, Sivertsson, Å, Berling, A, Svensson, A S, Hober, A, Enstedt, H, Volk, A L, Lundqvist, M, Moradi, M, Afshari, D, Ekblad, S, Xu, L L, Westin, M, Bidad, F, Schiavone, L H, Davies, R, Mayr, L M, Knight, S, Göpel, S O, Voldborg, B G, Edfors, F, Forsström, B, von Feilitzen, K, Zwahlen, M, Rockberg, J, Takanen, J O, Uhlén, M & Hober, S 2020, ' High throughput generation of a resource of the human secretome in mammalian cells ', New Biotechnology, vol. 58, pp. 45-54 . https://doi.org/10.1016/j.nbt.2020.05.002

The proteins secreted by human tissues and blood cells, the secretome, are important both for the basic understanding of human biology and for identification of potential targets for future diagnosis and therapy. Here, a high-throughput mammalian cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3c343bc5f3f5e43bfd18155a712f5c
https://pubmed.ncbi.nlm.nih.gov/32502629

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Autor: Linn Fagerberg, Christian Pou, Adil Mardinoglu, Åsa Sivertsson, Björn Forsström, Per Oksvold, Tadepally Lakshmikanth, Kalle von Feilitzen, Fredrik Pontén, Fredrik Edfors, Jan Mulder, Andreas Hober, Evelina Sjöstedt, Wen Zhong, Mathias Uhlén, Jaromír Mikeš, Petter Brodin, Cecilia Lindskog, Max J. Karlsson, Jacob Odeberg, Abdellah Tebani, Cheng Zhang, Martin Zwahlen

Publikováno v: Science (New York, N.Y.). 366(6472)

INTRODUCTION Blood is the predominant source for molecular analyses in humans, both in clinical and research settings, and is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9136a5310afc38b0da07b317f3a8499b
https://pubmed.ncbi.nlm.nih.gov/31857451