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pro vyhledávání: '"Martin Zatz"'
Autor:
Martin Zatz
Publikováno v:
Journal of Neurochemistry. 62:2001-2011
Light has at least two distinguishable effects on the circadian rhythm of melatonin output displayed by dispersed chick pineal cells in static culture: acute suppression of melatonin output and entrainment (phase shifts) of the underlying pacemaker.
Publikováno v:
The Journal of Neuroscience. 23:10021-10031
Chick pineal cells in culture display a circadian rhythm of melatonin release. Light pulses can entrain (phase shift) the rhythm. One candidate for the photoentrainment pathway uses a mitogen-activated protein kinase (MAPK), also known as extracellul
Autor:
Martin Zatz
Publikováno v:
Seminars in Cell & Developmental Biology. 7:811-820
Chick pineal cells make melatonin rhythmically, even in culture. Light pulses have two effects on these cells: acute suppression of melatonin synthesis and phase shifts (entrainment) of the underlying pacemaker. The two effects use different mechanis
Publikováno v:
Brain Research. 738:1-7
Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin s
Publikováno v:
Brain Research. 669:100-106
The pineal gland synthesizes its hormone melatonin ( O -methyl- N -acetylserotonin) from serotonin. Acetyl-CoA; serotonin N -acetyltransferase (SNAT), the enzyme that catalyzes the committed step in this biosynthesis, is largely restricted to the pin
Autor:
Martin Zatz, Michael S. Wolfe
Publikováno v:
Brain Research. 662:273-277
Chick pineal cells in static culture display a persistent, photosensitive, circadian rhythm of melatonin synthesis and release. Melatonin synthesis and its rhythm are also sensitive to temperature changes. By SDS-PAGE autoradiography, we found that s
Autor:
Martin Zatz
Publikováno v:
Journal of Biological Rhythms. 7:301-311
Cyclic AMP is a key regulator of melatonin production in the chick pineal gland. Agents that raise cyclic AMP levels (such as forskolin), or cyclic AMP analogues (such as 8-bromocyclic AMP), increase melatonin synthesis and release, whereas agents th
Agents that affect calcium influx can change cyclic nucleotide levels in cultured chick pineal cells
Autor:
Martin Zatz
Publikováno v:
Brain Research. 583:304-307
Previous experiments examined interactions among the effects of cyclic AMP and calcium-related agents on melatonin output by cultured chick pineal cells, and suggested that changes in calcium influx might act through cyclic AMP. Here, effects of calc
Publikováno v:
Journal of Neurochemistry. 55:1149-1153
Vasoactive intestinal peptide (VIP) is known to mimic the effects of beta-adrenergic receptor stimulation in the rat pineal, including marked potentiation by alpha 1-adrenergic receptor stimulation, and to cause increased melatonin synthesis. In cont
Autor:
Mark D. Rollag, Cuimei Liu, Iuvone Pm, Martin Zatz, A. Natesan, Rashidul Haque, William Pär Hayes, Gianluca Tosini, Horst-Werner Korf, Gui-Sen Jiang, Shyam S. Chaurasia, Ignacio Provencio
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The avian retina and pineal gland contain autonomous circadian oscillators and photo-entrainment pathways, but the photopigment(s) that mediate entrainment have not been definitively identified. Melanopsin (Opn4) is a novel opsin involved in entrainm