Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Martin Weichert"'
Publikováno v:
Current Research in Microbial Sciences, Vol 3, Iss , Pp 100119- (2022)
One of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus, an environmental mold that causes a life-threatening pneumonia with a high rate of morbidity and mortality. Despite advances in therapy, issues of drug toxicity
Externí odkaz:
https://doaj.org/article/153fec2477c84a678df67f2e83f970ca
Autor:
José P. Guirao-Abad, Martin Weichert, Ginés Luengo-Gil, Sarah Sze Wah Wong, Vishukumar Aimanianda, Christina Grisham, Nikita Malev, Shivani Reddy, Laura Woollett, David S. Askew
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
The fungal UPR is an adaptive signaling pathway in the ER that buffers fluctuations in ER stress but also serves as a virulence regulatory hub in species of pathogenic fungi that rely on secretory pathway homeostasis for pathogenicity. This study dem
Externí odkaz:
https://doaj.org/article/fa945191fa4942a0a1c0c0808abce8b6
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The unfolded protein response (UPR) is a signaling network that maintains homeostasis of the endoplasmic reticulum (ER). In the human-pathogenic fungus Aspergillus fumigatus, the UPR is initiated by activation of an endoribonuclease (RNase)
Externí odkaz:
https://doaj.org/article/de64c7c49fec4315af7cd50de0ba93da
Autor:
Martin Weichert, José Guirao-Abad, Vishukumar Aimanianda, Karthik Krishnan, Christina Grisham, Patrick Snyder, Alex Sheehan, Ruthvik R. Abbu, Hong Liu, Scott G. Filler, Eric I. Gruenstein, Jean-Paul Latgé, David S. Askew
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Many species of pathogenic fungi deploy the unfolded protein response (UPR) to expand the folding capacity of the endoplasmic reticulum (ER) in proportion to the demand for virulence-related proteins that traffic through the secretory pathwa
Externí odkaz:
https://doaj.org/article/007980a41c5748d0a0a5bb8f3bb9a8fa
Autor:
Sarah-Anne Robson, Stefan Schulz, Bert-Ewald Priegnitz, Stephanie Herzog, Ulrike Brandt, André Fleißner, Raphael Brandt, Martin Weichert
Publikováno v:
Genetics
Cell-to-cell fusion is crucial for the development and propagation of most eukaryotic organisms. Despite this importance, the molecular mechanisms mediating this process are only poorly understood in biological systems. In particular, the step of pla
Autor:
Hamzeh Haj Hammadeh, Antonio Serrano, Valentin Wernet, Natascha Stomberg, Davina Hellmeier, Martin Weichert, Ulrike Brandt, Bianca Sieg, Konstantin Kanofsky, Reinhard Hehl, Reinhard Fischer, André Fleißner
Publikováno v:
Proceedings of the National Academy of Sciences. 119
In many filamentous fungi, germinating spores cooperate by fusing into supracellular structures, which develop into the mycelial colony. In the model fungus Neurospora crassa, this social behavior is mediated by an intriguing mode of communication, i
Publikováno v:
Current research in microbial sciences. 3
One of the most potent opportunistic fungal pathogens of humans is
Autor:
Ginés Luengo-Gil, Shivani Reddy, David S. Askew, Laura A. Woollett, Vishukumar Aimanianda, Sarah Sze Wah Wong, José P. Guirao-Abad, Nikita Malev, Christina Grisham, Martin Weichert
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio, 2021, 12 (5), pp.e0273521. ⟨10.1128/mBio.02735-21⟩
mBio
mBio, 2021, 12 (5), pp.e0273521. ⟨10.1128/mBio.02735-21⟩
International audience; Aspergillus fumigatus is a human-pathogenic mold that extracts nutrients from the environment or from host tissues by secreting hydrolytic enzymes. The ability of A. fumigatus to adjust secretion levels in proportion to demand
Autor:
Christina Grisham, José P. Guirao-Abad, David S. Askew, Alex Sheehan, Ruthvik R. Abbu, Scott G. Filler, Martin Weichert, Patrick Snyder, Karthik Krishnan, Hong Liu, Jean-Paul Latgé, Vishukumar Aimanianda, Eric Gruenstein
Publikováno v:
mBio, Vol 11, Iss 3, p e01060-20 (2020)
mBio
mBio, 2020, 11 (3), ⟨10.1128/mBio.01060-20⟩
mBio, American Society for Microbiology, 2020, 11 (3), ⟨10.1128/mBio.01060-20⟩
mBio, vol 11, iss 3
mBio, Vol 11, Iss 3 (2020)
mBio
mBio, 2020, 11 (3), ⟨10.1128/mBio.01060-20⟩
mBio, American Society for Microbiology, 2020, 11 (3), ⟨10.1128/mBio.01060-20⟩
mBio, vol 11, iss 3
mBio, Vol 11, Iss 3 (2020)
The UPR is an intracellular signal transduction pathway that maintains homeostasis of the ER. The pathway is also tightly linked to the expression of virulence-related traits in diverse species of human-pathogenic and plant-pathogenic fungal species,
Autor:
Katharina Herbst, Matthias Bujara, Ann Kathrin Heroven, Wiebke Opitz, Martin Weichert, Ariane Zimmermann, Petra Dersch
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000435 (2009)
Pathogens, which alternate between environmental reservoirs and a mammalian host, frequently use thermal sensing devices to adjust virulence gene expression. Here, we identify the Yersinia virulence regulator RovA as a protein thermometer. Thermal sh
Externí odkaz:
https://doaj.org/article/9ef9afdc65474192a04baa3142d3b8f8