Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Martin Wurtele"'
Autor:
Martin Wurtele, Camila Coelho, Gloria Gallo, Claudia Campos, Leon Hardy, Yunierkis Perez Castillo, Masamitsu Moriwaki, Mahendra P. Kapoor, Damião Pergentino de Sousa
Publikováno v:
Journal of Chemistry, Vol 2023 (2023)
The main protease (Mpro) of SARS-CoV-2 is a well-established drug target for rational drug design of COVID-19 inhibitors. To address the serious challenge of COVID-19, we have performed biochemical inhibition screens with recombinantly expressed SARS
Externí odkaz:
https://doaj.org/article/bbfa5795378245e09150430806efb6d7
Autor:
Silas Pinto, Vitor N. Sato, Evandro A. De-Souza, Rafael C. Ferraz, Henrique Camara, Ana Paula F. Pinca, Diego R. Mazzotti, Michael T. Lovci, Guilherme Tonon, Camila M. Lopes-Ramos, Raphael B. Parmigiani, Martin Wurtele, Katlin B. Massirer, Marcelo A. Mori
Publikováno v:
Redox Biology, Vol 18, Iss , Pp 84-92 (2018)
Alterations in microRNA (miRNA) processing have been previously linked to aging. Here we used the small molecule enoxacin to pharmacologically interfere with miRNA biogenesis and study how it affects aging in C. elegans. Enoxacin extended worm lifesp
Externí odkaz:
https://doaj.org/article/e2472728753c41be9c28092b2a0a0932
Autor:
Carlos C Barros, Anderson Haro, Fernanda J V P Russo, Ines Schadock, Sandro S Almeida, Rosane A Ribeiro, Emerielle C Vanzela, Valeria P Lanzoni, Flavio C Barros, Milton R Moraes, Marcelo A Mori, Reury F P Bacurau, Martin Wurtele, Antônio C Boschero, Everardo M Carneiro, Michael Bader, Joao B Pesquero, Ronaldo C Araujo
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40573 (2012)
The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by bindi
Externí odkaz:
https://doaj.org/article/42aae95a1eb64877a7832a52f0d95886
Autor:
Fernando Maiello, Gloria Gallo, Camila Coelho, Fernanda Sucharski, Leon Hardy, Martin Würtele
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232959 (2020)
The elucidation of mechanisms behind the thermostability of proteins is extremely important both from the theoretical and applied perspective. Here we report the crystal structure of methylenetetrahydrofolate dehydrogenase (MTHFD) from Thermus thermo
Externí odkaz:
https://doaj.org/article/3d7d389012ac4e818573da3757de5b52
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240079 (2020)
The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic represents a global challenge. SARS-CoV-2's ability to replicate in host cells relies on the action of its non-structural proteins, like its main protease (Mpro). This cystein
Externí odkaz:
https://doaj.org/article/5c41263dceec4c37836ac4e184c4f332
Autor:
Francisco Navarro, Aline V. N. Bacurau, Andréa Vanzelli, Marcela Meneguello-Coutinho, Marco C. Uchida, Milton R. Moraes, Sandro S. Almeida, Frederick Wasinski, Carlos C. Barros, Martin Würtele, Ronaldo C. Araújo, Luís F. B. Costa Rosa, Reury F. P. Bacurau
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
In lymphocytes (LY), the well-documented antiproliferative effects of IFN-α are associated with inhibition of protein synthesis, decreased amino acid incorporation, and cell cycle arrest. However, the effects of this cytokine on the metabolism of gl
Externí odkaz:
https://doaj.org/article/efebfd50f0a54d3eba0c5ac2b6efba3e