Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Martin Wahlestedt"'
Autor:
Karolina Komorowska, Alexander Doyle, Martin Wahlestedt, Agatheeswaran Subramaniam, Shubhranshu Debnath, Jun Chen, Shamit Soneji, Ben Van Handel, Hanna K.A. Mikkola, Kenichi Miharada, David Bryder, Jonas Larsson, Mattias Magnusson
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3514-3523 (2017)
Summary: The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and
Externí odkaz:
https://doaj.org/article/93653e5e1b494a609acf2a52b536dffe
Autor:
Martin Wahlestedt, Vasileios Ladopoulos, Isabel Hidalgo, Manuel Sanchez Castillo, Rebecca Hannah, Petter Säwén, Haixia Wan, Monika Dudenhöffer-Pfeifer, Mattias Magnusson, Gudmundur L. Norddahl, Berthold Göttgens, David Bryder
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2251-2263 (2017)
A gradual restriction in lineage potential of multipotent stem/progenitor cells is a hallmark of adult hematopoiesis, but the underlying molecular events governing these processes remain incompletely understood. Here, we identified robust expression
Externí odkaz:
https://doaj.org/article/e70749f7161d481aa24a512bdbb87977
Autor:
Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L. Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Age-associated decline in tissue function has been linked to alterations in adult stem cells, with implications for organ homeostasis and cellular therapy. Here, the authors study the heterogeneity of ageing mouse haematopoietic stem cells (HSCs) and
Externí odkaz:
https://doaj.org/article/45468cb969c947199083e10e2b6af32d
Autor:
Amol Ugale, Gudmundur L. Norddahl, Martin Wahlestedt, Petter Säwén, Pekka Jaako, Cornelis Jan Pronk, Shamit Soneji, Jörg Cammenga, David Bryder
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1246-1255 (2014)
Studies of developmental pathways of hematopoietic stem cells (HSCs) have defined lineage relationships throughout the blood system. This is relevant to acute myeloid leukemia (AML), where aggressiveness and therapeutic responsiveness can be influenc
Externí odkaz:
https://doaj.org/article/c4741b7b55ce4fbab0fbd79d05e03d44
Autor:
Isabel Hidalgo, Martin Wahlestedt, Ouyang Yuan, Qinyu Zhang, David Bryder, Cornelis Jan Pronk
Publikováno v:
Experimental Hematology. 109:35-44
The Polycomb complex protein Bmi1 is regarded as a master regulator of hematopoietic stem cells (HSCs). In the blood system, HSCs express Bmi1 most abundantly, and Bmi1 expression wanes as cells differentiate. Furthermore, Bmi1 has been found to be o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ad99b82f867e2d26214bdf164d9358
https://doi.org/10.1016/j.exphem.2022.02.004
https://doi.org/10.1016/j.exphem.2022.02.004
Autor:
Shubhranshu Debnath, Agatheeswaran Subramaniam, Hanna K. A. Mikkola, David Bryder, Kenichi Miharada, Mattias Magnusson, Karolina Komorowska, Jonas Larsson, Jun Chen, Martin Wahlestedt, Ben Van Handel, Alexander Doyle, Shamit Soneji
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3514-3523 (2017)
Summary: The transcription factor hepatic leukemia factor (HLF) is strongly expressed in hematopoietic stem cells (HSCs) and is thought to influence both HSC self-renewal and leukemogenesis. However, the physiological role of HLF in hematopoiesis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362b63da17e392e84ddc1fc6d748042c
http://www.sciencedirect.com/science/article/pii/S2211124717317515
http://www.sciencedirect.com/science/article/pii/S2211124717317515
Autor:
Martin Wahlestedt, David Bryder
Publikováno v:
Experimental Hematology. 56:1-6
The late stages of life, in most species including humans, are associated with a decline in the overall maintenance and health of the organism. This applies also to the hematopoietic system, where aging is not only associated with an increased predis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54b8ed57738a9c714b42ae1e4ca9659
https://doi.org/10.1016/j.exphem.2017.09.008
https://doi.org/10.1016/j.exphem.2017.09.008
Autor:
David Bryder, Manuel Sánchez Castillo, Martin Wahlestedt, Petter Säwén, Vasileios Ladopoulos, Rebecca Hannah, Isabel Hidalgo, Berthold Göttgens, Monika Dudenhöffer-Pfeifer, Haixia Wan, Gudmundur L. Norddahl, Mattias Magnusson
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2251-2263 (2017)
Cell Reports
Cell Reports
Summary A gradual restriction in lineage potential of multipotent stem/progenitor cells is a hallmark of adult hematopoiesis, but the underlying molecular events governing these processes remain incompletely understood. Here, we identified robust exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a370e19e3b12bac76a4daa7b37844535
https://doi.org/10.1016/j.celrep.2017.10.112
https://doi.org/10.1016/j.celrep.2017.10.112
Autor:
David Bryder, Gudmundur L. Norddahl, Martin Wahlestedt, Amol Ugale, Petter Säwén, Monika Dudenhöffer-Pfeifer
Publikováno v:
Oncogene. 36:3207-3212
Translocations involving the mixed lineage leukemia-1 are recurrent events in acute leukemia and associate with lymphoid (ALL), myeloid (AML) or mixed lineage (MLL) subtypes. Despite an association with ALL in humans, murine MLL fusion models are per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926c7a34ea92e0eabf80e689f2169d32
https://doi.org/10.1038/onc.2016.470
https://doi.org/10.1038/onc.2016.470
Publikováno v:
Stem Cells Translational Medicine. 4:186-194
Because of the continuous increases in lifetime expectancy, the incidence of age-related diseases will, unless counteracted, represent an increasing problem at both the individual and socioeconomic levels. Studies on the processes of blood cell forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0125c1e7536cb27080c8b5a192a801b6
https://doi.org/10.5966/sctm.2014-0132
https://doi.org/10.5966/sctm.2014-0132