Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Martin Wepler"'
Autor:
Martin Wepler, Jonathan M. Preuss, Cornelia Tilp, Martina Keck, Jochen Blender, Ulrich Wachter, Tamara Merz, Josef Vogt, Sandra Kress, Michael Gröger, Andrea Hoffmann, Marina Fink, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionWe previously showed that attenuated glucocorticoid receptor (GR) function in mice (GRdim/dim) aggravates systemic hypotension and impairs organ function during endotoxic shock. Hemorrhagic shock (HS) causes impaired organ perfusion, whic
Externí odkaz:
https://doaj.org/article/23e5c3a8c9d64ee397a1cb91a3748c37
Publikováno v:
BMC Medical Education, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Medical simulation trainings lead to an improvement in patient care by increasing technical and non-technical skills, procedural confidence and medical knowledge. For structured simulation-based trainings, objective assessment too
Externí odkaz:
https://doaj.org/article/4cc6d53c2418462dbc205b3e72daea10
Autor:
Martin Wepler, Jonathan M. Preuss, Tamara Merz, Oscar McCook, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-13 (2020)
Abstract Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act through the glucocorticoid receptor (
Externí odkaz:
https://doaj.org/article/8b3e96d58f1a4370aea081abf7cf80ec
Autor:
Xiaomin Zhang, Fabian Zink, Felix Hezel, Josef Vogt, Ulrich Wachter, Martin Wepler, Maurizio Loconte, Christine Kranz, Andreas Hellmann, Boris Mizaikoff, Peter Radermacher, Clair Hartmann
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-14 (2020)
Abstract Immune cell activation leads to the acquisition of new functions, such as proliferation, chemotaxis, and cytokine production. These functional changes require continuous metabolic adaption in order to sustain ATP homeostasis for sufficient h
Externí odkaz:
https://doaj.org/article/a31a16de3a14400f9f2e336d85df91cf
Autor:
Tamara Merz, Nicole Denoix, Martin Wepler, Holger Gäßler, David A. C. Messerer, Clair Hartmann, Thomas Datzmann, Peter Radermacher, Oscar McCook
Publikováno v:
Intensive Care Medicine Experimental, Vol 8, Iss S1, Pp 1-16 (2020)
Abstract This review addresses the plausibility of hydrogen sulfide (H2S) therapy for acute lung injury (ALI) and circulatory shock, by contrasting the promising preclinical results to the present clinical reality. The review discusses how the narrow
Externí odkaz:
https://doaj.org/article/16410610cb7548f4b2df983ecf0534c4
Autor:
Tamara Merz, Martin Wepler, Benedikt Nußbaum, Josef Vogt, Enrico Calzia, Rui Wang, Csaba Szabo, Peter Radermacher, Oscar McCook
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Sepsis is associated with disturbed glucose metabolism and reduced mitochondrial activity and biogenesis, ultimately leading to multiple organ dysfunction, e.g., acute kidney injury (AKI). Cystathionine-γ-lyase (CSE), the major c
Externí odkaz:
https://doaj.org/article/8f9598f617584b13a9bd618ddba8beaa
Autor:
Tamara Merz, Britta Lukaschewski, Daniela Wigger, Aileen Rupprecht, Martin Wepler, Michael Gröger, Clair Hartmann, Matthew Whiteman, Csaba Szabo, Rui Wang, Christiane Waller, Peter Radermacher, Oscar McCook
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Background Both the hydrogen sulfide/cystathionine-γ-lyase (H2S/CSE) and oxytocin/oxytocin receptor (OT/OTR) systems have been reported to be cardioprotective. H2S can stimulate OT release, thereby affecting blood volume and pressure regula
Externí odkaz:
https://doaj.org/article/75043ece5c854d7c92ce5cc6f3e917ed
Autor:
Andre Bredthauer, Karla Lehle, Angelika Scheuerle, Hubert Schelzig, Oscar McCook, Peter Radermacher, Csaba Szabo, Martin Wepler, Florian Simon
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Objective In rodents, intravenous sulfide protected against spinal cord ischemia/reperfusion (I/R) injury during aortic balloon occlusion. We investigated the effect of intravenous sulfide on aortic occlusion-induced porcine spinal cord I/R
Externí odkaz:
https://doaj.org/article/b5008412a9114809a4eb502b1fce41be
Autor:
Tamara Merz, Nicole Denoix, Daniela Wigger, Christiane Waller, Martin Wepler, Sabine Vettorazzi, Jan Tuckermann, Peter Radermacher, Oscar McCook
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous H
Externí odkaz:
https://doaj.org/article/6017d7853f4c4ac49944f2c20c0b43bb
Autor:
Martin Wepler, Jonathan M. Preuss, Tamara Merz, Clair Hartmann, Ulrich Wachter, Oscar McCook, Josef Vogt, Sandra Kress, Michael Gröger, Marina Fink, Angelika Scheuerle, Peter Möller, Enrico Calzia, Ute Burret, Peter Radermacher, Jan P. Tuckermann, Sabine Vettorazzi
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Background: Sepsis, that can be modeled by LPS injections, as an acute systemic inflammation syndrome is the most common cause for acute lung injury (ALI). ALI induces acute respiratory failure leading to hypoxemia, which is often associated with mul
Externí odkaz:
https://doaj.org/article/e7eb751a8d3c4d92a79ccbbb51d3408e