Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Martin W. LaFleur"'
1
Akademický článek
A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system
Autor: Martin W. LaFleur, Thao H. Nguyen, Matthew A. Coxe, Kathleen B. Yates, Justin D. Trombley, Sarah A. Weiss, Flavian D. Brown, Jacob E. Gillis, Daniel J. Coxe, John G. Doench, W. Nicholas Haining, Arlene H. Sharpe
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The use of functional genomics in primary immune cells has been limited by inefficient vector delivery and risk of perturbing cell states. Here the authors present CHimeric IMmune Editing (CHIME) for in vivo evaluation of gene function and pooled scr
Externí odkaz: https://doaj.org/article/f4cc26f0a06e487587662b0cfb8d4512
Zobrazit plný text záznamu
2
Akademický článek
T Cell Activation Depends on Extracellular Alanine
Autor: Noga Ron-Harel, Jonathan M. Ghergurovich, Giulia Notarangelo, Martin W. LaFleur, Yoshiki Tsubosaka, Arlene H. Sharpe, Joshua D. Rabinowitz, Marcia C. Haigis
Publikováno v: Cell Reports, Vol 28, Iss 12, Pp 3011-3021.e4 (2019)
Summary: T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. The expression of transporters for these nutrients is
Externí odkaz: https://doaj.org/article/53d10ea0f66f47f5a51cee88780c0c77
Zobrazit plný text záznamu
8
Data from Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Autor: Arlene H. Sharpe, Marcia C. Haigis, Justin D. Trombley, Vikram R. Juneja, Kiran Kurmi, Cong-Hui Yao, Alison E. Ringel, Martin W. LaFleur, Isaac S. Harris, Emily F. Gaudiano, Thao H. Nguyen, Tara Muijlwijk, Jacob E. Gillis, Jefte M. Drijvers
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting of metabolism in either popula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c0136f14266cee38042c4d6aaa2846
https://doi.org/10.1158/2326-6066.c.6550425.v1
Zobrazit plný text záznamu
9
CRISPR Screens to Identify Regulators of Tumor Immunity
Autor: Martin W. LaFleur, Arlene H. Sharpe
Publikováno v: Annu Rev Cancer Biol
Cancer immunotherapies, such as immune checkpoint blockade (ICB), have been used in a wide range of tumor types with immense clinical benefit. However, ICB does not work in all patients, and attempts to combine ICB with other immune-based therapies h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6388d6672c4622a7e644ec6d7879860f
https://pubmed.ncbi.nlm.nih.gov/35989706
Zobrazit plný text záznamu
10
Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells
Autor: Vikram R. Juneja, Arlene H. Sharpe, Isaac S. Harris, Jacob E. Gillis, Emily F. Gaudiano, Marcia C. Haigis, Thao H. Nguyen, Alison E. Ringel, Tara Muijlwijk, Jefte M. Drijvers, Martin W. LaFleur, Cong-Hui Yao, Kiran Kurmi, Justin D. Trombley
Publikováno v: Cancer Immunology Research. 9:184-199
Metabolic constraints in the tumor microenvironment constitute a barrier to effective antitumor immunity and similarities in the metabolic properties of T cells and cancer cells impede the specific therapeutic targeting of metabolism in either popula
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::551cf95d46e57f86ad2f5da3330eece6
https://doi.org/10.1158/2326-6066.cir-20-0384
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje